Sole Criterion Research Articles

Is a unified blood pressure threshold feasible in the current scenario?: Commentary on the article"130/80mmHg as a unifying hypertension threshold for office brachial, office central and ambulatory daytime brachial blood pressure": Commentary on the article"130/80mmHg as a unifying hypertension threshold for office brachial, office central and ambulatory daytime brachial blood pressure".

Is a unified blood pressure threshold feasible in the current scenario?: Commentary on the article"130/80mmHg as a unifying hypertension threshold for office brachial, office central and ambulatory daytime brachial blood pressure": Commentary on the article"130/80mmHg as a unifying hypertension threshold for office brachial, office central and ambulatory daytime brachial blood pressure".

Assessment of Nutritional Status of Under-Five Children in an Urban Area of South Delhi, India.

Introduction Malnutrition amongchildren continues to be a severe public health problem worldwide, whether in a developing country like India or a developed nation. Correct estimation of the problem is a prerequisite to planning the measures to control it. Objective To estimate the prevalence of undernutrition among children under five years of age by utilizing the Composite Index of Anthropometric Failure and the WHO growth charts. Methods From January to March 2020, 1332 children under the age of five years participated in a facility-based, descriptive, cross-sectional study at Fatehpur Beri, Urban Primary Health Center. An anthropometric assessment for each participant was done as per the WHO criteria. The data were entered into a Microsoft Office Excel spreadsheet (Microsoft Corporation, Redmond, WA) and analyzed with WHO Anthro software (WHO, Geneva, Switzerland) and a licensed version of SPSS 21 (IBM Corp., Armonk, NY). Continuous data were expressed using appropriate measures of central tendency, while categorical data were expressed in either frequency or proportions. Results The mean age of the study participants was 23.04 ± 18.24 months, and males (53.3%) were more than (46.7%) females. The prevalence of being underweight was 24.5% (327/1332), of which 24.1% (79/327) of children were severely underweight. Of the total study participants, 27.3% (362/1332) were stunted, and 17.8% (237/1332) were wasted, of which 29.1% (69/237) were severely wasted. The prevalence of anthropometric failure was 45%. Conclusions According to the findings of this study, the prevalence of undernutrition among the study participants was substantial. Furthermore, considering weight for age as the sole criterion may underestimate the true prevalence of malnutrition. The findings have critical implications for future interventions and initiatives among children in India.

Evaluation of Optic Disc Edema in Long-Duration Spaceflight Crewmembers Using Retinal Photography.

Long-duration spaceflight crewmembers are at risk for spaceflight-associated neuro-ocular syndrome (SANS). One of the earliest manifestations of SANS is optic disc edema (ODE), which could be missed using the subjective Frisén scale. The primary objective of this study is to determine the inter-rater and intrarater reliability of Frisén grade for SANS-induced ODE among a trained observer cohort. The secondary objective is to propose a standardized evaluation process for SANS-induced ODE across International Space Station Partner Agencies. Retrospective, double-blinded diagnostic study. Preflight and postflight fundus photographs were presented to subject matter experts who identified and graded ODE. Pairs of images were also compared side-by-side for disc ranking. Grader concordance was assessed for Frisén grading and disc ranking. Expert graders identified Grade 1 ODE in 17.35% of images from 62 crewmembers (9 female, mean [SD] age, 47.81 [5.19] years). Grades 2 and 3 were identified less than 2% of the time. Concordance in Frisén grades among pairs of graders was 70.99%. Graders identified a difference in preflight and postflight fundus photographs 17.21% of the time when using disc ranking. Pairs of graders had complete concordance in disc ranking 79.79% of the time. Perfect intrarater agreement between Frisén grade and disc ranking occurred 77.7% of the time. These findings demonstrate intergrader and intragrader variability when using the Frisén scale to identify SANS-induced ODE, which is typically milder in presentation than terrestrial cases of idiopathic intracranial hypertension. It is possible to miss early ODE on fundoscopy alone, making it insufficient as a sole criterion for the diagnosis of SANS. A more sensitive and objective method of surveillance is necessary to monitor international crewmembers for ODE, perhaps using a multimodal approach that includes technology such as optical coherence tomography.

