Alcoholic Solvents Research Articles

Low-cost and Non-flammable Eutectic Electrolytes for Advanced Zn-I2 Batteries.

As a burgeoning electrolyte system, eutectic electrolytes based on ZnCl2 /Zn(CF3 SO3 )2 /Zn(TFSI)2 have been widely proposed in advanced Zn-I2 batteries; however, safety and cost concerns significantly limit their applications. Here, we report new-type ZnSO4 -based eutectic electrolytes that are both safe and cost-effective. Their universality is evident in various solvents of polyhydric alcohols, in which multiple -OH groups not only involve in Zn2+ solvation but also interact with water, resulting in the high stability of electrolytes. Taking propylene glycol-based hydrated eutectic electrolyte as an example, it features significant advantages in non-flammability and low price that is <1/200 cost of Zn(CF3 SO3 )2 /Zn(TFSI)2 -based eutectic electrolytes. Moreover, its effectiveness in confining the shuttle effects of I2 cathode and side reactions of Zn anodes is evidenced, resulting in Zn-I2 cells with high reversibility at 1 C and 91.4 % capacity remaining under 20 C. After scaling up to the pouch cell with a record mass loading of 33.3 mg cm-2 , super-high-capacity retention of 96.7 % is achieved after 500 cycles, which exceeds other aqueous counterparts. This work significantly broadens the eutectic electrolyte family for advanced Zn battery design.

Equilibrium solubility, solvent effect, equation correlation, and thermodynamic properties of cyclododecanone in twelve organic solvents

The solubility of cyclododecanone (CDON) was determined in twelve solvents containing acetonitrile, acetone, toluene, ethyl acetate, cyclohexane, 1,2-dichloroethane, methanol, ethanol, n-propanol, i-propanol, n-butanol and i-butanol. The temperature range for the remaining solvents used in the experiment was 278.15–313.15 K, except for cyclohexane (283.15–313.15 K). The CDON solubility in solvents measured increased with growing temperature. The CDON solubility varies considerably in different solvents. Among the single solvents selected, CDON was most soluble in 1,2-dichloroethane and least in acetonitrile. The solubility in 1,2-dichloroethane is about 2–3 times higher than in acetonitrile. The carbonyl oxygen of CDON readily combines with alcoholic solvents to form hydrogen bonds. Hansen solubility parameters (HSP) and the physiochemical properties of the solvents explain the solvent effect in diverse solvents. To understand CDON dissolution, the electrostatic potential energy surfaces of CDON and the solute–solvent interactions were analyzed at the molecular level on the basis of density functional theory (DFT). Analysis of solvation effects revealed that variations in the CDON dissolution are influenced by a combination of factors rather than a single one. In addition, the Van't Hoff equation, modified Apelblat equation, Yaws equation, λh equation, Wilson model and Jouyban model were utilized to correlate the experimentally obtained value. The computational data show that the ARD (0.88%) and RMSD (0.24%) of Wilson model are the smallest among the selected equations with the best correlation. The apparent thermodynamic properties of CDON dissolution were further accounted for Van't Hoff equation, and the CDON dissolution was observed to be endothermic and entropy-driven.

Hydrogenation of CO2 to MeOH Catalyzed by Highly Robust (PNNP)Ir Complexes Activated by Alkali Bases in Alcohol.

Despite receiving significant attention, well-defined homogeneous complexes for hydrogenation of carbon dioxide (CO2) to methanol (MeOH) are scarce and suffer issues of low catalyst turnover numbers (TONs) at high catalyst concentrations and deactivation in the presence of CO and at elevated temperatures. Herein, we disclose a system deploying sterically demanded (PNNP)Ir complexes for a sustained activity for hydrogenation of CO2 to MeOH at temperatures ∼200 °C in an alcohol solvent. Through reaction optimization, we achieved a TON of ∼9000 for MeOH formation, which exceeds most active homogeneous systems reported to date, and robustness on par with or exceeding most reactive systems utilizing amine additives was demonstrated. The key to achieving sustained catalyst turnover for the system was utilizing a catalytic amount of an alkali base additive, which serves the dual purpose of facilitating more efficient outer-sphere reduction of CO2 and HCO2Et and enhancing the selectivity of MeOH over in situ formed CO.

Modulating the Microenvironment of Silanols in Pure-Silicon Zeolites for Boosting Vapor-phase Beckmann Rearrangement of Cyclohexanone Oxime.

