Space Travel Research Articles

How the adaptation of the human microbiome to harsh space environment can determine the chances of success for a space mission to Mars and beyond.

The ability of human cells to adapt to space radiation is essential for the well-being of astronauts during long-distance space expeditions, such as voyages to Mars or other deep space destinations. However, the adaptation of the microbiomes should not be overlooked. Microorganisms inside an astronaut's body, or inside the space station or other spacecraft, will also be exposed to radiation, which may induce resistance to antibiotics, UV, heat, desiccation, and other life-threatening factors. Therefore, it is essential to consider the potential effects of radiation not only on humans but also on their microbiomes to develop effective risk reduction strategies for space missions. Studying the human microbiome in space missions can have several potential benefits, including but not limited to a better understanding of the major effects space travel has on human health, developing new technologies for monitoring health and developing new radiation therapies and treatments. While radioadaptive response in astronauts' cells can lead to resistance against high levels of space radiation, radioadaptive response in their microbiome can lead to resistance against UV, heat, desiccation, antibiotics, and radiation. As astronauts and their microbiomes compete to adapt to the space environment. The microorganisms may emerge as the winners, leading to life-threatening situations due to lethal infections. Therefore, understanding the magnitude of the adaptation of microorganisms before launching a space mission is crucial to be able to develop effective strategies to mitigate the risks associated with radiation exposure. Ensuring the safety and well-being of astronauts during long-duration space missions and minimizing the risks linked with radiation exposure can be achieved by adopting this approach.

Influence of microgravity on spontaneous calcium activity of primary hippocampal neurons grown in microfluidic chips

The influence of variations of gravity, either hypergravity or microgravity, on the brain of astronauts is a major concern for long journeys in space, to the Moon or to Mars, or simply long-duration missions on the ISS (International Space Station). Monitoring brain activity, before and after ISS missions already demonstrated important and long term effects on the brains of astronauts. In this study, we focus on the influence of gravity variations at the cellular level on primary hippocampal neurons. A dedicated setup has been designed and built to perform live calcium imaging during parabolic flights. During a CNES (Centre National d’Etudes Spatiales) parabolic flight campaign, we were able to observe and monitor the calcium activity of 2D networks of neurons inside microfluidic devices during gravity changes over different parabolas. Our preliminary results clearly indicate a modification of the calcium activity associated to variations of gravity.

Hazards During Spaceflight Can Affect Human Health

Space missions present several unique challenges to human health and performance, including space radiation, unique gravity fields, living with just a small group of companions in a small space for a long time, limited resources like food and water, and being far away from Earth. Since our last visit to the Moon, scientists at the National Aeronautics and Space Administration (NASA) have identified over 20 categories of human health risks that are related to these spaceflight hazards. Identifying the human health risks posed by space travel allows new science experiments to be designed and new knowledge to be gained, so we can ensure the health and safety of astronauts on their journeys of space exploration. In this article, we will set off on our own exploration mission to discover and learn about some of the main hazards and related health risks that space travelers will encounter.

Application of Private International Law in Space Travel at a Distance of Light Years Using Future Technologies

In particular, the article hints at the possibility of conflicts between states due to competition for resources in space, as well as the lack of full regulation of legal aspects in interstellar space. Particular attention is paid to the development of international treaties and mechanisms aimed at resolving these issues and ensuring peace and cooperation in outer space. Such documents can become the basis for creating a single legal space in outer space, where the rights and obligations of all entities will be clearly defined. The article concludes by emphasizing that the development of future space technologies requires a global approach to legal regulation to ensure security and stability in space, as well as the use of these new opportunities for the common benefit of all mankind. The article examines the topical issue of application of private international law to space travel over distances of light years using advanced technologies of the future. Travelling in space over such a vast distance is becoming increasingly realistic due to the development of astronomical research and technological progress. Legal aspects are an important aspect of such travel, as space activities raise numerous legal issues. Private international law defines the legal status of persons and objects in space representing different states. The application of this law requires resolving issues of jurisdiction, ownership, liability, and conflict resolution between different states and space actors. Future technologies, such as high-speed interstellar transportation and expanded habitat modules in space stations, introduce new challenges to the regulation of these issues. The article raises a lot of questions to which answers will still be found, and this process is a process that belongs to the future. At this stage, it is not known who else in the world would raise similar issues in the context of private international law, public international law, and international law in general.

