South Central Asia Research Articles

Additional surface-water deficit to meet global universal water accessibility by 2030

Universal access to safe drinking water for all is a key target of the United Nations Sustainable Development Goal 6. However, how water accessibility improvement impacts domestic water demand and surface-water deficit (the quantity of water demand that exceeds surface-water availability) are poorly known due to uncertainty and variability in domestic water use intensities (WUIdom). Here, we developed a data-driven model to create global gridded maps of historical and future WUIdom, constrained by 1758 survey-based records spanning 220 administrative units. The results show that water accessibility improvement dominated the growth in WUIdom over the period 1990–2015, particularly in developing and least-developed economies. Achieving universal water accessibility by 2030 may lead to an additional growth in global mean WUIdom by 21.7 L capita−1 day−1. Additional 88.3 million people, from 14 developing countries and 9 least-developed countries, may move into domestic surface-water deficit. Another 16% of global irrigated areas would be at risk of irrigation surface-water deficit mainly in South Asia, Central Asia, and North Africa. These findings imply the need of spatially flexible set of actions to achieve global universal water accessibility by 2030 without worsening surface-water deficit.

Awareness of Oral Cancer in a Community of Tarahara, Sunsari, Nepal

Background and Objectives: Oral cancer is one of the highly prevalent cancers worldwide and a leading cause of mortality in certain regions like South-Central Asia and a major public health problem. According to National Health Policy, oral cancer is the most common form of cancer in men and the third most common cancer in females in Nepal. Several studies have shown that public is not well aware of risk factors associated with oral cancer. The objective of this study was to assess the awareness of oral cancer among people of Tarahara-20.
 Material and Methods: A cross-sectional descriptive study was conducted among people of age group 18-65 years in 2019. Data were collected from 128 respondents through face to face interview using Semi – structured interview schedule with non-probability purposive sampling method. Data entry and analysis was done in SPSS version 17. Descriptive statistics i.e. frequency, percentage, mean and standard deviation was used to assess the level of knowledge and inferential statistics i.e. chi square was used to find the association between awareness of oral cancer and selected demographic variables.
 Results: Total findings of the study showed that More than half (52.3%) of respondents were known about treatment modalities of Oral cancer whereas two third, 78.9% of respondents stated out movement is best for physical rehabilitation. Likewise, more than half (65.6%) had moderate level of awareness and 28.1% of the respondents had inadequate level of awareness regarding oral cancer. The result showed there was no association between level of awareness of oral cancer and selected demographic variables.
 Conclusion: The study concluded that awareness regarding oral cancer is moderate among community people of Tarhara. It reflects that efforts should be made to increase the awareness regarding oral cancer. Health education regarding oral cancer and its risk factors with periodic reinforcement will play an important role in creating awareness.

Dispersed pollen and calyx remains of Diospyros (Ebenaceae) from the middle Miocene “Plant beds” of Søby, Denmark

ABSTRACT Diospyros is a large genus of woody flowering plants with a predominantly subtropical and tropical modern distribution. Fossils attributed to Diospyros are mainly leaf impressions from Cretaceous and Cenozoic strata across the Northern Hemisphere. However, it is difficult to assign such fossils to Diospyros because genus-diagnostic leaf characteristics remain to be identified. Unequivocal fossil records of Diospyros are few, including staminate flowers with in situ pollen from the late Eocene of South Australia and dispersed pollen from Cenozoic strata in the Northern Hemisphere. Here, we investigated dispersed pollen and calyx remains from Miocene deposits of Denmark using a combined scanning electron/light microscopy approach. Tricolporate, relatively large pollen with lalongate pori and long bow-shaped colpi and a distinctive micro/nanorugulate exine ornamentation together with persistent 4-lobed flower calyces allow unambiguous identification of the genus. Based on the large size of the calyx, we describe a new fossil-species of Diospyros. Further, a review of the fossil pollen record of Diospyros shows that, in addition to the Australian record, the genus was present in South China, western North America and Europe during the Eocene and in East and South Africa and Central Asia during the Oligo-Miocene. Although still scanty, the pollen record can contribute vital information for time-calibrated molecular phylogenies to resolve conflicting biogeographic inferences. A thorough description of the historical biogeography of Diospyros is still in its infancy. While we initiate such a study here, development of a comprehensive picture will require further studies of dispersed pollen grains with high taxonomic resolution.

