Somatic and mental health and stress factors of physicians became an issue of growing interest in both national and international investigations. Our aim is to give an overview of the mental state of Hungarian physicians. Cross-sectional, quantitative survey on a representative sample of Hungarian physicians (n = 4784). The control group was formed by the population group of a national survey conducted by "Hungarostudy 2013" (n = 2000). Suicidal thoughts (18.8% vs. 9.6%, p < 0.001), the scores of Somatic Symptom Scale (PHQ-10, 20.4% vs. 13.6%, p < 0.001) were significantly higher among physicians. The suicidal attempts (1.9% vs. 3.5%, p = 0.053) and BDI depression scores (7.9% vs. 29.5%, p < 0.001) were significantly higher in the control group. High Perceived Stress Scale (PPS) scores occurred in 43.3% of the physicians sample, and 43.4% of them had high scores in the Athenian Insomnia Scale (AIS). The young (< 35) female physicians showed significantly higher rates of suicidal thoughts, higher scores of PHQ and PPS. In the young female cohort, the AIS scores were significantly higher than of the other physicians. Mental health of physicians (sleep disorders, suicidal thoughts and psychosomatic symptoms) showed poorer results than the population data. BDI scores and the rate of suicidal attempts showed favourable trends. The next step in the research of physicians' mental health is to investigate the most serious risk factors, and to refine the preventive tools.