Наукова особистість Іллі Кучеренка в українській граматикології

The article is devoted to the analysis of the scientific contribution of Taras Shevchenko Kyiv University professor Ilya Kucherenko to the development of the grammatical theory of word combinations and sentences, the innovative principles of classification of parts of speech, the theory of cases, the syntactic status of homogeneous clauses, the function of the preposition in a syntactic combination, the syntactic nature of phraseological units, the principles of logical consistency in definition of key concepts and mechanisms of language structure. His innovative grammatical concept lies in the application of the monocriterial principle for dividing words into parts of speech. The real meaning of the word was chosen as the sole criterion. According to their real meaning, the scientist divides all the words of the language into seven classes (noun, adjective, numeral, verb, adverb, participle, conjunction) and in each of these classes he distinguishes three levels of semantics: the level of specific semantics, the level of generalized semantics and the level of generalized indicative semantics. The article analyzes the syntactic function of the preposition in the phrase. I. Kucherenko believes that the preposition does not help the noun to implement the noun semantics, but on the contrary, it requires the noun to specify the generalized-indicative level of its semantics and is combined with the noun dependent on it by the grammatical control link. The grammarian considers stable (phraseological) compounds to be not lexical, but syntactic units, since the words in them are combined in the same way as in free word combinations. The article also examines a number of other syntactic phenomena (monosyllabic sentences, homogeneous clauses, vocative), which I. Kucherenko explains using strictly logical methods of analysis. The grammatical concept of Ilya Kucherenko is analyzed in comparison with the views of other scientists of the 60s–90s of the 20th century.

Relationship between muscle mass and muscle strength with physical performance in older adults: A systematic review.

Declining muscle mass is not always accompanied by declining muscle strength in older adults, challenging the notion that low muscle mass is the sole criterion for diagnosing sarcopenia. This review aims to find out the relationships between muscle mass and muscle strength with physical performance in older adults. This article was a systematic review using Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. We do a systematic search of observational studies that are published between 2013 and August 2023 in PubMed, ScienceDirect, Sage journal, Tripdatabase, Cochrane Library, Embase, and CINAHL. Two reviewers selected and extracted data independently and an association measure was recorded from included studies. The review analyzed 17 observational studies conducted between 2013 and September 2023. The findings suggest that while declining muscle mass is often associated with sarcopenia, it may not always correspond to declining muscle strength in older individuals. The most common method used to measure muscle mass was bioelectrical impedance analysis, while handgrip strength was the predominant measure of muscle strength. Tests such as timed up and go and gait speed were used to assess physical performance. Physical performance in older adults is significantly related to muscle strength, whereas the relationship between muscle mass and physical performance is either weak or negligible. Therefore, when evaluating physical performance in older individuals, focusing on muscle strength is more important than muscle mass alone.

Pharmacological Monitoring of Capecitabine in a Gastric Cancer Patient with Hyperbilirubinemia

Objective: To examine therapeutic drug monitoring in managing hyperbilirubinemia caused by capecitabine in patients with gastric adenocarcinoma with extensive liver metastases. Results: The initial liver function tests showed an elevation of transaminases (aspartate amino transferase 615 UI/l, alanine aminotransferase 385.9 UI/l), hyperbilirubinemia (total bilirubin at 246.1 μmol/l), and alkaline phosphatase at 694.6 UI/l. We initiated capecitabine based combination chemotherapy, and the clinical pharmacist conducted a full-course medication monitoring of the patient’s treatment including design of individualized dosing regimens and monitoring of bilirubin, infection, cancer pain, parenteral nutrition support and adverse events. After 21 days of supervision by clinical pharmacist and clinicians, the patient’s bilirubin and transaminase decreased progressively, with aspartate aminotransferase, total bilirubin and alkaline phosphatase falling back to 57 UI/l, 69.8 μmol/l, 307.2 UI/l, respectively. The patient’s condition improved significantly at the time of discharge, with the jaundice subsided, and the bloating relieved. Conclusion: Due to adverse reactions, capecitabine requires medication monitoring during use. The relationship between effectiveness and adverse effects is controversial. Adverse reactions should not be the sole criterion for the use of drugs. Clinical pharmacists can improve the safety and effectiveness of patients’ medications and promote rational drug use by monitoring patients, which may be useful to help the doctors identify the high-risk patients for taking efficient treatment strategy decisions.

