Soft Tissue Chondroma Research Articles

Soft tissue chondroma with t(3;12)(q27;q15)

Review on Soft tissue chondroma with t(3;12)(q27;q15), with data on clinics, and the genes involved.

Sinovite vilonodular pigmentada localizada: relato de caso

O caso em questão é o de uma paciente do sexo feminino que apresentava queixa de dor na região anterior do joelho esquerdo durante e após atividades esportivas, seguidas de bloqueio articular havia três meses. Exames de imagem: radiografias simples do joelho normais e ressonância magnética mostrando formação expansiva sólida podendo corresponder a condroma de partes moles ou a sinovite nodular focal. Realizada ressecção artroscópica da lesão com diagnóstico de tumor de células gigantes difuso símile/sinovite vilonodular pigmentada localizada (SVNPL) após resultado do exame anatomopatológico. A paciente apresenta boa evolução clínica com desaparecimento dos sintomas e retorno às atividades físicas.

Subungual Tumors: Clinicopathologic Correlation with US and MR Imaging Findings

Various types of tumors can affect the subungual space, including benign solid tumors (glomus tumor, subungual exostosis, soft-tissue chondroma, keratoacanthoma, hemangioma, lobular capillary hemangioma), benign cystic lesions (epidermal and mucoid cysts), and malignant tumors (squamous cell carcinoma, malignant melanoma). Imaging plays an important role in the detection and differentiation of subungual tumors because of their small size, nonspecific clinical manifestations, and functional significance. Ultrasonography (US)-in particular, high-resolution US with color Doppler studies-provides useful information regarding tumor size, location, shape, and internal characteristics (cystic, solid, or mixed), but it is limited in the further characterization of tissue. Magnetic resonance (MR) imaging has an important role in categorizing tumors according to their anatomic location, pathologic origin, and signal characteristics. There is some overlap between the US and MR imaging features of subungual tumors; however, certain features can allow accurate diagnosis and expedite management when correlated with clinical and pathologic findings.

Extraskeletal soft tissue chondroma of the cheek

Extraskeletal soft tissue chondroma is a rare, benign, slow-growing cartilaginous tumor. Its pathological diagnosis is based on radiological and histopathological examination. There are a few reports of soft tissue chondroma in this region. We present a 57-year-old man with a painless mass measuring \( {6}.{7} \times {6}.0 \times {4}.0{\hbox{cm}} \) in the left cheek.

Arthroscopic Resection of the Chondroma in the Supraspinatus of the Shoulder

Soft-tissue chondroma is rare a benign soft-tissue tumor that occurs mainly in hands and feet. There have been no reports of a chondroma in the supraspinatus tendon. We describe the clinical, histological and radiological features of the intratendinous chondroma of the supraspinatus occurring in a 30-year-old man who was managed arthroscopically and a review of the relevant literature review.

Concurrent Soft Tissue Chondroma and Periosteal Chondroma of Thumb

Chondromas are classified according to their locations as enchondroma, periosteal chondroma, and the extraskeletal soft tissue chondroma. Multiple chondromas are well known as part of some disease entities like enchondromatoses and synovial chondromatosis. Many authors reported multiple chondromas previously; however, we have not encountered any instance of coexistence of soft tissue and periosteal chondromas in the English literature. We present a case with concurrent soft tissue and periosteal chondromas appeared five years after hand trauma with clinical, radiological and histological features.

Extraskeletal chondroma of the masseter muscle: a case report with review of the literature

The authors report a case of soft tissue chondroma of the masseter muscle in a 49-year-old man. The tumour was entirely composed of lobules of hyaline cartilage. The literature on head and neck soft tissue chondroma is also reviewed. To the authors' knowledge, this is the first case of muscular soft tissue chondroma in the head and neck region.

Cartilage Choristoma (Soft Tissue Chondroma): A Rare Presentation in the Lower Lip

Cartilage choristoma (soft tissue chondroma) is an ectopic cartilaginous tissue that is rarely found in oral mucosa. Awareness of such disease entity will guide proper diagnosis and treatment. A case of cartilage choristoma occurring in the lower lip of an 8-year-old child is reported. Potential pathogenetic mechanism and the histologic features of this unusual condition are further discussed.

