As the impacts of climate change on urban environments and buildings become more and more prominent, building comfort and structural safety monitoring becomes crucial. However, efficiently storing and managing the multi-source monitoring data generated during the long-term monitoring process has been an urgent challenge. In order to solve the above problems, this paper designs and develops a spatial database management system for building comfort and structural safety monitoring based on standard database development tools. A conceptual model of a spatial database for building comfort and structural safety monitoring is proposed, and the entities, attributes, and connections in the model are discussed to transform the E-R conceptual model into a logical model supported by an object-relational spatial database management system. Based on this conceptual and logical model, a mainstream backend framework was adopted and combined with common database and programming language tools and BIM (Building Information Modeling) technology for development to establish a spatial database management system with data storage, management, analysis, and visualization functions. We designed building monitoring experiments and proved through the experiments that the database management system can stably store, analyze, and manage the monitoring data and visualize the display, with the advantages of a fast response speed and low error rate. The spatial database system improves the storage and management efficiency of building comfort and structural safety monitoring data, eliminates redundant data, and realizes comprehensive analysis and management of building comfort and structural safety monitoring data. It provides data support for building comfort and structural safety assessment, helps users analyze the formation mechanism and evolution law of the urban heat island effect, assesses the interrelationship between climate change and urban building morphology, and constructs an urban thermal environment that is more adaptable to climate change.