Management Practices as a Proxy for Firm Quality

This paper uses firm-level data on management practices to proxy for firm quality. To that end, we create portfolios comprised of well-managed and poorly-managed firms with the management practice score (a number between one and five) as our sole selection criteria. We find that: (1) Between 1999 and 2019, the well-managed portfolio consistently outperformed the poorly-managed portfolio with respect to profitability, investment, default risk, financial strength, and market capitalization; (2) In the period from 1999 to 2008, a portfolio that took a long position in stocks of well-managed firms and a short position in stocks of poorly-managed firms earned a monthly three-factor alpha of 0.89% (t=2.16) and a five-factor alpha of 1.14% (t=2.75).

Fidelity or infidelity?

Abstract This article examines the controversy over The Vegetarian (Han 2015), Deborah Smith’s English translation of Han Kang’s Korean novel, 채식주의자 Chaesikjuuija (2007). The translation, winner of the Man Booker International Prize in 2016, provoked a heated discussion in South Korea. A close analysis of three influential articles – Cho (2017), B. Kim (2017), and W. Kim (2018) – shows how the debates on the supposed mistranslation of The Vegetarian are dominated by a preoccupation with fidelity and literal translation. They dismiss the translator’s interpretation or transformation, regarding accuracy or fidelity as the sole criterion for a good translation. Significantly, the critics’ advocacy of literal translation, and hence their objections to The Vegetarian, reflect three levels of political anxiety: over ‘superior’ translation, over ‘English’ translation, and over a female translator’s ‘feminist’ translation.

Sorting citizens: Governing via China's social credit system

AbstractChina's social credit system can be examined as a governance tool which sorts citizenship behaviors into trustworthy and untrustworthy categories as part of the regime's long‐standing effort to cultivate a loyal citizenry. Based on a data set comprised of central‐level official documents, national model citizen lists, and media reports, this study qualitatively examines how the Chinese state constructs “good” and “bad” citizen ideal types. Contrary to media depictions of the system as digital totalitarianism, political behaviors are not the sole criterion for sorting citizens into categories. In fact, the state constructs “bad” (untrustworthy) citizens as those who engage in a wide range of behaviors, including financial and professional misconduct. Simultaneously, the state also uses the system to construct and cultivate “good” (trustworthy) citizens as those who publicly demonstrate loyalty to the regime. Theoretically, this study sheds light on how the world's most powerful authoritarian regime governs through a system that distributes material and symbolic capital.

Self-interacting superfluid dark matter droplets

ABSTRACT We assume dark matter to be a cosmological self-gravitating Bose–Einstein condensate of non-relativistic ultralight scalar particles with competing gravitational and repulsive contact interactions and investigate the observational implications of such model. The system is unstable to the formation of stationary self-bound structures that minimize the energy functional. These cosmological superfluid droplets, which are the smallest possible gravitationally bound dark matter structures, exhibit a universal mass profile and a corresponding universal rotation curve. Assuming a hierarchical structure formation scenario where granular dark matter haloes grow around these primordial stationary droplets, the model predicts cored haloes with rotation curves that obey a single universal equation in the inner region ($r\, \lesssim \, 1$ kpc). A simultaneous fit to a selection of galaxies from the SPARC data base chosen with the sole criterion of being strongly dark matter dominated even within the innermost region, indicates that the observational data are consistent with the presence of a Bose–Einstein condensate of ultralight scalar particles of mass m ≃ 2.2 × 10−22 eV c−2 and repulsive self-interactions characterized by a scattering length as ≃ 7.8 × 10−77 m. Such small self-interactions have profound consequences on cosmological scales. They induce a natural minimum scale length for the size of dark matter structures that makes all cores similar in length (∼1 kpc) and contributes to lower their central densities.

Four-Parameter Guessing Model and Related Item Response Models

Guessing effects frequently occur in testing data in educational or psychological applications. Different item response models have been proposed to handle guessing effects in dichotomous test items. However, it has been pointed out in the literature that the often employed three-parameter logistic model poses implausible assumptions regarding the guessing process. The four-parameter guessing model has been proposed as an alternative to circumvent these conceptual issues. In this article, the four-parameter guessing model is compared with alternative item response models for handling guessing effects through a simulation study and an empirical example. It turns out that model selection for item response models should be rather based on the AIC than the BIC. However, the RMSD item fit statistic used with typical cutoff values was found to be ineffective in detecting misspecified item response models. Furthermore, sufficiently large sample sizes are required for sufficiently precise item parameter estimation. Moreover, it is argued that the criterion of the statistical model fit should not be the sole criterion of model choice. The item response model used in operational practice should be valid with respect to the meaning of the ability variable and the underlying model assumptions. In this sense, the four-parameter guessing model could be the model of choice in educational large-scale assessment studies.