Vapor-phase Beckmann rearrangement of cyclohexanone oxime (CHO) to ε-caprolactam (CPL) is still difficult to commercialize at the industrial scale due to its relatively low catalytic activity and poor lifetime. Herein, we synthesized a series of pure-silicon zeolites (including MFI, MEL, and -SVR) with three-dimensional 10-member-ring topolgies, diverse silanol status, and hierarchical porosity to investigate the synergistic effects of inner diffusivity and reactivity. S-1 zeolite of MFI-type topology with plentiful silanol nests exhibits a more preferable catalytic performance in terms of CHO conversion (99.7%) and CPL selectivity (89.7%), much higher than those of MEL- and -SVR-type zeolites mainly due to their diverse silanol distribution. With the construction of hierarchical porosity, S-1-P shows improved CPL selectivity of 94.1% owing to the enhanced diffusivity to shorten the retention time of the reactant and product molecules. The reaction mechanism and network have been further revealed by density functional theory (DFT) calculations and experimental designs, which indicate that silanol nests are major active sites due to their suitable interaction with CHO rather than terminal silanols. Particularly, the microenvironments of silanols can be modulated by alcohol solvents, ascribed to their different charge transfer and steric hindrance. Consequently, S-1-P shows superior CPL selectivity of 97.3% in ethonal solvents, which have higher adsorb energy of -0.627 eV with silanol nests than other alcohols. The present study not only provides a fundamental guide for the design of zeolite catalysts but also provides a reference for modulating the microenvironment of active sites according to the catalytic mechanism.

Low‐cost and Non‐flammable Eutectic Electrolytes for Advanced Zn‐I2 Batteries

AbstractAs a burgeoning electrolyte system, eutectic electrolytes based on ZnCl2/Zn(CF3SO3)2/Zn(TFSI)2 have been widely proposed in advanced Zn‐I2 batteries; however, safety and cost concerns significantly limit their applications. Here, we report new‐type ZnSO4‐based eutectic electrolytes that are both safe and cost‐effective. Their universality is evident in various solvents of polyhydric alcohols, in which multiple −OH groups not only involve in Zn2+ solvation but also interact with water, resulting in the high stability of electrolytes. Taking propylene glycol‐based hydrated eutectic electrolyte as an example, it features significant advantages in non‐flammability and low price that is &lt;1/200 cost of Zn(CF3SO3)2/Zn(TFSI)2‐based eutectic electrolytes. Moreover, its effectiveness in confining the shuttle effects of I2 cathode and side reactions of Zn anodes is evidenced, resulting in Zn‐I2 cells with high reversibility at 1 C and 91.4 % capacity remaining under 20 C. After scaling up to the pouch cell with a record mass loading of 33.3 mg cm−2, super‐high‐capacity retention of 96.7 % is achieved after 500 cycles, which exceeds other aqueous counterparts. This work significantly broadens the eutectic electrolyte family for advanced Zn battery design.

Design of polarity-dependence orange emission multifunctional carbon dots for water detection and anti-counterfeiting

In this work, polarity-dependence orange emission multifunctional carbon dots (o-CDs) were designed for water detection in organic solvents and anti-counterfeiting. The o-CDs were readily fabricated by a one-step hydrothermal method with citric acid and p-aminoazobenzene as precursors. The o-CDs possess bright orange fluorescence, good photochemical stability, and polarity-dependence characteristic. With the increase of polarity, the emission peak of o-CDs gradually red-shifted. Meanwhile, with the increase of water content in organic solvent, the fluorescence intensity of o-CDs decreased significantly and the emission peak position gradually red-shifted. This is due to the specific water-fluorophore interaction (particularly hydrogen bond effects), part of o-CDs gathered, making the carbonized cores suffer from π–π stacking and reduced the transition energy gap. Based on this, a fluorescence sensing platform with satisfactory recoveries and relative standard deviation was constructed to detect water content in real alcohol solvents. Furthermore, the o-CDs were further designed into fluorescent ink and prepared fluorescent flexible films, realizing information encryption and solid-state fluorescence. This work opens up a possibility for the development of polarity-dependence orange emission nanomaterial based on CDs for water detection, anti-counterfeiting, and solid-state fluorescence.