Opportunities, Risks and Countermeasures of China`s Investment in Afghanistan

Afghanistan is a strategic hub connecting South Asia, Central Asia and West Asia. The United States, Russia, India and other power countries are extremely concerned with Afghanistan. Although the United States will gradually withdraw, it will retain military bases in Afghanistan. Afghanistan is currently in a critical period of transition from war to peace. To deal with the chaos in Afghanistan in the era of withdrawal, China needs to layout in Afghanistan early. This can not only promote the stability of China’s western region, but also help China and Central and Western Asian countries to promote cooperation under the framework of The Belt and Road Initiatives. The key to layout in Afghanistan is the China-Pakistan Economic Corridor. China-Pakistan Economic Corridor has achieved remarkable results in Pakistan. China Investment and construction experiences in Pakistan will bring better economic benefits to Afghanistan and china.

Moisture sources of heavy precipitation in Xinjiang characterized by meteorological patterns

AbstractIn this study, the FLEXible PARTicle dispersion model (FLEXPART) is applied to determine the moisture source of heavy precipitation in Xinjiang in the wet season (April–September) from 1979 to 2018. This is investigated for different meteorological patterns of heavy precipitation categories based on the self-organizing maps (SOM) method. The SOM results suggest that there are four main meteorological patterns (N1, N2, N3 and N4) for heavy precipitation in Xinjiang. These match the strength and position of geopotential height anomalies at middle-high levels over Central Asia and indicate the anomalous activities of the Central Asia trough and vortex. Further analysis shows that the heavy precipitation is centered at the Tianshan Mountains and the Kunlun Mountains in the N1 and N3 patterns and around the Tianshan Mountains in the N2 and N4 patterns. There are four moisture source regions that contribute to each of the four meteorological patterns for heavy precipitation in Xinjiang, which are listed in descending order of their contribution rates: southern Xinjiang (29–37%), North–Central Asia (19–27%), northern Xinjiang (14–19%), and South–Central Asia (13–16%). The contribution of each source to the heavy precipitation in Xinjiang varies with the meteorological pattern. Additionally, the contribution rates of each source region match well with the precipitation-related particle aggregation before heavy precipitation days. These results help us better understand the moisture source of the heavy precipitation in Xinjiang.

Investigating the Temporal and Spatial Dynamics of Human Development Index: A Comparative Study on Countries and Regions in the Eastern Hemisphere from the Perspective of Evolution

The Human Development Index (HDI) is a prevailing indicator to present the status and trend of sustainability of nations, hereby offers a valuable measurement on the Sustainable Development Goals (SDGs). Revealing the dynamics of the HDI of the Eastern Hemisphere countries is vital for measurement and evaluation of the human development process and revealing the spatial disparities and evolutionary characteristics of human development. However, the statistical data-based HDI, which is currently widely applied, has defects in terms of data availability and inconsistent statistical caliber. To tackle such an existing gap, we applied nighttime lights (NTL) data to reconstruct new HDI indicators named HDINTL and quantify the HDINTL at multispatial scales of Eastern Hemisphere countries during 1992–2013. Results showed that South Central Asia countries had the smallest discrepancies in HDINTL, while the largest was found in North Africa. The national-level HDINTL values in the Eastern Hemisphere ranged between 0.138 and 0.947 during 1992–2013. At the subnational scale, the distribution pattern of HDINTL was spatially clustered based on the results of spatial autocorrelation analysis. The evolutionary trajectory of subnational level HDINTL exhibited a decreasing and then increasing trend along the northwest to the southeast direction of Eastern Hemisphere. At the pixel scale, 93.52% of the grids showed an increasing trend in HDINTL, especially in the urban agglomerations of China and India. These results are essential for the ever-improvement of policy making to reduce HDI’s regional disparity and promote the continuous development of humankind’s living qualities. This study offers an improved HDI accounting method. It expects to extend the channel of HDI application, e.g., potential integration with environmental, physical, and socioeconomic data where the NTL data could present as well.