High Cell Death Rates at Start of Ibrutinib Therapy Predict for Deeper Remissions in Patients with Chronic Lymphocytic Leukemia (CLL)

Introduction: The BTK inhibitor ibrutinib blocks B-cell receptor and other signaling pathways in CLL cells and has become a standard CLL therapy. Isotopic labeling with deuterated water (2H2O) to measure the effects of ibrutinib on CLL cell proliferation and death directly in patients revealed that ibrutinib profoundly inhibits proliferation and induces high rates of leukemia cell death (registered at clinicaltrials.gov as NCT01752426; Burger et al., JCI Insight, 2017). Here, we report a long-term follow-up of this trial in which we analyzed long-term outcomes and correlated CLL cell birth and death rates with depth of response over time. Methods: Thirty patients with previously untreated CLL/SLL enrolled in the study to receive continuous long-term ibrutinib monotherapy, after one month of labeling with deuterated water. For our analyses, we stratified patients in groups based on high or low CLL cell death rates in the peripheral blood (PB) or lymphatic tissues (lymph nodes, spleen), i.e. death rates above or below the median, assessed over the first months on therapy, as detailed in the original publication. Responses were assessed according to 2008 IWCLL guidelines, with the exception that lymphocytosis was not used as a sole criterion for progression. PB MRD was quantified by flow cytometry with a sensitivity 10-4. Results: The median age of the participants was 64 years (range, 48 - 78); 63.3% were male. Thirteen patients (43%) had advanced stage disease, 57% had unmutated IGHV genes, and 10% carried 17p deletion (del17p). Twenty-two patients (73%) completed 5 years of protocol treatment and subsequently continued treatment with commercial supply ibrutinib. The patients were followed for a median time of 107 months (range, 6 - 111). The reasons for eventual treatment discontinuation (n=21) were adverse events (n=8, 38%), progressive disease (n=4, 19%), change to another treatment (n=5, 24%), death (n=2, 7%) and other reasons (n=2, 7%). To date, nine patients are still receiving ibrutinib. Five patients (17%) achieved a complete remission, 24 (80%) achieved partial remission, and one patient (3%) had stable disease, resulting in an overall response rate of 97%. Median progression-free (PFS) and overall survival (OS) were not reached at a median follow-up of 107 months. Five-year PFS was 80.6%, and OS was 90%. PB MRD was measured in 18 patients after 5 years of ibrutinib (54 to 60 cycles); all patients had detectable MRD (median 11.8%, range, 0.06 - 47.30%). We found that CLL cell death rates in PB and tissues after treatment initiation inversely correlated with the level of PB MRD after 5 years (r=-0.5872, P=0.0104 and r=-0.4407, P=0.0672). MRD levels were significantly lower in patients with high CLL cell death rates in PB (7.03% ± 3.68% vs. 29.46% ± 5.53%, mean ± SEM, P=0.0056) and in tissues (9.73% ± 5.49% vs. 28.89% ± 4.42%, P=0.0155) as compared with patients with lower CLL cell death rates (Figure 1). Tissue CLL cell death rates were significantly higher in patients with IGHV-unmutated CLL compared to mutated (28.88% ± 2.75% vs. 13.16% ± 2.82%, P=0.0005), and MRD levels trended lower (IGHV-unmutated: 10.71% ± 5.39% vs. IGHV-mutated: 28.36% ± 6.02%, P=0.0878). No statistically significant correlation was found between CLL cell birth rate at baseline or after start of ibrutinib and MRD levels after 5 years of treatment. Conclusion: CLL cell death rates during early treatment correlated with achieving lower MRD levels. We found that CLL cell death rates are higher in IGHV-unmutated patients suggesting a higher dependency of IGHV-unmutated clones on BCR signaling and, therefore, resulting in deeper responses. Figure 1View largeDownload PPTFigure 1View largeDownload PPT Close modal

