The effects of different solid-solution temperature and holding time on the alloy structure and mechanical properties of alloy 718 were investigated. The results show that the grain size grows up as the solid-solution temperature elevates and the holding time prolongs. The grain size increases slowly because undissolved delta phase restrains the growth of grains when solid-solution temperature is below 1000°C, whereas the grain size increases quickly when solid-solution temperature is beyond 1050°C. At room temperature, the strength and hardness of alloy 718 decrease with solution treatment temperature increasing, however, the ductility and toughness of alloy 718 both increase, and the brittle fracture of sample turns into ductile fracture.