HOW HAS THE CORONAVIRUS OUTBREAK AFFECTED ECONOMIC POVERTY IN DIFFERENT ASIAN REGIONS?

It is widely believed that the global economy is experiencing unprecedented challenges by the Covid-19. The main purpose of this research is to explore how the Covid-19 outbreak affected poverty in different Asian regions classified by the United Nations geoscheme, namely South Asia, Southeastern Asia, Central Asia, East Asia and Western Asia. To estimate the coefficients of variables, the panel data framework based on quarterly data over 2010Q1–2020Q2 is employed. Results revealed that the Covid-19 pandemic is a serious challenge for poverty in these regions. The impacts of the pandemic on poverty are smaller for larger or developed economies in Asia than smaller or less-developed economies. Regulating and making a timeline for managing post-coronavirus period is a major policy implication. Another policy implication is that due to the similar findings for Asian countries, they can exchange experiences in controlling the pandemic impacts.

Anthropological analyses of 30 insertion/deletion autosomal markers in five major ethnic groups of Pakistan

We investigated the forensic efficacy of the 30 insertion/deletion (Indel) markers included in the Qiagen Investigator® DIPplex kit in 529 Pakistani individuals from five major subpopulations in Pakistan (Punjabi, Pashtun, Sindhi, Saraiki, and Baloch). In the Sindhi population, the distribution of HLD81 and HLD97 alleles deviated from Hardy-Weinberg equilibrium after Bonferroni correction. The combined match probability ranged from 2.0E-12 (Pashtun and Baloch) to 1.0E-12 (Sindhi), and the mean paternity exclusion power varied from 0.995 (Punjabi, Sindhi, and Saraiki) to 0.996 (Pashtun and Baloch). The high combined power of discrimination (0.999 999 999 999 97) and low combined match probability (1.7E-12) for all subpopulations studied support the utility of the 30 Indel markers for forensic identification in the studied subpopulations. The allele frequencies of the Indel markers in the Pakistani subpopulations were compared with those from 18 other populations. The results show that the populations clustered according to geography. The subpopulations investigated in this work showed a close genetic relationship with others from Pakistan, as well as with South Central Asian and Middle Eastern populations. The results suggest that the Investigator® DIPplex kit can be useful as a supplementary tool for human identification in the five Pakistani subpopulations investigated in this study. Supplemental data for this article is available online at https://doi.org/10.1080/20961790.2021.1933366 .

Genetic relationships of Southwest Asian and Mediterranean populations

The Southwest Asian, circum-Mediterranean, and Southern European populations (collectively, SWAMSE) together with Northern European populations form one of five “continental” groups of global populations in many analyses of population relationships. This region is of great anthropologic and forensic interest but relationships of large numbers of populations within the region have not been able to be cleanly resolved with autosomal genetic markers. To examine the genetic boundaries to the SWAMSE region and whether internal structure can be detected we have assembled data for a total of 151 separate autosomal genetic markers on populations in this region and other parts of the world for a global set of 95 populations. The markers include 83 ancestry informative SNPs as singletons and 68 microhaplotype loci defined by 204 SNPs. The 151 loci are ancestry informative on a global scale, identifying at least five biogeographic clusters. One of those clusters is a clear grouping of 37 populations containing the SWAMSE plus northern European populations to the exclusion of populations in South Central Asia and populations from farther East. A refined analysis of the 37 populations shows the northern European populations clustering separately from the SWAMSE populations. Within Southwest Asia the Samaritans and Shabaks are distinct outliers. The Yemenite Jews, Saudi, Kuwaiti, Palestinian Arabs, and Southern Tunisians cluster together loosely while the remaining populations from Northern Iraq, Mediterranean Europe, the Caucasus region, and Iran cluster in a more complex graded fashion. The majority of the SWAMSE populations from the mainland of Southwest Asia form a cluster with little internal structure reflecting a very complex history of endogamy and migrations. The set of 151 DNA polymorphisms not only distinguishes major geographical regions globally but can distinguish ancestry to a small degree within geographical regions such as SWAMSE. We discuss forensic characteristics of the polymorphisms and also identify those that rank highest by Rosenberg’s In measure for the SWAMSE region populations and for the global set of populations analyzed. Data availabilityGenotypes on all 151 markers for all 3790 individuals typed in the Kidd Lab on the 72 Kidd lab populations have been deposited in the Zenodo archive and can be freely accessed at https://doi.org/10.5281/zenodo.4658892. Some of the data has been made public previously as supplemental files appended to publications. Data for the additional individuals included in the analyses was taken from already public datasets as indicated in the text.

