Socio-economic transformation in many post-communist states has influenced the dynamic process in such states with the differentiation trends. Such process often causes disparities in different regions, creates relations and ties, often contradictory, and spatial socio-economic polarization in the regions. The above-mentioned processes and their impacts are demonstrated on the example of the South Bohemian region, in particular the LAG territory. Using the methods of correlation analysis, the author demonstrates the conditionality of the indicators in the area of interest. Different links and relations of socio-economic, infrastructural and natural factors to the emergence of disparities in different LAGs are analyzed. The most important factors of the emerging disparities within the region and the LAGs include the relations between the progressiveness of the economic structure and population density and between the demographic structure of the region and the infrastructure, as revealed by the analysis.