Total Tumor Load to assist in the decision for additional axillary surgery in the positive sentinel node breast cancer patients

The Total Tumor Load (TTL) concept has been demonstrated to accurately predict the status of the non-sentinel lymph nodes (NSLN) in breast cancer patients. In 2019, our center implemented the TTL cut-off of 30,000 CK19 mRNA copies/μL as sole criterion for deciding on performing ALND.This retrospective, unicentric, study analyzed 87 cT1-3N0 breast cancer patients treated consecutively in a period of two years and aimed to evaluate the performance of this criterion. Secondary objectives included the comparison of the criterion versus our previous Clinical Decision Rule (CDR) versus ACOSOG Z0011 criteria for avoiding an ALND in proportion of patients spared an ALND and in proportion of patients left with a surgically untreated metastasized axilla. An interim analysis revealed new TTL cut-offs for deciding on performing an ALND.The 30,000 CK19 mRNA copies/μL criterion yielded an area under the ROC Curve (AUC) of 0.849, a false positive (FP) rate of 30.1% and a positive predictive value (PPV) of 38.9%. The 30,000 CK19 mRNA copies/μL criterion spared 58.6% of the patients an ALND versus 41.4% with CDR versus 73.6% with Z0011 and left 0.0% patients with a surgically untreated metastasized axilla versus 21.4% with CDR versus 42.9% with Z0011. The new TTL cut-off of 260,000 CK19 mRNA copies/μL for deciding on an ALND yielded an AUC of 0.753, a FP rate of 13.7% and a PPV of 47.4%. This new criterion spared 78.2% of the study sample an ALND and left 35.7% of metastasized axillae surgically untreated.This study emphasizes the need to find a new balance between locoregional control and the morbidity associated with Berg levels I + II axillary lymph node dissection.

Beyond Slavery's Shadow: Free People of Color in the South by Warren Eugene Milteer Jr.

Reviewed by: Beyond Slavery's Shadow: Free People of Color in the South by Warren Eugene Milteer Jr. Scarlet Jernigan Beyond Slavery's Shadow: Free People of Color in the South. By Warren Eugene Milteer Jr. (Chapel Hill: University of North Carolina Press, 2021. Pp. [xii], 363. Paper, $29.95, ISBN 978-1-4696-6439-2; cloth, $95.00, ISBN 978-1-4696-6438-5.) In Beyond Slavery's Shadow: Free People of Color in the South, Warren Eugene Milteer Jr. expands on his book North Carolina's Free People of [End Page 772] Color, 1715–1885 (Baton Rouge, 2020) to provide a needed overview of the "collective lives of free people of color" in the South (p. 11). He rejects older scholarship by Ira Berlin and others who asserted that free persons of color were "'slaves without masters'" who existed between "'abject slavery'" and "'full freedom'" (p. 11). Instead, Milteer contends that free people of color "experienced a freedom that was contested yet worth defending" (p. 12). "Intersecting social hierarchies" of "wealth, gender, occupation, reputation, and religion" resulted in diverse behaviors among free persons of color and a "complex assortment of relations" with white southerners (pp. 2, 4). Seven chapters and a conclusion span from the colonial era to Reconstruction. In chapters 1 and 2, the author compares the lives of free people of color in the colonial South with their counterparts in other empires, noting discrimination along with diversity, complexity, and flexibility. During the American Revolution, "unsettled social landscapes" led to either opportunity or oppression (p. 52). In chapters 3 and 4, Milteer examines the next forty-some years, as white people "struggled to determine the proper place for free people of color" (p. 69). Despite "unprecedented attacks," free persons of color and their allies tempered the success of those who sought to make race the sole criterion to determine status (p. 71). Cross-racial bonds of kinship, community, worship, and business held, and free people of color "found ways to convey their societal importance" (p. 116). They founded separate organizations when "working with whites as equals was not possible or desirable" (p. 122). Chapters 5 and 6 begin with the Nat Turner rebellion, which allowed progressively more radical proslavery whites to push free people of color into an "increasingly inferior legal status" (p. 184). Yet the rebellion did not result in a "revolutionary change in the ways average white southerners thought about" free persons of color (p. 138). In the decades leading up to the Civil War, free people of color could still "find justice in a system not designed for their benefit" as they actively defended their rights (p. 180). In chapter 7's examination of the Civil War, Milteer shows that free persons of color pursued divergent paths based on their complex and layered identities. Utilizing county court minutes, apprenticeship bonds, state legislative records, wills, newspapers, and pension files, Milteer focuses on the realities of day-to-day life instead of the contents of legal codes or extremist rhetoric. He cites Melvin Patrick Ely's Israel on the Appomattox: A Southern Experiment in Black Freedom from the 1790s Through the Civil War (New York, 2005) as an important precursor to his work. Milteer characterizes white southern behavior toward free people of color as "fluid," contradictory, and far from monolithic (p. 5). Free persons of color were vital to society and the economy, and radicals sought—unsuccessfully—to push them to the margins. Milteer concludes that many "find understanding the South before 1865 much easier if we can simplify the social hierarchy," but he argues that doing so offers a skewed picture of reality (p. 254). The author skillfully reveals the sometimes-intersecting values of whites and free people of color, as well as "inconsistencies between the law and everyday behavior," and then provides a framework for understanding them (p. 255). [End Page 773] Scarlet Jernigan Piedmont University Copyright © 2022 The Southern Historical Association

