Knowledge of the soil wetting pattern characteristics of vertical moistube-irrigation is essential for the design of cost-effective and efficient irrigation systems. We conducted laboratory experiments to determine the specific discharge calculation formula and compare the accuracy of HYDRUS-2D simulation. The cumulative infiltrations, wetting pattern distances, and water content distributions predicted with HYDRUS-2D were found to align well with experimental data. The results provide support for using HYDRUS-2D as a tool for investigating and designing moistube-irrigation management practices. Numerical simulations were carried out with HYDRUS-2D to investigate the influence of soil texture, initial water content, pressure head, moistube length, and buried depth on wetting pattern characteristics. There are small differences in the shape of the soil wetting pattern, as well as significant differences in size. The wetting pattern and water content contour are approximately “ellipsoid” around the moistube. Soil texture has a significant effect on the wetting pattern characteristics, the vertical and horizontal wetting front distance, and the wetted soil volume decrease along with the increase of soil clay content. The initial water content, pressure head, and moistube length have great influence on the wetting front distance and the wetted soil volume. Both are positively correlated with the initial water content, pressure head, and length. Moistube buried depth affects the wetting pattern position. The soil wetting pattern decreases synchronously as the buried depth drops.