A Soft Tissue Chondroma Originating from the Dura Mater of the Lumbar Spinal Canal and it Mimicked a Nerve Sheath Tumor: A Case Report with the MR Imaging

Soft tissue chondromas are the benign chondro-osseous tumors of soft tissue that usually occur in the extra-osseous and extra-synovial regions of the extremities. We present here a rare location for a soft tissue chondroma that originated from the dura mater in the lumbar spinal canal, and it mimicked a nerve sheath tumor. We present here the MRI findings and pathologic features of this tumor.

Diffuse mineralization of forearm extraskeletal chondroma

We report on the clinical, histologic, and radiologic features – including CT and MRI – of extraskeletal chondroma in a rare case of diffuse calcification of the chondroid matrix. T2-weighted MR imaging showed a well-demarcated mass of low signal intensity in the left flexor digitalis profundus, with a slight surrounding intramuscular edema. Histopathological examination revealed a heavily calcified soft-tissue chondroma generating macrophagic foreign body reaction. Knowledge of this unusual pattern of mineralization may help in the radiological diagnosis of extraskeletal chondroma.

Fibrosis and Adventitious Bursae in Plantar Fat Pad of Forefoot: MR Imaging Findings in Asymptomatic Volunteers and MR Imaging–Histologic Comparison

To retrospectively evaluate plantar fat pad (PFP) signal intensity alterations in magnetic resonance (MR) imaging studies of asymptomatic volunteers and to compare PFP alterations with histopathologic findings in cadavers and patients. After appropriate institutional review board approval and any required informed consent were obtained, MR imaging studies of 70 asymptomatic volunteers (35 women, 35 men; mean age, 45 years; range, 21-69 years) obtained for another investigation were retrospectively analyzed by two musculoskeletal radiologists in consensus. The location, signal intensity, margin, extent, and size of PFP alterations were determined. MR imaging-histopathologic comparison was performed in six cadaveric feet and six feet of symptomatic patients (one woman, five men; mean age, 43 years; range, 31-60 years). For volunteers, the relationship between PFP alterations and Morton neuroma, age, and sex was analyzed by using the Fisher exact test, Spearman rank correlation, and the Wilcoxon rank sum test, respectively. Bonferroni correction was applied, and P < .01 was considered to indicate a significant difference. Fifty-nine (84%) volunteers had PFP signal intensity alterations. Forty-nine (70%), six (9%), one (1%), four (6%), and 43 (61%) volunteers had alterations beneath the first, second, third, fourth, and fifth metatarsal heads, respectively. Ninety-four (91%) of 103 signal intensity alterations were in the form of hypointensity on T2-weighted images. Blurred margins were present in 90 (87%) alterations. Ninety percent of all PFP alterations in asymptomatic volunteers were 14 mm or smaller. The relationship between PFP alterations and Morton neuroma, age, and sex was not statistically significant. In cadaveric forefeet, PFP alterations corresponded histopathologically to a variable amount of fibrosis. In nine PFP alterations, development of fluid-containing spaces resembling bursae was present. Among the six patients with PFP alterations, histopathologic examination revealed fibrosis and adventitious bursae in two, fibrosis with inflammation in three, and a soft-tissue chondroma in one. PFP signal intensity alterations are commonly seen in asymptomatic volunteers under the first and fifth metatarsal heads. At histologic examination, PFP signal intensity alterations correspond most commonly to fibrosis and adventitious bursae.

Lateral views and subungual soft-tissue chondromas

Lateral views and subungual soft-tissue chondromas

Multiple Ipsilateral Lower Extremity Masses in a 46-year-old Man

Multiple Ipsilateral Lower Extremity Masses in a 46-year-old Man

Soft-tissue chondroma.

