The emerging global environmental crisis, intensified by global warming, necessitates a deeper understanding of climate variations, especially in critical geographical divisions like the Qinling-Huaihe demarcation zone, which acts as a natural division between northern and southern mainland China. This study investigates the spatial–temporal differentiation of climatic elements within the Qinling-Huaihe demarcation zone from 1961 to 2018, employing data accumulated from 144 meteorological stations. Utilizing methodologies including the univariate linear regression, the Mann-Kendall test, and the Kriging interpolation, this investigation unveils the spatial–temporal variation characteristics of precipitation, relative humidity, and temperature. Temporally, the climatic alterations in the zone are predominantly marked by warming trends, significantly pronounced since the 1990s, with the elevation in minimum temperature being the most notable. Both precipitation and relative humidity exhibit a fluctuating ascending trend. Spatial analysis reveals a west-to-east increase in precipitation, while relative humidity presents lower values in the central region, escalating towards the eastern and western edges. The spatial distribution patterns for average, maximum, and minimum temperatures align closely, showcasing higher temperatures in the central region, extending to the Huaihe River area, with the Qinling Mountains exhibiting the lowest temperatures, particularly noticeable north of the Qinling Mountains.