Objectives: Sexually transmitted infections (STIs) are a significant public health challenge in India. Limited healthcare access, socioeconomic inequalities, and gender-based vulnerabilities contribute to the disproportionate burden in rural and urban areas. The aim of this study was to compare the sociodemographic profile, sexual behavior, and the syndromic diagnosis of STIs between rural and urban cases attending an STI clinic. Materials and Methods: A cross-sectional retrospective study was conducted at an STI clinic in east-central region of India. All patients, irrespective of age and sex, who visited the clinic from July 2022 to November 2023, were included in the study. Demographic, clinical, and behavioral data were compared between urban and rural cases using appropriate statistical methods. Results: Out of 925 patients, rural and urban cases were 70.8% and 29.2%, respectively. Rural cases: 92.2% females, 7.8% male; urban cases: 81.1% females, 18.9% males. The majority were aged 20 -40 years. There were more cases aged below 20 years from urban areas (6.3% vs. 2.7%; P < 0.01). Illiterate cases were more from rural area (P < 0.01); and those educated >10th grade from urban area (P < 0.01). The predominant occupation was homemakers and incomes ranged between Rs 5000 and 10000. In both rural and urban areas, lower abdomen pain was the most common symptom, followed by vaginal discharge. Genital herpes (P < 0.01) and syphilitic genital ulcers to syphilis (P = 0.01) were more common in urban areas compared to rural. Retroviral infection was reported to be similar from both areas.: Mean age of sexual debut was 19.5 years in rural and 20.2 year in cases from urban areas (P < 0.01). Time since last sexual encounter (21.2 vs. 20.3 days, P = 0.01), and cases with multiple partners (4.1% vs. 8.8%; P < 0.01) were different in cases from rural and urban cases. The difference in drug abuse and contact with sex worker were not significantly different between the groups. Limitations: Retrospective study design, hospital-based study setting and lack of microbiological confirmation were the limitations of this study. Conclusion: There were disparities in the sociodemographic profile, STI patterns, and sexual behavior between rural and urban cases of the east-central zone of India.
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