The article presents the results of research activities for 2023 of the Federal State Budget Scientific Institution All-Russian National Research Institute of Viticulture and Winemaking Magarach of the RAS in the field of winemaking, carried out in accordance with the Program of Fundamental Scientific Research in the Russian Federation for the long term (2021-2030). The methodology of wine quality management with ecostatus has been created, aimed at revealing the individual characteristics of wines caused by natural factors and reducing the risks of negative effects on humans. Promising yeast strains have been identified: Steinberg, Champanskaya G-14, ShM-30, Novocimlyanskaya 3 with a description of their taxonomic affiliation, morphological and physiological-biochemical properties. Two strains of O. oeni active acid-reducing agents are recommended for practical use. The application of technology for the production of young sparkling wines of Crimean autochthonous grape The article presents the results of research activities for 2023 of the Federal State Budget Scientific Institution All-Russian National Research Institute of Viticulture and Winemaking Magarach of the RAS in the field of winemaking, carried out in accordance with the Program of Fundamental Scientific Research in the Russian Federation for the long term (2021-2030). The methodology of wine quality management with ecostatus has been created, aimed at revealing the individual characteristics of wines caused by natural factors and reducing the risks of negative effects on humans. Promising yeast strains have been identified: Steinberg, Champanskaya G-14, ShM-30, Novocimlyanskaya 3 with a description of their taxonomic affiliation, morphological and physiological-biochemical properties. Two strains of O. oeni active acid-reducing agents are recommended for practical use. The application of technology for the production of young sparkling wines of Crimean autochthonous grape varieties: Kokur belyi, Sary Pandas, Soldaiya and Kefesiya is justified. The system of criteria indicators for assessing the quality of grapes for the production of high-quality cognac distillates and cognacs is substantiated. A working collection of 63 natural strains of lactic acid bacteria has been formed. The optimal technological factors of the process of single-stage extraction by infusing with a food water-alcohol solution of green grape shoots of the Vitis vinifera, Vitis abrusca species have been established, allowing to increase the yield of total polyphenols by at least 2.6 times for the production of functional products. The most optimal technological modes of cold treatment of dry and fortified wine materials have been established to substantiate the constructive solution of an energy-saving installation for the purpose of cold treatment of wine materials based on the study of the main factors affecting the mass transfer process of potassium bitartrate crystallization. The obtained results of research work contribute to improving the quality of domestic wine products and expanding its production, including winemaking with ecological and geographical statuses, the production of domestic cognac and grape processing products of a functional orientation. The introduction of scientific developments into production will increase the competitiveness of domestic wine products, accelerate import substitution and ensure the country's food independence.