Comparative Analysis of Electric Field Strength, Magnetic Field Strength and Power Density around the Cell Phone Towers of Varying Characteristics with a Proposed Classification Facilitating Research on Human Population.

The continuous exposure of electromagnetic field (EMF) radiation from cell phone towers may possibly have an influence on public health. Each cell phone tower is unique in terms of number of antennas and its associated attributes; thus, the radiation exposure varies from one tower to another. Hence, a standardized method for quantifying the exposure is beneficial while studying the effects of radiation on the human population residing around the cell phone towers. A mere collection of data or human samples without understanding the cell phone tower differences may show study results such as an increase or decrease in biological parameters. Those changes may not be due to the effects of EMF radiation from cell phone towers but could be due to any other cause. Therefore, a comparative study was designed with the aim of quantifying and comparing the electric field strength (EF), magnetic field strength (MF) and power density (PD) on four sides of cell phone towers with varying numbers of antennas at 50 m and 100 m. Further, an attempt was made to develop a PD-based classification for facilitating research involving human biological samples. Through convenience sampling, sixteen cell phone towers were selected. With the use of coordinates, the geographic mapping of selected towers was performed to measure the distance between the towers. Based on the number of antennas, the cell phone towers were categorized into four groups which are described as group I with 1-5 antennas, group II comprising of 6-10 antennas, group III consisting of 11-15 antennas and group IV comprised of towers clustered with more than 15 antennas. The study parameters, namely the EF, MF and PD, were recorded on all four sides of the cell phone towers at 50 m and 100 m. One-way ANOVA was performed to compare the study parameters among study groups and different sides using the Statistical Package for the Social Sciences (SPSS) version 25.0. The mean MF in Group IV was 2221.288 ± 884.885 μA/m and 1616.913 ± 745.039 μA/m at 50 m and 100 m respectively. The mean PD in Group IV at 50 m was 0.129 ± 0.094 μW/cm2 and 0.072 ± 0.061 μW/cm2 at 100 m. There was a statistically significant (p < 0.05) increase in the MF and PD at 50 m compared to 100 m among cell phone tower clusters with more than 15 antennas (Group IV). On the other hand, a non-significant increase in EF was observed at 50 m compared to 100 m in Group II and IV. The EF, MF and PD on all four sides around cell phone towers are not consistent with distance at 50 m and 100 m due to variation in the number of antennas. Accordingly, a PD-based classification was developed as low, medium and high for conducting research involving any biological sample based on quantile. The low PD corresponds to 0.001-0.029, medium to 0.03-0.099 and high to 0.1-0.355 (μW/cm2). The PD-based classification is a preferred method over the sole criteria of distance for conducting human research as it measures the true effects of EMF radiation from the cell phone towers.

