The article considers an economic and mathematical model of optimal placement and determination of rational capacities of enterprises for processing solid household waste (SHW) at the regional level. The economic and mathematical model takes into account: factors that ensure the achievement of economic efficiency; ensuring environmental safety of the environment, the population of cities and towns. Environmental safety of SHW processing plants is of the utmost importance, since Crimea is a resort and recreation area. The role of state bodies in solving these urgent problems for the Crimea is considered.