Objective: The aim of this study was to evaluate the plaque removal efficacy of soft bristles toothbrushes (SBTB) compared with medium bristles toothbrushes (MBTB) using clinical periodontal parameters in orthodontic patients with self-ligating brackets. Methods: A total of 32 orthodontic patients scheduled for fixed orthodontic treatment were selected for this prospective study. Patients were divided into randomly two groups brushing with tooth brusher type as follow SBTB and MBTB. The bonded bracket plaque index (PI), and pocket depth values (PDV) were evaluated 1 week after bracket placement (T1), 2 weeks after bracket placement (T2); and 3 weeks after bracket placement (T3). The Friedman and Mann Whitney U tests were used to analyze the data. Results: There was no statistically significant difference between the groups regarding PI and PDV values (p > 0.05). In the MBTB group, PDV values revealed statistically significant changes between T2 and T3 (p 0.05). MBTB grubunda, PDV değerleri T2 ve T3 tedavi zamanları arasında istatistiksel olarak anlamlı değişiklik göstermiştir (P <0.05). Ayrıca, ağrı skorları gruplar arasında bir hafta sonunda anlamlı farklılık göstermemiştir (P = 0.540). Sonuç: Yumuşak kıl formasyonuna sahip diş fırçası ile orta sertlikte kıl formasyonuna sahip diş fırçası tiplerinin kapaklı braket kullanılan ortodonti hastalarında periodontal parametreler açısından bir farklılığa sebep olmamıştır