Analysis of Skin Pigmentation and Genetic Ancestry in Three Subpopulations from Pakistan: Punjabi, Pashtun, and Baloch.

Skin pigmentation is one of the most prominent and variable phenotypes in humans. We compared the alleles of 163 SNPs and indels from the Human Pigmentation (HuPi) AmpliSeq™ Custom panel, and biogeographic ancestry with the quantitative skin pigmentation levels on the upper arm, lower arm, and forehead of 299 Pakistani individuals from three subpopulations: Baloch, Pashtun, and Punjabi. The biogeographic ancestry of each individual was estimated using the Precision ID Ancestry Panel. All individuals were mainly of mixed South-Central Asian and European ancestry. However, the Baloch individuals also had an average proportion of Sub-Saharan African ancestry of approximately 10%, whereas it was <1% in the Punjabi and Pashtun individuals. The pairwise genetic distances between the Pashtun, Punjabi, and Baloch subpopulations based on the ancestry markers were statistically significantly different. Individuals from the Pashtun subpopulation had statistically significantly lower skin pigmentation than individuals from the Punjabi and Baloch subpopulations (p < 0.05). The proportions of European and Sub-Saharan African ancestry and five SNPs (rs1042602, rs10831496, rs1426654, rs16891982, and rs12913832) were statistically significantly associated with skin pigmentation at either the upper arm, lower arm or forehead in the Pakistani population after correction for multiple testing (p < 10−3). A model based on four of these SNPs (rs1426654, rs1042602, rs16891982, and rs12913832) explained 33% of the upper arm skin pigmentation. The four SNPs and the proportions of European and Sub-Saharan African ancestry explained 37% of the upper arm skin pigmentation. Our results indicate that the four likely causative SNPs, rs1426654, rs1042602, rs16891982, and rs12913832 located in SLC24A5, TYR, SLC45A2, and HERC2, respectively, are essential for skin color variation in the admixed Pakistani subpopulations.

Medical School Accreditation Factors Associated With Certification by the Educational Commission for Foreign Medical Graduates (ECFMG): A 10-Year International Study.

In 2024, international medical graduates seeking Educational Commission for Foreign Medical Graduates (ECFMG) certification will be required to graduate from an accredited medical school. This study's goal was to examine relationships between medical school accreditation variables and ECFMG certification for a global sample. Using ECFMG databases, the authors created a 10-year cohort (January 1, 2007-December 31, 2016) of certification applicants, defined as individuals who had attempted at least 2 examinations required for certification. The authors aggregated applicant data at the school level, excluding schools with < 80 applicants. School accreditation statuses were based on agency websites. School region, age, and time of first accreditation were included. Analyses included descriptive and bivariate statistics and multiple linear regressions adjusting for school start year and year of first accreditation. The cohort included 128,046 applicants from 1,973 medical schools across 162 countries. After excluding low-volume schools, 318 schools across 81 countries remained. These provided 99,598 applicants and 77,919 certificate holders, three-quarters of whom came from the Caribbean, South-Central Asia, and West Asia regions. Two hundred and fifty (78.6%) schools were accredited; 68 (21.4%) were not. Most ECFMG applicants (n = 84,776, 85.1%) and certificate holders (n = 68,444, 87.8%) attended accredited medical schools. Accredited schools had higher rates of ECFMG certification among graduates than nonaccredited schools in comparisons that included all schools (75.0% [standard deviation (SD) = 10.6%] vs 68.3% (SD = 15.9%), P < .001), and for countries that had both accredited and nonaccredited schools (73.9% [SD = 11.4%] vs 67.3% [SD = 16.8%], P = .023). After adjusting for age of school, longer duration of accreditation was associated with higher certification rates (P < .001). Accreditation had a positive association with ECFMG certification rates. Future studies should investigate how accreditation processes might account for higher certification rates.

