This study aims to enhance the solubility and bioavailability of cilnidipine as a dual L/N-type calcium channel blocker for hypertension using proniosomes. Proniosomes are dry powders that turn into niosomes when they come into contact with water, improving drug encapsulation and stability. Different concentrations of Span-60, cholesterol, and sorbitol were tested in the Box-Behnken design. The entrapment efficiency, particle size, zeta potential, thermal characteristics, crystalline structure and in-vitro drug release were evaluated for 17 formulations. Entrance effectivity was highest in F3 at 71.83%, while a controlled released rate of over 85.28% was observed within 12 hours. The median particle size showed a moderate stability of -11.2 mV with zeta potentials indicating this fact (902.7 nm). When, cilnidipine was inserted into proniosome systems, considerable changes occurred both thermally and crystallinity-wise according to DSC as well as XRD measurements were taken during an experiment where various mathematical models showed first-order kinetics dominated among other processes involved in drug release along Higuchi’s Equation.