Microbiome-driven breeding strategy potentially improves beef fatty acid profile benefiting human health and reduces methane emissions

BackgroundHealthier ruminant products can be achieved by adequate manipulation of the rumen microbiota to increase the flux of beneficial fatty acids reaching host tissues. Genomic selection to modify the microbiome function provides a permanent and accumulative solution, which may have also favourable consequences in other traits of interest (e.g. methane emissions). Possibly due to a lack of data, this strategy has never been explored.ResultsThis study provides a comprehensive identification of ruminal microbial mechanisms under host genomic influence that directly or indirectly affect the content of unsaturated fatty acids in beef associated with human dietary health benefits C18:3n-3, C20:5n-3, C22:5n-3, C22:6n-3 or cis-9, trans-11 C18:2 and trans-11 C18:1 in relation to hypercholesterolemic saturated fatty acids C12:0, C14:0 and C16:0, referred to as N3 and CLA indices. We first identified that ~27.6% (1002/3633) of the functional core additive log-ratio transformed microbial gene abundances (alr-MG) in the rumen were at least moderately host-genomically influenced (HGFC). Of these, 372 alr-MG were host-genomically correlated with the N3 index (n=290), CLA index (n=66) or with both (n=16), indicating that the HGFC influence on beef fatty acid composition is much more complex than the direct regulation of microbial lipolysis and biohydrogenation of dietary lipids and that N3 index variation is more strongly subjected to variations in the HGFC than CLA. Of these 372 alr-MG, 110 were correlated with the N3 and/or CLA index in the same direction, suggesting the opportunity for enhancement of both indices simultaneously through a microbiome-driven breeding strategy. These microbial genes were involved in microbial protein synthesis (aroF and serA), carbohydrate metabolism and transport (galT, msmX), lipopolysaccharide biosynthesis (kdsA, lpxD, lpxB), or flagellar synthesis (flgB, fliN) in certain genera within the Proteobacteria phyla (e.g. Serratia, Aeromonas). A microbiome-driven breeding strategy based on these microbial mechanisms as sole information criteria resulted in a positive selection response for both indices (1.36±0.24 and 0.79±0.21 sd of N3 and CLA indices, at 2.06 selection intensity). When evaluating the impact of our microbiome-driven breeding strategy to increase N3 and CLA indices on the environmental trait methane emissions (g/kg of dry matter intake), we obtained a correlated mitigation response of −0.41±0.12 sd.ConclusionThis research provides insight on the possibility of using the ruminal functional microbiome as information for host genomic selection, which could simultaneously improve several microbiome-driven traits of interest, in this study exemplified with meat quality traits and methane emissions.6mp-1d5cpTQY_WdEUFHrBcVideo

The interplay of acceptance and effectiveness in intervention studies: the example of the empCARE training to reduce burnout and distress symptoms in health care providers

Objective Although almost every study evaluating psychological interventions includes the two components of acceptability and effectivity, their relationship is rarely examined. The current study closes this gap by performing secondary analyses of the intervention program ‘empCARE’. The goal was to analyze the relationship between these two evaluation components. Design The sample consists of 309 nurses (intervention group n = 172; control group n = 137). Data were collected before the training and longitudinally three times after the training. Main Outcome Measures Psychological distress was assessed using the Symptom Checklist (SCL-90-R), and the Copenhagen Burnout Inventory. Personality traits were assessed using the HEXACO-60 and the Toronto Empathy Questionnaire. Acceptability was assessed using statements concerning participants’ subjective evaluation of the training. Results The results show that the intervention program was effective. Acceptability, measured only in the intervention group, was quite high. However, no connection was found between effectivity and acceptability. On the contrary, the results show that acceptability assessments depend more on personality factors than on intervention success. Conclusions Researchers should examine the relationship between acceptability and effectivity in their data. It does not seem appropriate to rely on acceptability measurements as the sole evaluation criterion capturing the success of an intervention.

