Abstract Purpose: To evaluate the effect of incorporating three nanoparticles (Titanium oxide, silicon oxide, and alumina) with 1% and 5% concentration on the bond strength to denture base for one year of clinical service. Methods: Fifty-six completely edentulous patients were selected and divided into seven groups according to the nanoparticle material and concentration (n=7). Upper and lower complete dentures were fabricated for each patient. The adhesion of soft liner was done using a five scale questionnaire at insertion (baseline) 4, 8, and 12 months of denture insertion. The data were analyzed by Friedman test with post-hoc Dunn test. Results: At 4 and 8 months, all the nanoparticles groups showed a non-statistically significant difference from the baseline. At 12 months, all groups with 5% nanoparticle concentration showed a statistically significant decrease in the soft liner adhesion. The same insignificance was found between the control and the baseline. And in-between all of the groups of the nanoparticles during all of the follow-up intervals. Conclusion: The addition of nanoparticles to the denture base effectively improved the bond between the soft-liner and the denture base, especially for concentrations below 5%.