Background And Objectives: Stress and anxiety are the current global problem facing by mothers of differently abled children and that leading to lower quality of life. Presence of a special child in a family is known to impact families in varied ways. A good parent and child relationships are vital for the development of children. Therefore, this study was undertaken to find the effectiveness of Jacobson progressive relaxation, acceptance & commitment therapy and cognitive behavioral therapy on stress in mothers of differently abled children. Methodology: Twenty subjects were selected based on inclusion and exclusion criteria, then divided into two groups. Experimental group (n= 10) received Jacobson progressive relaxation, acceptance & commitment therapy and cognitive behavioral therapy. Control group (n=10) not received any intervention. Exercise program was held for three days a week for 40 minutes for 8 weeks. Stress, anxiety and quality of life were measured at the pre and post of intervention using Parenting stress scale, State – Trait Anxiety Inventory and World Health Organization Quality Of Life- Bref. Results & Discussion: Paired t test is used to analyze the results within the group and independent t test were used to analyze the results between the groups. The significance level kept as p < 0.05. From pre to post eight week intervention, statistically significant changes were observed in all of the outcome measures. Conclusion: A combined intervention of Jacobson progressive relaxation, acceptance & commitment therapy and cognitive behavioral therapy are effective in improving stress, anxiety and quality of life in mothers of differently abled children. Keywords: Mother’s stress, anxiety and quality of life; Jacobson progressive relaxation, Acceptance & commitment therapy and Cognitive behavioral therapy.