P397 Influence of underlying conditions on disease presentation and diagnostic strategy during pulmonary mucormycosis: Anational study of 114 cases

Poster session 3, September 23, 2022, 12:30 PM - 1:30 PM ObjectivesPulmonary mucormycosis (PM) is a life-threatening invasive fungal infection mostly affecting immunocompromised patients. We aimed to study the influence of underlying conditions on disease presentation and diagnostic strategy during PM.MethodsAll PM cases from six French teaching hospitals between 2008 and 2019 were retrospectively reviewed. Cases were defined according to EORTC/MSG 2019 criteria with the addition of diabetes and traumatism as host factors and positive serum or tissue PCR as mycological evidence. Thoracic CT scans were reviewed centrally.ResultsAmong 114 cases of PM, 52 (46%) were proven and 62 (54%) were probable, including 12 cases with a positive serum qPCR as the sole mycological criterion. Hematological malignancy was the most common risk factor (49%), followed by allogeneic hematopoietic stem-cell transplantation (21%), and solid organ transplantation (SOT, 17%). Fever was the first symptom for 66% patients and was more frequent in patients with neutropenia than in those without (97% vs 52%, P <.01). A total of 46 (40%) patients had a disseminated infection, which was more frequently reported in neutropenic patients (50% vs 25%, P <.01). Main dissemination sites were the liver (48%), spleen (48%), brain (44%), and kidneys (37%). Sinusitis was present in 13% of cases.Chest radiological presentation included consolidation (58%), pleural effusion (52%), reversed halo sign (26%), halo sign (24%), vascular abnormalities (26%), and excavation (23%). The excavation was more frequently reported in SOT patients (64%, P <.01) compared with other groups. Vascular involvement was associated with reversed halo sign and Rhizomucor infection. Neutropenic patients presented more frequently than non-neutropenic patients with ground-glass opacities (75 vs 49%, P = .01), halo sign (32% vs 10%, P = .02), and reversed halo sign (35 vs 10%, P <.01).A total of 83 (73%) patients had a positive fungal culture from any type of respiratory sample. Serum qPCR was positive for 42/53 patients (79%) and respiratory fluid qPCR for 16/21 (76%) patients. In neutropenic patients, BAL culture was less often positive (30% vs 66%, P <.01), and serum qPCR was more frequently positive (91% vs 62%, P = .02). A transthoracic lung biopsy was contributive in 8/11 (73%) patients with negative bronchoalveolar lavage (BAL). Serum qPCR was more frequently positive in patients with the main lesion of >3 cm in diameter (91% vs 62%, P = .02). Rhizomucor spp. Was identified in 31 patients (32%), Rhizopus spp. In 29 patients (30%), Lichtheimia spp. In 24 patients (25%), Mucor spp. In 10 patients (10%) and Cunninghamella spp. In 4 patients (4%). Neutropenic patients were more frequently infected with Rhizomucor (43% vs 13%, P <.01) and less frequently with Rhizopus (17% vs 50%, P <.01). Histopathological specimens were available for 48 patients (42%) and revealed Mucorales hyphae in 85% of cases. Patients with a disseminated infection and neutropenia presented more often with angioinvasion than patients with localized disease (50% vs 9%, P <.01 and 38% vs 13%, P = .10). Overall, 90-day mortality was 59%.ConclusionUnderlying conditions significantly influenced clinical and radiological presentation and diagnostic tools’ contribution. Neutropenic patients present more frequently with dissemination, fever, reversed halo sign, pathological angioinvasion, the negativity of BAL culture, the positivity of serum qPCR, and Rhizomucor infection.

Effectiveness and costs of a new framework for selecting absorbent urinary incontinence products compared with current practice: a cohort study

ObjectivesTo improve continence care in the Netherlands, a new framework has been developed in which a shift has been made from incontinence severity as the sole criterion for selecting incontinence...

The Effect of Manipulating Task Complexity Along Resource-Dispersing Dimension on L2 Written Performance from the Perspective of Complexity Theory

From the perspective of complexity theory and based on Robinson&amp;#39;s Cognition Hypothesis and the Triadic Componential Framework, this paper investigated the effect of manipulating task complexity along resource-dispersing dimension on L2 written performance. The results showed that: 1) Significant interactive effects were found between the two variables (i.e. task structure and planning). 2) Without planning, the accuracy and fluency of written output in tasks without structural constraint were significantly higher, while the syntactic complexity was lower. 3) Planning had no significant effect on accuracy. In macro-structure given task, planning promoted fluency and lexical complexity, but did not affect syntactic complexity. The result only partially supports the Cognition Hypothesis. Combined with previous research, it can be found that written output in tasks is nonlinear, multidimensional and self-adaptive. Researchers and teachers are suggested to fully consider task characteristics and individual differences, and not to take task complexity as the sole criterion when designing writing tasks.&amp;nbsp;&#x0D; &amp;nbsp;