Solid-liquid phase equilibrium and thermodynamic properties analysis of Bazedoxifene acetate in fifteen kinds of mono-solvents

Crystallization is widely used for the isolation and purification of active pharmaceutical ingredients (APIs) in the final manufacturing stage. Bazedoxifene (BZD) acetate, classified as a third-generation selective estrogen receptor modulator, is employed in the treatment of postmenopausal osteoporosis. This work reports the equilibrium solubility data of BZD acetate in fifteen different mono-solvents, including methanol, ethanol, n-propanol, i-propanol, n-butanol, ethyl formate, methyl acetate, ethyl acetate, acetone, 2-butanone, cyclohexanone, tetrahydrofuran (THF), 2-methyltetrahydrofurane (2-MeTHF), 1,4-dioxane and acetonitrile (ACN), within the temperature range “T = 283.15–323.15 K” under p = 0.1 MPa. The solubilities of BZD acetate in various solvents increase with increasing temperature. Among the alcoholic solvents, the solubility order is as follows: methanol > ethanol > n-propanol > n-butanol > i-propanol. In esters solvent, the solubility of BZD acetate decreases in the following order: methyl acetate > ethyl acetate > ethyl formate. For ketones solvent, the solubility decreases in the following order: cyclohexanone > acetone > 2-butanone. The maximum value of BZD acetate solubility was 0.011 mol·mol−1 in tetrahydrofuran at T = 323.15 K, but the least data was found in ethyl formate at 283.15 K. Four thermodynamic models, i.e., the Yaws model, modified Apelblat model, λh model, and Wilson model were applied to fit the solubility data of BZD acetate in different solvents. Among them, the Wilson model represents the most accurate fitting outcomes. Finally, the thermodynamic functions of mixing (including enthalpy, entropy, and Gibbs energy) were calculated, and the results indicate a mixing process that is both spontaneous and driven by entropy. The solubility data, correlated models, and derived thermodynamic functions present essential thermodynamic fundamentals for the industrial production of BZD acetate crystallization, facilitating efficient separation and purification.

Quality analysis of oil recovered from used locomotive engine oil using ultrasound-assisted solvent extraction

Herein, we present a process for recovering used locomotive engine oil using ultrasound-assisted extraction and sustainable organic solvents. We evaluated the quality of the oil recovered from used locomotive engine oil through ultrasound-assisted extraction or mechanical stirring. The extraction process involved the direct application of ultrasound (25 °C, 24 kHz, amplitude 20%) or mechanical stirring (225 rpm, 25 °C) to a mixture of used locomotive engine oil and alcoholic solvents (ethanol, propan-2-ol, 2-methlypropan-1-ol, and butan-1-ol) for 0.5, 1, and 5 min. With ultrasound (5 min), the yield of butan-1-ol was the highest (91.4 wt%), followed by that of 2-methylpropan-1-ol (79.4 wt%), propan-2-ol (12.1 wt%), and ethanol (3.6 wt%). With mechanical stirring (5 min), the yield of butan-1-ol was the highest (88.3 wt%), followed by that of 2-methylpropan-1-ol (59.8 wt%), propan-2-ol (9.54 wt%), and ethanol (2.3 wt%). The kinematic viscosities of the recovered oils extracted with 2-methylpropan-1-ol and butan-1-ol were 126.0 and 132.7 mm2 s−1, respectively, which were close to the kinematic viscosity of fresh locomotive engine oil (150.6 mm2 s−1). The recovered oil had decreased Ca, Cr, Fe, Mo, and Na concentrations. The proposed recovery is a promising approach for the support and intensification of used locomotive engine oil treatment.

Isolation, Modification and Characterization of Cellulose from Corn Husk Waste of Puncak‐Bogor

AbstractCellulose and its derivatives are important industrial raw materials for their advantages, including abundance, biodegradable, environmentally friendly, biocompatible, and good mechanical and thermal properties. This study aims to isolate and modify cellulose from corn husk waste of Puncak‐Bogor, Indonesia for improving the characteristics and usability of corn husk cellulose. The cellulose of corn husk was isolated with the delignification and bleaching process, by using sodium hydroxide (NaOH) and hydrogen peroxide (H2O2), respectively. The modification of cellulose was carried out using alkaline and etherification stages with monochloroacetic acid (MCA) in an isopropyl alcohol solvent. The presence of a peak at 898 cm−1 on the bleaching product confirmed the β‐(1,4)‐glycosidic bond of pure cellulose, while the peak at 1612.49 cm−1 on the modified cellulose product confirmed the carbonyl group of carboxymethyl cellulose. Cellulose isolated from corn husk has a crystallinity index of 76.4 % (2nd bleaching product), while CMC is 29.97 %. Cellulose (2nd bleaching product) starts to decompose at 271.8 and finishes at 642.63 °C, while CMC shows a lower decomposition temperature of 248.47 and 628.17 °C. Based on the results, it can be concluded that cellulose and CMC from Puncak‐Bogor's corn husk waste were obtained through the isolation method and modification stages in this research, respectively.