Cardiovascular Effects of Cosmic Radiation and Microgravity.

Recent spaceflights involving nonprofessional people have opened the doors to the suborbital space tourism business. However, they have also drawn public attention to the safety and hazards associated with space travel. Unfortunately, space travel involves a myriad of health risks for people, ranging from DNA damage caused by radiation exposure to the hemodynamic changes that occur when living in microgravity. In fact, the primary pathogenetic role is attributed to cosmic radiation, since deep space lacks the protective benefit of Earth's magnetic shielding. The second risk factor for space-induced pathologies is microgravity, which may affect organ function and cause a different distribution of fluid inside the human body. Both cosmic radiation and microgravity may lead to the alteration of cellular homeostasis and molecular changes in cell function. These, in turn, might have a direct impact on heart function and structure. The aim of this review is to draw attention to the fact that spaceflights constitute a novel frontier in biomedical research. We summarize the most important clinical and experimental evidence regarding the cardiovascular effects of cosmic radiation and microgravity. Finally, we highlight that unraveling the mechanisms underlying how space radiation and microgravity affect the cardiovascular system is crucial for identifying potential countermeasures and developing effective therapeutic strategies.

Cardiovascular Challenges Beyond Earth: Investigating the Impact of Space Travel on Astronauts' Cardiovascular Health.

In the coming decades, as humanity aims to establish a presence on Mars, there is a growing significance in comprehending, monitoring, and controlling the diverse health challenges arising from space exploration. The extended exposure to microgravity during space missions leads to various physical alterations in astronauts, such as shifts in bodily fluids, reduced plasma volume, loss of bone density, muscle wasting, and cardiovascular deconditioning. These changes can ultimately lead to orthostatic intolerance, underscoring the increasing importance of addressing these health risks. Astronauts are exposed to cosmic radiation consisting of high-energy particles from various sources, including solar cosmic rays and galactic cosmic rays. These radiations can impact the electrical signals in the heart, potentially causing irregular heart rhythms. Understanding the risks to the heart and blood circulation brought on by exposure to space radiation and the overall stress of spaceflight is essential and this article reviews the cardiovascular effects of space travel on astronauts.

Chromosomal positioning and epigenetic architecture influence DNA methylation patterns triggered by galactic cosmic radiation

Despite surging interest in space travel in recent decades, the impacts of prolonged, elevated exposure to galactic cosmic radiation (GCR) on human health remain poorly understood. This form of ionizing radiation causes significant changes to biological systems including damage to DNA structure by altering epigenetic phenotype with emphasis on DNA methylation. Building on previous work by Kennedy et al. (Sci Rep 8(1): 6709. 10.1038/S41598-018-24755-8), we evaluated spatial DNA methylation patterns triggered by high-LET (56Fe, 28Si) and low-LET (X-ray) radiation and the influence of chromosome positioning and epigenetic architecture in distinct radial layers of cell nucleus. Next, we validated our results using gene expression data of mice irradiated with simulated GCR and JAXA astronauts. We showed that primarily 56Fe induces a persistent DNA methylation increase whereas 28Si and X-ray induce a decrease DNA methylation which is not persistent with time. Moreover, we highlighted the role of nuclear chromatin architecture in cell response to external radiation. In summary, our study provides novel insights towards epigenetic and transcriptomic response as well as chromatin multidimensional structure influence on galactic cosmic radiation damage.

Monitoring functional immune responses with a cytokine release assay: ISS flight hardware design and experimental protocol for whole blood cultures executed under microgravity conditions.

Introduction: Long-term space missions trigger a prolonged neuroendocrine stress response leading to immune system dysregulation evidenced by susceptibility to infections, viral reactivation, and skin irritations. However, due to existing technical constraints, real-time functional immune assessments are not currently available to crew inflight. The in vitro cytokine release assay (CRA) has been effectively employed to study the stimulated cytokine response of immune cells in whole blood albeit limited to pre- and post-flight sessions. A novel two-valve reaction tube (RT) has been developed to enable the execution of the CRA on the International Space Station (ISS). Methods: In a comprehensive test campaign, we assessed the suitability of three materials (silicone, C-Flex, and PVC) for the RT design in terms of biochemical compatibility, chemical stability, and final data quality analysis. Furthermore, we thoroughly examined additional quality criteria such as safety, handling, and the frozen storage of antigens within the RTs. The validation of the proposed crew procedure was conducted during a parabolic flight campaign. Results: The selected material and procedure proved to be both feasible and secure yielding consistent and dependable data outcomes. This new hardware allows for the stimulation of blood samples on board the ISS, with subsequent analysis still conducted on the ground. Discussion: The resultant data promises to offer a more accurate understanding of the stress-induced neuroendocrine modulation of immunity during space travel providing valuable insights for the scientific community. Furthermore, the versatile nature of the RT suggests its potential utility as a testing platform for various other assays or sample types.