Legal framework for Azerbaijan – EU cooperation in the energy sector

This article is dedicated to the analysis of legal framework of Azerbaijan &amp;ndash; EU relations in the energy sector. The relevance of this topic in recent months is substantiated by change in geopolitical realities of the South Caucasus Region, and discussions on unblocking economic and transport communications that intensified after the Second Nagorno-Karabakh Conflict. The region is an interlink between Asia and Europe; and Azerbaijan, being an exporter of oil and natural gas, is an important energy partner of the European Union. The flip of political situation in the region in the nearest future would change not only the energy relations between the countries of the region, but also EU and EAEU members-states. The subject of this research is the bilateral agreements, memoranda and joint declarations adopted by the parties in 30 years since reestablishment of the independence of Azerbaijan. Special attention is given to the vectors of cooperation of the parties both pertaining to extraction and transit of energy resources from South Caucasus and Central Asia. The author employs general dialectical, logical, historical, descriptive, formal-legal approach methods of research methods to determine the key trends and characteristics of the legal framework of Azerbaijan &amp;ndash; EU relations in the energy sector. The scientific novelty of lies in the analysis of normative legal framework of cooperation in the energy sector beyond the context of general political and economic relations, as well as in outlining the peculiarities of legal framework of such cooperation. The conclusion is made that the cooperation between the two parties in the energy sector leans on the framework rather than binding legal agreement, which allows both parties to develop relations in the energy sector as mutually beneficial projects based on the market principles.

Viability of Commodity Exchange in Bhutan: Assessing Challenges and Benefits

This paper investigates the viability of commodity exchange in Bhutan and identifies its essential pre-conditions. Challenges and benefits are enumerated using exploratory and qualitative research with open-ended and semi-structured interviews. Bhutan represents an emerging South-Central Asian country successful emergence of which into the global arena in the last fifty years could serve as an example for other small and developing markets. The results of this study put challenges for farmers in two categories, before and after harvest. All post-harvest challenges can be addressed through an established commodity exchange and its three pre-conditions are essential to the development of commodity exchange in Bhutan.

Full-Length Genome and Partial Viral Genes Phylogenetic and Geographical Analysis of Dengue Serotype 3 Isolates.

Dengue fever is among the most common vector-borne diseases. Dengue virus (DENV), responsible for dengue fever as well as dengue hemorrhagic fever, belongs to the genus flavivirus and family Flaviviridae. Flaviviruses infect various vertebrate species and arthropods and are also responsible for diseases in birds, wild animals, and primates. DENV consists of a single-stranded, positive-sense RNA genome ~11 kb in size. Complete genome and partial gene sequences of geographically distinct DENV-3 strains were retrieved from the GenBank database. The evolutionary divergence of the 33 whole-genome and individual gene sequences of the nucleotides and amino acids of DENV-3 strains were generated with the maximum likelihood (ML) and Bayesian phylogenetic study (BEAST) methods using the MEGA 7 software. The genome size varied from 10,484 to 10,724 nucleotides among the strains with distinct geographical backgrounds belonging to Central America, South-Central Asia, and Eastern Asia. A phylogenetic analysis of the nucleotide and amino acid sequences of these DENV-3 isolates revealed extensive differences in the topologies due to PrM/M, NS1, NS2B, and NS3 genes. These results suggest substantial variation in the evolutionary pathways of the studied genes and genomes.

Genetic and biological characterization of Newcastle disease viruses circulating in Bangladesh during 2010-2017: further genetic diversification of class II genotype XIII in Southcentral Asia.

