Himalayan orogenesis remains enigmatic in terms of Tibetan Plateau geodynamics originating from the Cenozoic India–Eurasian continental collision. India underthrusts below Tibet to the Yarlung–Tsangpo suture, which has been identified as the northernmost boundary for underplating. However, the way in which the historical evolution of continental subduction induces plateau uplift and the way it controls the variation in uplift between outboard and inboard areas is still unclear. To interpret the evolutionary mechanisms involved in the Himalayan growth history, we constructed different 3-D dynamic models at important stages to address these questions related to the formation of the Himalayas on the basis of paleoenthalpy evidence encoded in fossil leaves from recently documented assemblages in southern Tibet. The results show that (1) the effect of crustal thickening was the predominant factor in the early evolution from the Paleocene to the early Eocene, which resulted in a moderate growth rate. (2) The consecutive slab break-off eastward from the western syntaxis and the associated slab rebound significantly accelerated orogenesis from the late Eocene to the Oligocene. The upwelling asthenospheric flow was a key control of increasing crustal buoyancy, which resulted in the fastest growth of the Himalayas during the early Miocene. (3) Thereafter, the gradually enhanced monsoon and surface erosion during accompanying the increasing mountain height resulted in a slowdown of the orogenic rate, which counterbalanced the buoyant force produced by asthenospheric flow driving continuous Himalayan growth.