Exploring the complexities of drug formulation selection, storage, and shelf-life for exploration spaceflight.

Medications have been a part of space travel dating back to the Apollo missions. Currently, medical kits aboard the International Space Station (ISS) contain medications and supplies to treat a variety of possible medical events. As we prepare for more distant exploration missions to Mars and beyond, risk management planning for astronaut healthcare should include the assembly of a medication formulary that is comprehensive enough to prevent or treat anticipated medical events, remains safe and chemically stable, and retains sufficient potency to last for the duration of the mission. Emerging innovation and technologies in pharmaceutical development, delivery, quality maintenance, and validation offer promise for addressing these challenges. The present editorial will summarize the current state of knowledge regarding innovative formulary optimization strategies, pharmaceutical stability assessment techniques, and storage and packaging solutions that could enhance drug safety and efficacy for future exploration spaceflight missions.

A Review of Numerical Models of Radiation Injury and Repair Considering Subcellular Targets and the Extracellular Microenvironment.

Astronauts in space are subject to continuous exposure to ionizing radiation. There is concern about the acute and late-occurring adverse health effects that astronauts could incur following a protracted exposure to the space radiation environment. Therefore, it is vital to consider the current tools and models used to describe and study the organic consequences of ionizing radiation exposure. It is equally important to see where these models could be improved. Historically, radiobiological models focused on how radiation damages nuclear deoxyribonucleic acid (DNA) and the role DNA repair mechanisms play in resulting biological effects, building on the hypotheses of Crowther and Lea from the 1940s and 1960s, and they neglected other subcellular targets outside of nuclear DNA. The development of these models and the current state of knowledge about radiation effects impacting astronauts in orbit, as well as how the radiation environment and cellular microenvironment are incorporated into these radiobiological models, aid our understanding of the influence space travel may have on astronaut health. It is vital to consider the current tools and models used to describe the organic consequences of ionizing radiation exposure and identify where they can be further improved.

Sustainable Space Travel: What Can We Do in Education from Economic and Environmental Perspectives?

Space travel began in 2001 and became popular in 2021 because of commercial operations. With the development of space technology and commercialization, like re-launchable rockets used to travel to space in recent years, hawse have gradually entered the space era. However, the space industry causes massive emissions, inducing some opposition to its development. It is essential to investigate the attitude of residents toward space travel and balance the pros and cons of sustainability. A quantitative analysis was adopted to test two models based on duality theory. The data were obtained from 284 samples from various regions of China and analyzed using partial least squares structural equation modeling (PLS-SEM). The results show that the two-factor model of economic development conflicted with environmental protection. However, study two indicates that educational interventions can facilitate sustainable space travel because they mediate the relationship between economic and environmental factors.

Det planetariske blik

With the breakthrough of the space industry after World War II, it became possible for the first time to view the Earth from space, resulting in two of the most spectacular images in history, “Earthrise” (1968) and “The Blue Marble” (1972). Building on these images and the new sensitivity to the Earth that emerged as a result of space technologies and satellite-based observations of the planet during the Cold War, the article argues that German writer Günter Kunert (1929-2019) was one of the few who understood from the very beginning the importance and significance of this “Copernican revolution of the gaze”, and that in his poetry from the early 1960s onwards, he continuously explored man’s place in the cosmos in the age of space travel.

Whole transcriptome analysis highlights nutrient limitation of nitrogen cycle bacteria in simulated microgravity

Regenerative life support systems (RLSS) will play a vital role in achieving self-sufficiency during long-distance space travel. Urine conversion into a liquid nitrate-based fertilizer is a key process in most RLSS. This study describes the effects of simulated microgravity (SMG) on Comamonas testosteroni, Nitrosomonas europaea, Nitrobacter winogradskyi and a tripartite culture of the three, in the context of nitrogen recovery for the Micro-Ecological Life Support System Alternative (MELiSSA). Rotary cell culture systems (RCCS) and random positioning machines (RPM) were used as SMG analogues. The transcriptional responses of the cultures were elucidated. For CO2-producing C. testosteroni and the tripartite culture, a PermaLifeTM PL-70 cell culture bag mounted on an in-house 3D-printed holder was applied to eliminate air bubble formation during SMG cultivation. Gene expression changes indicated that the fluid dynamics in SMG caused nutrient and O2 limitation. Genes involved in urea hydrolysis and nitrification were minimally affected, while denitrification-related gene expression was increased. The findings highlight potential challenges for nitrogen recovery in space.