Effect of Alcohol Extract, Volatile Oil and Alkaloid Isolated from Capsicum frutescens L. Fruits on Candida albicans

This study involved extracting the of alcohol extract, volatile oil and alkaloid isolated from Capsicum frutescens L. fruits on Candida albican,. It also involved test a phytochemical screen and determine the percentage yield of the alcohol extract, volatile oil and alkaloid, Capsicum annuum L. was collected from the Karbala City, that approximately 24 hours to extract using Soxhlet apparatus with 400 ml of Methanol Alcohol Solvent in a 1000 ml Flask, and evaporation by rotary evaporation 40C° for drying, and storage at 4C° until use, indicate results that Percentage yield of Alcohol and volatile oils extracted was (3.8% and 4.1%), showing alcohol extract that high positive reaction with used reagent, Alkaloid, Phenol, Glycoside, and Flavonoid, Saponin and tannin. While volatile oil extract revealed positive results for Alkaloid, Glycoside, Flavonoid, tannin and Phenol while and Saponin indicate negative results. The antifungal effects of alcohol extract, volatile oil and alkaloid depended on different concentration, The alcohol extract’s inhibition zone measured 11.12 mm and had a 20 mg/ml concentration, while concentration 40 mg/ml was inhibition zone 12.34mm while concentration 80 mg/ml was inhibition zone 13.65mm, while concentration 100 mg/ml was inhibition zone 15.76 mm, while The inhibition zone of volatile oil extract was 12.76 mm in concentration 0.5 mg/ml, while concentration 0.1 mg/ml was inhibition zone 14.75mm, while concentration 1 mg/ml was inhibition zone 15.76, while concentration 2 mg/ml was inhibition zone 18.65 mm, Alkaloid’s inhibition zone measured 12.34 mm at concentrations of 1 mg/ml and 14.13 mm in those of 5 mg/ml. while concentration 10 mg/ml was inhibition zone 15.98mm, while concentration 15 mg/ml was inhibition zone 20.12 mm. The aim from this study is to determine the best extract (alcohol extract, volatile oil and alkaloid ) isolated from Capsicum frutescens L. fruits on Candida albican.

Simultaneous use of microfluidics, ultrasound and alcoholic solvents for improving CO2 desorption process

Simultaneous use of microfluidics, ultrasound and alcoholic solvents for improving CO2 desorption process

1D iron vanadate-reduced graphene oxide nanorod composite for efficient oxidative esterification of aldehydes

In this paper, we report a facile and one-pot hydrothermal synthesis of FeVO4-rGO nanorod composite and its application as a heterogeneous catalyst in the oxidative esterification reaction of aldehydes using hydrogen peroxide oxidant. The nanomaterial is thoroughly characterized by different techniques, namely, XPS, FESEM, elemental mapping, XRD, Raman, HRTEM, etc. The as-prepared nanocatalyst shows good activity for the controlled base-free oxidative esterification of various aromatic aldehydes in alcohol solvents under refluxing conditions, achieving good yields of the desired esters. Furthermore, the substrate scope was explored over a wide array of substituted aromatic aldehydes with diverse electron-withdrawing and electron-donating groups in the phenyl ring. The presence of heterogeneous interfaces-induced properties in the nanorod composite results in synergistic effects to provide good catalytic performance. Thus, binary transition metal oxide-reduced graphene oxide-based nanocomposite as a nanocatalyst can open doors for efficient and sustainable esterification of aromatic aldehydes and aliphatic alcohols under oxidative conditions.

From Cycloalkanols to Heterocycles via Nitrogen Insertion.