Newcastle disease virus (NDV) is endemic in Bangladesh and is a major threat to commercial poultry operations. While complete fusion (F) genes are recommended for molecular characterization and classification of NDV isolates, heretofore, only partial F gene data have been available for Bangladeshi NDVs. To this end, we obtained the full-length F gene coding sequences of 11 representative NDVs isolated in Bangladesh between 2010 and 2017. In addition, one of the viruses (MK934289/chicken/Bangladesh/C161/2010) was used in an experimental infection of chickens to establish the viral pathotype and study gross and microscopic lesions. Phylogenetic analysis provided evidence that all studied Bangladeshi isolates belong to genotype XIII.2 of class II NDVs. Six of the viruses were isolated between 2010 and 2017 and grouped together with isolates from neighbouring India during 2013-2016. Another four Bangladeshi isolates (2010-2016) formed a separate monophyletic branch within XIII.2 and showed high nucleotide distance from the isolates from India and the other six Bangladeshi viruses within the sub-genotype; however, none of these groups fulfils all classification criteria to be named as a separate sub-genotype. The eleventh Bangladeshi virus studied here (C162) was genetically more distant from the remaining isolates. It out-grouped the viruses from sub-genotypes XIII.2.1 and XIII.2.2 and showed more than 9.5 % nucleotide distance from all genotype XIII sub-genotypes. This isolate may represent an NDV variant that is evolving independently from the other viruses in the region. The experimental infection in chickens revealed that the tested isolate (C161) is a velogenic viscerotropic virus. Massive haemorrhages, congestion and necrosis in different visceral organs, and lymphoid depletion in lymphoid tissues, typical for infection with velogenic NDV, were observed. Our findings demonstrate the endemic circulation of sub-genotype XIII.2 in Southcentral Asia and further genetic diversification of these viruses in Bangladesh and neighbouring India. This constant evolution of the viruses may lead to the establishment of new genetic groups in the region. Additional historical and prospective virus and surveillance data from the region and neighbouring countries will allow a more detailed epidemiological inference.

Transformative Impacts of Globalization on the Economy of South Caucasus and Central Asia

Research background: The disappointing economic results of the global economic crises, which brought macroeconomic instability, increasing inequality, are often understood as results of globalization. In this article, besides the positive effects, the many unavoidable negative impacts of globalization on the South Caucasus and Central Asia region are discussed. It is shown that responsibility for the economic crisis is not entirely globalization but a combination of the raw material based economy, together with incorrect trade policy. In this article, an alternative view of globalization is offered, including diversification policy challenges. It also explores the main tools of dissemination of globalization, which has created many new opportunities for business in the region. Purpose of the article: The aim is to find out to what extent the countries are involved in international integration, comparative analysis transformative impacts of globalization. Methods: The methods of comparative analysis and systematization of scientific approaches were employed. The research contains an analysis of the region's position in the international trade and investment. Findings & Value added: The region has to concentrate on a new picture of the multipolar world. In the region countries, the processes of globalization were accelerated after the countries became a member of WTO, ADB and integration into the international relations. The findings in general correspond with the trends in emerging markets that the process of globalization is gradually turning into functional mechanism of competitiveness, but there are some differences. The impacts of globalization process are progressively increasing, also there are new unforeseen impacts evolving.

The Genus Lagochilus (Lamiaceae): A Review of Its Diversity, Ethnobotany, Phytochemistry, and Pharmacology.

The genus Lagochilus (Lamiaceae) is native to Central, South-Central, and Eastern Asia. It comprises 44 species, which have been commonly used as herbal medicines for the treatments of various ailments for thousands of years, especially in Asian countries. This review aims to summarize the chemical constituents and pharmacological activities of species from the genus Lagochilus to unveil opportunities for future research. In addition, we provide some information about their traditional uses, botany, and diversity. More than 150 secondary metabolites have been reported from Lagochilus, including diterpenes, flavonoids, phenolic compounds, triterpenoids, iridoid glycosides, lignans, steroids, alkaloids, polysaccharides, volatile, non-volatile and aromatic compounds, lipids, carbohydrates, minerals, vitamins, and other secondary metabolites. In vitro and in vivo pharmacological studies on the crude extracts, fractions, and isolated compounds from Lagochilus species showed hemostatic, antibacterial, anti-inflammatory, anti-allergic, cytotoxic, enzyme inhibitory, antispasmodic, hypotensive, sedative, psychoactive, and other activities.

