The jet-flow high shear mixer exhibits foreseeable advantages in intensifying diffusion-controlled solid-liquid reactions by its high-frequency mechanical impact. This study systematically investigated the influence of operational and structural parameters on solid-liquid mass transfer performance in JF-HSM. Combining experimental and simulation methods, suspension effect of solid particles in JF-HSM were assessed, and flow characteristics of particle two-phase flows were also analyzed. The results indicated that Njs was significantly influenced by rotor blade angle and stator bottom opening diameter, which increased by 1.77 and 1.47 times, respectively. The stator off-bottom clearance had a pronounced effect on kSLaSL, which increased by 90%. Furthermore, altering stator side opening ratio had minimal impact on both kSLaSL and Njs. Interestingly, acid concentration substantially affected kSLaSL, resulting in a maximum decrease of 24%, whereas Njs changed by only 3%. Correlations for kSL and Njs were established, providing theoretical guidance for applying and scaling JF-HSM in solid-liquid operations.