A variety of cyclic alcohols are found to undergo nitrogen insertion by subjection to O-mesitylsulfonylhydroxylamine. Critical to a successful process is the use of fluorinated alcoholic solvents, which ensures sufficient substrate activation to allow engagement with the ambiphilic aminating agent. This transition-metal-free nitrogen insertion provides access to a variety of medicinally relevant heterocycles such as pyrrolidenes, quinolines, and benzazepines (24 examples). Furthermore, combination with a photochemical Norrish-Yang-type cyclization allows an unprecedented access to indoles from ortho-substituted acetophenones.

A hybrid Electro-Driven adsorption and degradation system for antibiotics and dyes based on composite tablets composed of deep eutectic solvent-functionalized nanomaterials

In this study, a unique hybrid system was designed and developed for the continuous electro-driven adsorption and degradation of typical antibiotics together with dyes, which were based on immobilized deep eutectic solvent of thymol-benzyl alcohol on zeolitic imidazolate framework-8 (ZIF-8) and multi-walled carbon nanotubes (MWCNTs). After prepared with simple and mild method, the composite tablets were comprehensively characterized by various ways. Due to their large specific surface area and high thermal stability, the maximum adsorption efficiencies of sulfa pyrimidine (SDZ), ciprofloxacin (CIP), methylene blue (MB), malachite green (MG) and crystal violet (CV) were 90.52%, 85.18%, 94.89%, 94.61% and 96.18%, respectively. The adsorption efficiency of chlortetracycline (CTC) was only 9.66% due to the existence of competitive adsorption at the same condition. In addition, the high adsorption efficiency was validated by the real water samples. Multiple interactions including electrostatic interaction, π-π, H-bonding in the adsorption process were all revealed by the kinetics and isotherms studies, spectral analysis and molecular simulation. At last, the composite tablets were easily recycled after elution process, meanwhile the adsorbed antibiotics and dyes were almost completely degraded during the subsequent electrochemical oxidation process. It was expected to provide valuable insights to the combination of the new applied form of green solvents and electro-driven integrated technology as well as synergistic effects deriving from advantages of different functional materials for multi-task process.

COMPONENT COMPOSITION OF INKS, PAINTS AND DYES AS AN IMPORTANT COMPONENT OF DOCUMENT PROTECTION AGAINST COUNTERFEITING

This article analyzes the component composition of inks, paints and dyes, and also gives a general description of one or another type of ink or dye and a classification of some of them. The historical aspect of the manufacture of inks and their components is highlighted. Writing ink was first made in ancient Egypt and China around 2500 BC. The features of paints depending on the type of printing (high, gravure, flat offset, screen) are studied and examples of their application are given. Flat offset inks used in newspapers are usually simple in composition. As for letterpress, although this type is gradually being replaced by other printing processes, it is still used in the production of money, most paper-based forms in printing serial numbers, etc. Gravure inks are similar to flexographic inks, except that ketones and aromatic hydrocarbons can be used as solvents, allowing much greater freedom in the choice of binders. This type of ink for inkjet printing, such as solvent ink, is considered in detail. Solvent ink is a complex physical and chemical system for inkjet printing, consisting of pigment, polymer, film former, solvent and special additives. The structural composition of solvents is characterized, which, getting on paper, undergoes a number of changes over a fixed period of time, as a result of which the dye dries on paper. Ethanol, benzyl alcohol and many other solvents can also be used as carriers. The choice of solvent or solvents often depends on the properties of the writing instrument. The so-called «invisible» ink (UV ink, thermosetting ink, etc.) was studied separately as a kind of protective element. This type of ink is mainly used in steganography, anti-counterfeiting and currency security features, packaging authenticity indicators, brand protection, and secret messages. Conclusions are drawn, emphasizing that understanding the principle of operation of one or another element of protection allows forensic experts of forensic technical examination of documents to effectively identify forgery.

Hydrophobic electrospun membrane of peppermint oil loaded zein with coating of methyltriethoxysilane for active packaging

Zein electrospun nanofibers are widely used as the vehicles to load bioactive entities for release control; however, the water absorption of zein always restricts their applications in food preservation. In this work, an active hydrophobic membrane of peppermint oil (PO) loaded zein (ZN) with coating of methyltriethoxysilane (MTES) was developed for pork preservation. The fiber matrix of ZN was use for PO incorporation. The secondary structure of ZN and the feature of the relevant fibers are dependent on solvents of acetic acid and ethyl alcohol. In the composite structure, PO is hydrogen-bonded with ZN matrix; while the coating of MTES is bonded with fiber matrix by Si–O–C. The well-controlled release of PO predominantly follows the law of Fickian diffusion, endowing the membrane good antibacterial activity and antioxidant activity. The coating of MTES has no obvious influence on the bioactivities but provides the membrane outstanding hydrophobicity with water contact angle of 138 ± 5°. ZN-PO30-MTES can extend shelf life of pork by 100% (i.e., 24 h) at 25 °C, demonstrating its potential in food active packaging.

