<i>Climate change is statistical variations over an extended period in the features of the climate system, such as variations in global temperatures and precipitation, caused by human and natural sources.</i> In this study aimed to measure and examine how streamflow in the Dawa sub-basin, Genale Dawa River basin was affected by climate change. It used the average of five regional climate models from the Coordinated Regional Climate Downscaling Experiment (CORDEX) Africa, under two different scenarios of Representative Concentration Pathways: RCP4.5 and RCP8.5. The baseline scenario was based on the data from 1975 to 2005, while the future scenarios were based on the data from 2020s (2025–2054) and 2050s (2055–2084). The HBV hydrological model used to assess the impact on streamflow. The HBV model showed good statistical performance in simulating the impact of climate change on streamflow, with a coefficient of determination (R<sup>2</sup>) of 0.88 and Nash-Sutcliffe Efficiency (NSE) of 0.77 for monthly calibration, and R<sup>2</sup> of 0.86 and NSE of 0.83 for monthly validation. The impacts quantified using the mean monthly changes in precipitation, maximum and minimum temperatures. The bias-corrected precipitation and temperature showed a reasonable increase in both future periods for both RCP 4.5 and RCP 8.5 scenarios. These changes in climate variables resulted in a decrease in mean annual streamflow by 1.6 and 3.5% for RCP 4.5 and by 4.6 and 4.9% for RCP 8.5 scenarios of the 2020s and 2050s, respectively. Based on the analysis that predicted a drop in precipitation during the months, and seasons and an increase in precipitation during the <i>Belg</i> season, with a corresponding decrease and rise in stream flow throughout the watershed. So to offset the variation in the watershed, community should adopt various; Soil and water conservation technologies, Using drought tolerant crops, Implementing various trees and appropriate design and applying a water harvesting structure like in-situ, internal or micro catchment, external or macro catchment water harvesting and Surface runoff harvesting. This result offers useful information for current and future water resource management in the basin and similar other watershed in the country.