Africa, conceptually, geographically, politically, economically, religiously and socially is in bondage and this bondage is South Africa has one of the worst youth unemployment problems in the world. The high rate of youth unemployment results in multi-dimensional range of social challenges that negatively affect the wider community and economy. Social workers in non-governmental organisations (NGOs) are adopting economic strengthening programmes (ESP) to empower unemployed youth. However, factors that are key to determining success of ESP are not precisely understood. The study utilised qualitative case study research design. Data was collected using in-depth interviews from 30 purposively selected youth aged 15–24 years, 6 NGO practitioners and 5 Department of Social Development (DSD). The Ubuntu philosophy was used as a theory for analysing and interpreting data. Ethical clearance was obtained from the University of Fort Hare. The aim of the study was to explore the determinants of youth’s success in ESP in South African NGOs. Findings established that lack of access to start-up finance, poor links to strategic partnerships and mentorship platforms were inhibiting factors for youth to establish successful enterprises. The study recommends social workers and NGOs to merge efforts and resources with other stakeholders to foster implementation of effective ESP in marginalised communities. How to reference using ASWNet style: Zibengwa, E. & Tanga, P. T. (2023). Building economic strengthening programmes for youth in South Africa: determinants of success and failure. African Journal of Social Work, 13(3), 325-332. https://dx.doi.org/10.4314/ajsw.v13i6.6 Visit journal website: https://ajsw.africasocialwork.net