Integrated capture and solar-driven utilization of CO2 from flue gas and air

Integrated capture and solar-driven utilization of CO2 from flue gas and air

Effect of ZnO in various alcohols on photoelectric characteristics of OSC

The paper presents the results of a study of the effect of alcohols on the electron transport of the ETL layer of a ZnO polymer solar cell with an inverted structure. To obtain films, zinc acetate was dissolved under the same experimental conditions in isopropanol, butanol and ethanol. According to the SEM data, it was found that the use of various alcohol solvents in the synthesis of the film shows a change in the morphology of the surface. The observed changes in the interface of the surface of the films are associated with the formation of ZnO aggregates depending on the polarity used of the alcohols. It is shown that the optical width of the ZnO band gap also depends on alcohol solvents. It is shown that the aggregation of ZnO has an effect on the electron transport and efficiency of the polymer solar cell. The voltage characteristics of the solar cells FTO/ ZnO/P3HT: IC60MA/PEDOT: PSS/Ag were measured. It is shown that the smallest aggregation of ZnO is observed in Isopropanol, in which the organic cell showed the highest efficiency of converting solar energy into electrical energy. The polymer solar cell has been the efficiency 2.5 %. From the obtained ETL impedance measurement data, the ZnO based layer obtained in Ethanol has the lowest electron transport parameters. This is due to the high degree of aggregation of ZnO, as a result of which the resistance to increases of the interface ZnO/FTO. The solar cells based ZnO in Ethanol demonstrated an efficiency value of 0.9 % compared to ZnO in Butanol with an efficiency of 1.6 %.

Aktivitas Tabir Surya Ekstrak Biji Nyamplung (Chalophyllum inophyllum Linn)

This study aims to evaluate the sunscreen activity of nyamplung seed extract resulting from cold press extraction, soxletation with n-hexane solvent, and maceration with alcohol solvent. Apart from that, determining the minimum concentration of using nyamplung seed extract as a sunscreen ingredient. This study was conducted in vitro using UV spectrophotometry with the method developed by Sayre et al., (1979). The results showed that the alcohol extract of nyamplung seeds had the best sunscreen activity with an SPF of 42,499 at a concentration of 1,000 ppm in chloroform:alcohol (1:1) in the ultra protection category. Followed by n-hexane extract and cold pressed extract with SPF 39,951 and 36,349 respectively with the same concentration, solvent, and category. The higher the sample concentration, the lower the percentage of erythema and pigmentation, while the higher the SPF. The lowest concentrations of cold pressed extract, n-hexane, and nyamplung seed alcohol that meet the category of sunscreen with ultra protection were 600, 600, and 400 ppm, respectively.

Effect of Water on Direct Radioiodination of Small Molecules/Peptides Using Copper-Mediated Iododeboronation in Water-Alcohol Solvent.

Direct radioiodination of peptides using copper-mediated iododeboronation is a promising radiosynthetic method for solving issues of classical direct radiolabeling, such as toxicity of the organotin precursor (iododestannylation) or formation of radio byproducts (by electrophilic iodination of a tyrosine residue). However, the parameters for optimizing the reaction conditions for various peptides are not completely understood. In particular, considering peptide solubility, the effects of water-containing solvents on labeling efficiency should be thoroughly investigated. Herein, we describe the effect of water on copper-mediated radioiododeboronation and the key factors for ensuring the successful radiolabeling of small molecules and peptides in water-organic solvents. 125I-labeled substrates containing peptides ([125I]m/p-IBTA) were obtained with high radiochemical conversions (RCCs: >95%) using an alcohol solvent, and a decrease in these RCCs was observed with increasing water content in the methanol solvent. Additionally, when using water-methanol solvents, a difference in RCC due to the substituent effect was also observed. However, the RCCs can be improved without the use of other additives by adjusting the copper catalyst and time of the labeling reaction or by utilizing substituent effects. This study contributes to the improvement of the design of boronic peptide precursors and radiolabeling protocols using copper-mediated iododeboronation.