We determined the main parameters of the source rupture process of intermediate- and deep-depth earthquakes occurring in the Peru–Brazil–Bolivia border region and northern Chile. The parameters of depth, fault-plane orientation, scalar seismic moment, slip distribution, and radiated seismic energy are obtained from seismograms. We selected 15 intermediate-depth earthquakes (100 km < h < 300 km) and 10 very deep earthquakes (h > 500 km) with magnitudes MW ≥ 6.0. For most events, the slip distribution over the rupture plane shows a single asperity, and the source time function presents a simple pulse. There are differences between intermediate-depth and deep earthquakes. The rupture areas, maximum slip and source time function (STF) duration are larger for intermediate-depth events than for deep events. Additionally, the STF’s show a sharper increase for deep earthquakes. The scaled radiated seismic energy shows larger values for deep depth events. The stress regime pattern derived from the obtained focal mechanism agrees with the geometry of the subduction of the Nazca plate. At intermediate depths, in the northern area up to 12°S, the stress pattern corresponds to a horizontal extension, while in the southern area, the tension axes dip at an angle of 30°. At deep depths, the stress regime corresponds to vertical compression in the north and dips of approximately 45° in the south.