Characterization of the mechanical properties of the mouse Achilles tendon enthesis by microindentation. Effects of unloading and subsequent reloading

The fibrocartilaginous tendon enthesis, i.e. the site where a tendon is attached to bone through a fibrocartilaginous tissue, is considered as a functionally graded interface. However, at local scale, a very limited number of studies have characterized micromechanical properties of this transitional tissue. The first goal of this work was to characterize the micromechanical properties of the mineralized part of the healthy Achilles tendon enthesis (ATE) through microindentation testing and to assess the degree of mineralization and of carbonation of mineral crystals by Raman spectroscopy. Since little is known about enthesis biological plasticity, our second objective was to examine the effects of unloading and reloading, using a mouse hindlimb-unloading model, on both the micromechanical properties and the mineral phase of the ATE. Elastic modulus, hardness, degree of mineralization, and degree of carbonation were assessed after 14 days of hindlimb suspension and again after a subsequent 6 days of reloading. The elastic modulus gradually increased along the mineralized part of the ATE from the tidemark to the subchondral bone, with the same trend being found for hardness. Whereas the degree of carbonation did not differ according to zone of measurement, the degree of mineralization increased by >70 % from tidemark to subchondral bone. Thus, the gradient in micromechanical properties is in part explained by a mineralization gradient. A 14-day unloading period did not appear to affect the gradient of micromechanical properties of the ATE, nor the degree of mineralization or carbonation. However, contrary to a short period of unloading, early return to normal mechanical load reduced the micromechanical properties gradient, regardless of carbonate-to-phosphate ratios, likely due to the more homogeneous degree of mineralization. These findings provide valuable data not only for tissue bioengineering, but also for musculoskeletal clinical studies and microgravity studies focusing on long-term space travel by astronauts.

More May Not be Better: Enhanced Spacecraft Shielding May Exacerbate Cognitive Decrements by Increasing Pion Exposures during Deep Space Exploration.

The pervasiveness of deep space radiation remains a confounding factor for the transit of humans through our solar system. Spacecraft shielding both protects astronauts but also contributes to absorbed dose through galactic cosmic ray interactions that produce secondary particles. The resultant biological effects drop to a minimum for aluminum shielding around 20 g/cm2 but increase with additional shielding. The present work evaluates for the first time, the impact of secondary pions on central nervous system functionality. The fractional pion dose emanating from thicker shielded spacecraft regions could contribute up to 10% of the total absorbed radiation dose. New results from the Paul Scherrer Institute have revealed that low dose exposures to 150 MeV positive and negative pions, akin to a Mars mission, result in significant, long-lasting cognitive impairments. These surprising findings emphasize the need to carefully evaluate shielding configurations to optimize safe exposure limits for astronauts during deep space travel.

Towards Sustainable Ceramic Forming: Techniques, Materials, and Applications in Evolving Paradigms

In the sustainability of ceramic forming this paper will provide a comprehensive review of the way that ceramics have changed over time towards sustainability due to Industry 4.0’s current manufacturing technologies which are improving day by day. Particularly this study focuses on reducing the depletion of resources, energy utilization, and natural pollution by examining how conventional strategies for forming ceramics can be replaced by new ones that emphasize sustainability and form a solution. Basically, this paper highlights a few crucial properties in ceramics including its capacity to resist high temperatures, flexibility, and chemical inactivity, and their significance in several areas like biomedical designing, hardware, aviation, the machinery industry, and many more applications. When the drawbacks of traditional ceramic forming methods were analyzed such as high cost and lengthy processing periods, the study clarifies that there is a need for sustainable alternatives. This study also examines new possibilities such as additive manufacturing (3D printing) and hydroforming, which permit for more accuracy in product shape while utilizing a low amount of materials and energy. Going forward, this research also looks into eco-friendly ceramic materials that make the most of secondary sources or are based on biomass-based added substances and binders. Using examples from real circumstances and information from industry, it demonstrates where sustainable ceramics can be utilized in different divisions like design, space travel, electronics, wellbeing care, or renewable energy sources. By doing so, this paper emphasizes how sustainable ceramic making seems to trigger environmental enhancements as well as keep up resource efficiency and shift towards a circular economy.

