Abstract
A variety of cyclic alcohols are found to undergo nitrogen insertion by subjection to O-mesitylsulfonylhydroxylamine. Critical to a successful process is the use of fluorinated alcoholic solvents, which ensures sufficient substrate activation to allow engagement with the ambiphilic aminating agent. This transition-metal-free nitrogen insertion provides access to a variety of medicinally relevant heterocycles such as pyrrolidenes, quinolines, and benzazepines (24 examples). Furthermore, combination with a photochemical Norrish-Yang-type cyclization allows an unprecedented access to indoles from ortho-substituted acetophenones.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