Identification of a subpopulation of chemoresistant cancer cells with adult stem cell properties and embryonic transcription factors in oral squamous cell carcinoma

Background: In South-central Asia, oral cancer ranks among the three most common types of cancer. India alone accounts for 86% of the total oral cancer figures globally. Cancer stem cells (CSCs) are thought to give rise to differentiated tumor cells and to predict tumor recurrence and metastases. This study designed to characterize the CSCs derived from oral squamous cell carcinoma and its identification of correlation with embryonic transcriptional potential. Materials and Methods: Tumor (microscopically ~80% of their areas occupied by tumor cells) and normal counterpart (normal paired noncancerous matched tissue) samples from each histologically confirmed cases of oral squamous cell carcinoma (OSCC) were undertaken in this study. Isolation of stem cells using anti-CD133-positive selection. Expression levels of stem cell surface markers were assessed by flow cytometer. The immunoprofile of these markers was correlated with sex-determining region Y-box 2 (SOX-2), octamer-binding transcription factor 4 (OCT4), and NANOG. The tissue samples of OSCC were studied to identify the localization pattern for CSCs using fluorescence microscopy. Results: Histologically, SOX-2 expression has been identified at all zones exhibiting dysplasia. Isolated CD133+ cells showed differential expression pattern with embryonic transcription factors in tumor cells but not in normal counterpart, which depicts their cancer stemness. Flow cytometry analysis exhibited that SOX-2/OCT4/CD44+with CD133 positive stemness in OSCC malignant tissues was identified to be the best marker for OSCC prediction of the disease. Conclusion: The isolated subpopulation CD133+ cells possess the characteristics of both stem cells and malignant tumors. The findings show that elevated levels of CD133 lead to OSCC invasiveness and metastasis, associated with the upregulation of embryonic and stemness markers. Hence, these tumors may be controlled by restricting the expression of CD133, CD44, OCT4, and SOX2 or by disrupting the molecular pathways that are altered in CSCs.

Ethnic differences in the impact of gestational diabetes on macrosomia

Background Previous studies reported an ethnic disparity in gestational diabetes mellitus-associated birth outcomes, with some suggesting that macrosomia increases to a lesser extent in groups at high risk, the opposite of the pattern observed by others. Our aim was to evaluate ethnic variation in the impact of gestational diabetes mellitus (GDM). Methods A case-control study evaluating pregnancy outcomes was conducted in women with and without GDM from 5 ethnic groups. Data on GDM were collected between January 2004 and July 2017. Women giving birth between May 2013 and July 2017 in whom pre-existing diabetes had been ruled out served as controls. A multivariate logistic regression analysis was performed to determine factors independently associated with macrosomia. Results 852 GDM women and 3,803 controls were included. In Caucasian and East-Asian women excessive gestational weight gain (OR 2.273, 95% CI 1.364-3.788 and OR 3.776, 95% CI 0.958-14.886) was an independent predictor of macrosomia. In Latin-American and Moroccan women, obesity (OR 1.774, 95% CI 1.219-2.581 and OR 1.656, 95% CI 1.054-2.601), GDM (OR 2.440; 95% CI 1.048-5.679 and OR 3.249, 95% CI 1.269-8.321) and gestational weight gain but only for Latin-American women (OR 2.365, 95% CI 1.039-5.384) were associated with macrosomia. In South-Central Asian women, only GDM was associated with macrosomia (OR 3.701, 95% CI 1.437-9.532). Conclusions GDM is an independent predictor of macrosomia in Latin-American, South-Central Asian and Moroccan women but not in Caucasian or East-Asian women in whom other factors play a more important role.

South Caucasus Region in the context of new geopolitical realities: &amp;quot;Transcaucasia&amp;quot; or &amp;quot;Greater Middle East&amp;quot;

The events taking place on the periphery of the Heartland show a clear connection between the processes in the South Caucasus and Central Asia. The fact is that the independent republics (recognized and unrecognized) must still take their place in the new world order, as demonstrated by the turbulent 2020 in the Caucasus and the rapid changes in Central Asia (Tajikistan, Kyrgyzstan, Afghanistan). All these plots have their own logic and content. In this article, we will pay more attention to the South Caucasus, the countries of which, despite their long-term neighborhood, exist in various regional, cultural and political spaces with all its consequences.