Establishing Neural Organoid Cultures for Investigating the Effects of Microgravity in Low-Earth Orbit (LEO).

Recent findings from studies involving astronauts and animal models indicate that microgravity increases immune cell activity and potentially alters the white and gray matter of the central nervous system (CNS). To further investigate the impact of microgravity on CNS cells, we established cultures of three-dimensional neural organoids containing isogenic microglia, the brain's resident immune cells, and sent them onboard the International Space Station. When using induced pluripotent stem cell (iPSC) lines from individuals affected by neuroinflammatory and neurodegenerative diseases such as multiple sclerosis (MS) and Parkinson's disease (PD), these cultures can provide novel insights into pathogenic pathways that may be exacerbated by microgravity. We have devised a cryovial culture strategy that enables organoids to be maintained through space travel and onboard the International Space Station (ISS) without the need for medium or carbon dioxide exchange. Here, we provide a comprehensive description of all the steps involved: generating various types of neural organoids, establishing long-term cultures, arranging plans for shipment to the Kennedy Space Center (KSC), and ultimately preparing organoids for launch into low-Earth orbit (LEO) and return to Earth for post-flight analyses.

Addressing Space Tourism’s Environmental Effects: Marine Environment Regulations as a Basis for Regulating Orbital Space Debris

With the success of private suborbital space flight, the space industry is now facing unprecedented growth as billionaires strive to accomplish the task of sending astrotourists into space. However, given the novelty of this objective, the current domestic and international legal regimes governing outer space and space travel are both confusing and outdated, and thus, they have not adequately accounted for space tourism activities. Given the projected growth of this industry, detrimental and dangerous environmental effects—such as an increase in orbital space debris—have become a pressing concern. These effects will not only affect the global climate on Earth but will likely pose additional obstacles to future space travel by cluttering the Earth’s stratosphere. Therefore, this comment proposes a new international regulatory framework based on the London Protocol and the United Nations Convention on the Law of the Sea—two instances of international cooperation protecting the marine environment—in order to regulate the environmental effects stemming from space tourism activities.

Voltage, power, and energy production of a Shewanella oneidensis biofilm microbial fuel cell in microgravity

Future long-term space travel requires both efficient waste management and renewable energy production to be feasible. One such option in addressing these issues is a microbial fuel cell (MFC) that converts chemical energy in organic matter to electrical energy through biological processes of microbes. Electroactive biofilms are special colonies of microbes that utilize an extracellular matrix to increase the endurance and growth of bacterial colonies through the sharing of resources and the depositing of electrons. We studied the power production of a biofilm MFC by testing the fuel cell in microgravity over time on the International Space Station (ISS). We utilized Shewanella oneidensis, an established electroactive biofilm, to break down a nutrient solution and release electrons and protons, producing a voltage difference across the cell. The S. onedensis biofilm grew more prolifically under low-pressure conditions, making it well suited for microgravity; consequently, the consumption of sodium lactate in a larger biofilm caused an increase in anaerobic respiration of the bacteria. This increased the voltage difference recorded across the cell and the corresponding power of the MFC. Our results are consistent with our hypothesis that there would be an increase in voltage and power production over time; however, an insufficient amount of growth medium eventually led to a decrease in voltage and power production as the biofilm died out. Power output during microgravity testing increased over time, coinciding with nutrient solution pump cycles. This experiment established that an MFC is a promising avenue for the development of renewable energy in microgravity.

Science Fiction's Facial Optics

abstract: In science fiction films involving space travel, the face is often linked aesthetically and conceptually not only with the flat surface of the screen interface but also the spherical environments of the helmet, the spacecraft, and the planetary atmosphere. I explore the relations between eye, face, and screen in Stanley Kubrick's 2001 and its successors, showing how they use facial-optical motifs to mediate encounters between human subjectivity and unfathomable otherness. Ultimately, investigating the ethical dimensions of space exploration cinema's aesthetics of roundness, I argue that recent films display a turning inward and a contraction of both ethical and ontological spheres.