Soft-tissue chondromas are rare and benign soft-tissue tumors. Over 95% occur in the hands and feet. They are seen in both sexes equally and mainly occur in patients aged 30-60 years. If excised fully, they do not reoccur, and no cases in the literature have reported malignant transformations.

Soft tissue chondroma compression—A unique cause of tarsal tunnel syndrome: A case report and review of the literature

Posterior tibial nerve entrapment can be caused by extrinsic compression in the tarsal tunnel. We report a nerve compression due to a chondroma in the tarsal tunnel. To our knowledge it is a very rare cause of tarsal tunnel syndrome.

A Soft Tissue Chondroma Presenting As A Rapidly Enlarging Mass Within The Hand With Associated Median Nerve Compression

We present the case of a rapidly enlarging mass in the hand which was removed at surgery with comparative ease and confirmed to be a soft tissue chondroma.

Soft-tissue chondroma of the masticatory space

Soft-tissue chondroma is an infrequent, benign, cartilaginous tumour that is uncommon in the head and neck region. Single-location chondromas rarely evolve into malignant neoplasms. Chondromas are composed of hyaline cartilage with focal calcification. There have been a few reports published of cases of soft-tissue chondroma of the neck and parapharyngeal space. Here is described a new location of this tumour in the masticatory space.

Imaging and pathological correlation of soft-tissue chondroma: A serial five-case study and literature review

The imaging findings (X-ray and MRI) and patterns of calcification of five patients with pathologically proven soft-tissue chondroma were correlated with histopathology. The size ranged from 0.5 to 3 cm. Four showed calcifications: curvilinear, punctuate, mixed curvilinear, and punctuate patterns, and the other one with a dystrophic or homogenous dense pattern showed hypointensity on T1- and T2-weighted MR imaging. Histopathology showed hyaline cartilage with nests of chondrocytes in the lacunae. Soft-tissue chondroma is a rare, benign soft-tissue tumor. It should be differentiated from other soft-tissue masses, especially malignancy.

Fusion of the HMGA2 and NFIB genes in lipoma

The major cytogenetic subgroup of lipomas is characterized by aberrations of chromosome segment 12q13-15, which recombines with a large number of other chromosomal regions. The gene HMGA2 is the main target in these aberrations. For some recurrent rearrangements, chimeric transcripts, including the 5' part of HMGA2, have been described. The 3' partners identified are LPP, LHFP, CMKOR1, and EBF. In addition, subsets of other benign solid tumors show aberrations of 12q13-15. Among pleomorphic adenomas of the salivary glands, where the preferred recombination partner with 12q13-15 is 9p22-24, an HMGA2/NFIB fusion gene has been reported. In the present study, two cases of lipoma with rearrangements of 9p22-24 and 12q15 were analyzed by reverse transcription polymerase chain reaction to find out if HMGA2/NFIB was also present in lipoma. An in-frame fusion transcript, combining the four first exons of HMGA2 with exon 8 of NFIB, was detected in one case. It was identical to a transcript that was previously described in salivary gland adenoma and contained a stop codon shortly 3' of the fusion point. The finding of the same fusion gene in different tumors is not unique. For example, HMGA2/LPP has been reported in lipoma, pulmonary chondroid hamartoma, and soft tissue chondroma. Since similar 9;12 translocations have been described also in rare cases of hamartoma and uterine leiomyoma, the occurrence of HMGA2/NFIB could be postulated in these tumors as well.

MR Imaging of the Forefoot: Morton Neuroma and Differential Diagnoses

Magnetic resonance (MR) imaging of Morton neuromas is highly accurate. Morton neuromas are more conspicuous when the patient is prone positioned and the foot is plantar flexed than in the supine position with the toes pointing upward. MR imaging of Morton neuromas has a large influence on the diagnostic thinking and treatment plan of orthopedic foot surgeons. The most common differential diagnoses include intermetatarsal bursitis, stress fractures, and stress reactions. Some diagnoses (nodules associated with rheumatoid arthritis, synovial cyst, soft tissue chondroma, and plantar fibromatosis) are rare and can be diagnosed with histologic correlation only.