A new promising polyvinyl chloride embedded-thiosemicarbazide sequestering agent (PVC-TSC), was exploited to separate U(VI) from its water solution. Specifications for PVC-TSC were carried out efficaciously using respective performances such as BET, TGA, 1H NMR, SEM-EDX, 13C NMR, FT-IR, XPS, and GC–MS analyses, which assure a satisfactory synthesis. Variables like initial pH, agitation duration, temperature, starting U(VI) concentration, PVC-TSC dosage, co-existing ions, and eluting agents have all been fine-tuned by experimental optimization. In conditions of 298 K, pH 4.5, 30 min of agitation, and 0.63 × 10−3 mol/L uranium ions, the maximal sorption competence of PVC-TSC is 30 mg/g. Based on the adsorption-distribution isotherm estimation, the experimental value of 30.12 mg/g is similar to the theoretical value that Freundlich came up with. However, Langmuir's value is higher and more in line with the practical data. Modeling of the U(VI) kinetics adsorption by PVC-TSC yielded a theoretical retaining capacity of 29.66 mg/g for first-order (PFO) modeling and 32.051 mg/g for second-order (PSO) modeling, as suggested by a hybrid PFO and PSO kinetic model. By taking into account the thermodynamical factors ΔS° (−0.063 kJ/mol.K), ΔH° (−16.2 kJ/mol), and ΔG°, the adsorption evolution was anticipated to be exothermic, spontaneous, and best performed at down temperatures. From a cost perspective, eluting the loaded PVC-TSC composite with 0.5 M H2SO4 yields a 90 % efficiency rate for U(VI) ions.