Nanomaterials have attracted extensive relevance from researchers and scientists around the globe because of their unique thermo-physical features and ample potential advantages and utilizations in crucial areas, for illustration, biomedicine, electronics, energy, vehicles and aerospace. This attempt accounts magnetohydrodynamics and chemical reaction consideration in couple-stress nanomaterial confined by convectively heated vertical surface. Flow is mixed convective and thermally radiative. Brownian motion, heat generation, thermophoresis, Robin conditions and transpiration are considered for formulation. Boundary-layer expressions representing couple-stress liquid are implied utilizing transformation procedure. The obtained nonlinear expressions are tackled analytically by implementing series solution methodology (known as homotopy analysis method (HAM)). Convergence of analytical solutions is authenticated arithmetically (i.e., via table) and by drawing ℏ− curves. In addition, the significant parameters occurring in dimensionless expressions are addressed graphically. Our findings indicate retardation in flow when suction variable is augmented. Transfer of heat is higher for radiation and heat source parameters. Nanoparticles concentration decays for larger estimations of destructive reaction factor while it upsurges for generative reaction factor.