Internal combustion engines are widely used in vehicles, ships, construction machinery, and agricultural machinery due to their reliability, durability, and high efficiency. Furthermore, they will be the main powertrains for above powerplant in the next 50 years according to the wide studies. However, the development of engines is faced with some serious challenges in the future, such as the stringent emission regulations, petroleum energy supply, and greenhouse gas emissions. Therefore, we need to develop some advanced combustion technologies to reduce the pollutant emissions. Meanwhile, to prevent global warming, we need to improve the thermal efficiencies of engines and thereby reduce CO 2 emissions and save petroleum oil. Fuel properties have remarkable effects on engine performance and emissions. High-efficiency and low-emission engines must need the cooperation of high-quality fuels. Meantime, the future advanced engines may need the improved fuel properties which are different from the current gasoline or diesel fuel. In addition, the alternative biofuels have recently gained significant political and scientific interests owing to the concerns about climate change, global energy security, and petroleum supply shortage in the foreseeable future. In this special issue, firstly, N. Li et al. from State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation, Southwest Petroleum University, present the improvement on production of petroleum oil. Secondly, C. Jin and Z.Q. Zheng from Tianjin University and B. Yang et al. from Shandong University of Technology present the need for engine fuel properties for future advanced combustionmodes such as homogeneous charge compression ignition and low temperature combustion. Finally, L. Dong et al. from Civil Aviation University of China and F. Zhang et al. from Hunan University present how to achieve high-efficiency and clean combustion based on cooperated control of fuel, oil, and engines. Finally, we hope this special issue can give you some help to understand the tight relationship between petroleum and engines and to know the future engine combustion technologies and the needs for future engine fuels and oil.