Social Behavior Research Articles

Technology-Based Interventions for Autism Spectrum Disorder: A Systematic Review

Introduction: Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by deficits in social communication and repetitive behaviors. Its prevalence has steadily increased, with the CDC reporting a rise from 1 in 100 children in 2006 to 1 in 44 in the United States by 2021. ASD manifests in a spectrum of symptoms, requiring tailored interventions to address each child's unique needs. Recent advancements in technology have shown promise in aiding children with ASD, particularly through robotics and socially assistive robots (SARs). This systematic review explores the impact of technology-based interventions on children with ASD, assessing their efficacy in enhancing social skills, communication, and behavior regulation. Methodology: This review followed PRISMA guidelines, screening 46,580 articles across databases such as PubMed, Cochrane, Science Direct, Google Scholar, and PsychInfo. After applying inclusion and exclusion criteria, 254 studies were selected for in-depth review. The review focused on technology-based interventions, including robotics and socially assistive robots, with MeSH terms such as "Technology," "Artificial Intelligence," "Autism Spectrum Disorder," and "ASD." Results: Technology-based interventions, particularly SARs, demonstrated significant improvements in social interaction, emotional regulation, and communication for children with ASD. Robots such as LEGO Mindstorms and "Kaspar" were effective in enhancing eye contact, cooperation, and emotional recognition. However, results varied depending on the type of technology used, study design, and participant characteristics. Conclusion: While technology-based interventions hold promise for children with ASD, further research is needed to standardize intervention protocols, dosage, and long-term outcomes. These tools offer a non-invasive, scalable solution for enhancing social and cognitive skills, but variability in study designs limits definitive conclusions. Keywords: Autism Spectrum Disorder, Technology, Robotics, Socially Assistive Robots, Communication, Cognitive Skills, Applied Behavioral Analysis

Post-traumatic stress disorder and metabolic syndrome: the role of some antioxidants in treatment

The basis for the pathogenesis of cardiovascular, cancer, metabolic diseases, low-grade chronic inflammation (LGCI) and many other disorders is an imbalance between prooxidants and the antioxidant defense system. It is believed that the link between post-traumatic stress disorder (PTSD) and metabolic syndrome (MetS) is based on oxidative stress (OS), increased autonomic nervous system activity, glucocorticoid synthesis activation, or immunological dysregulation. Moreover, pathophysiological changes in the systemic LGCI pathways that result from modifications in glucocorticoid receptor reactivity (secondary to emotional and physiological arousal) may be the basis for inappropriate social behavior consistent with PTSD and MetS manifestations. Recently, evidence has emerged suggesting that a combination of high levels of systemic OS and activation of LGCI plays an important role in the pathogenesis of PTSD. On the other hand, PTSD is a type of recurrent and long-term trauma that exacerbates OS and accele­rates cellular aging. LGCI is accompanied by the release of reactive oxygen and nitrogen species, proinflammatory cytokines, and other biologically active substances that cause OS. The purpose of this review was to discuss the role of individual antioxidants, in particular polyphenols, flavonoids, carotenoids, N-acetylcysteine, melatonin, L-arginine, C and E vitamins, zinc, copper, and selenium, in the prevention/treatment of comorbid pathology of PTSD and MetS, as well as to analyze new trends and directions for future research. The search was conducted in Scopus, Science Direct (from Else­vier) and PubMed, including MEDLINE databases. The keywords used were “post-traumatic stress disorder,” “metabolic syndrome,” and “antioxidants.” To identify research results that could not be found during the online search, a manual search of the bibliography of publications was used.

Social health, activity behaviors, and quality of life among young adult cancer survivors: Protocol for a prospective observational study.

Approximately 85,000 adolescent and young adults (AYAs; age 15-39) are diagnosed with cancer in the United States annually. Experiencing a cancer diagnosis as an AYA can substantially impact social connections and social health. This paper describes the design and protocol of an observational study to prospectively assess social health and its association with physical activity and quality of life among AYAs after a cancer diagnosis. The study uses a longitudinal observational design to prospectively explore the relationships between social health and activity behaviors (physical activity and sedentary time) at four clinically significant timepoints over the course of 12 months among AYAs newly diagnosed with cancer. Patients are recruited at three hospitals and surveyed at each time period. Multiple dimensions of social health are assessed including social support, social roles, loneliness, social anxiety, and social networks. A wrist accelerometer is worn for one week at each assessment period. Change in social network structures will be analyzed using egocentric social network analysis. Structural equation models will be fitted to analyze the relationship between social constructs and physical activity. Findings from this study will address gaps in our understanding of the impact of a cancer diagnosis on multiple dimensions of social health for AYAs and the potential role social factors play in physical activity and quality of life. Understanding these processes will inform age-tailored interventions to improve health and quality of life outcomes for this at-risk population.

A study of police personnel wellbeing in England and Wales whilst working during the Covid-19 pandemic

ABSTRACT This paper presents the findings of a mixed-method study exploring the self-reported negative impact on wellbeing of working in policing in England and Wales during the Covid-19 pandemic. For the first time, findings relating to the wellbeing of UK police and police staff are presented from two different points in time during the pandemic period – the initial ‘lockdown phase’ (March 2020) and Autumn 2021 as the UK began to return to pre-pandemic social behaviours. A first study presents data collected via electronic survey, completed in June 2021 by more than 500 UK police officers and staff, exploring how they felt initially about the Covid-19 pandemic and how they felt later in 2021. For example, how it affected their work and how they dealt with the changes in working practices. A second study presents an Interpretive Phenomenological Analysis of 18 interviews capturing the individual ‘life experiences’ of UK police officers and staff working in variety of policing roles during the pandemic. Key themes identified include the negative effects of working at home and the worry of spreading the disease to loved ones. Recommendations are made for how police forces can better support the wellbeing of officers and staff during pandemic scenarios and increase resilience. For example, by quickly identifying those officers and staff most vulnerable to the disease and/or most anxious generally at the start of a pandemic, to plan for how appropriate support can be provided, and acknowledge that police staff feel most isolated when working from home.

Logging out or leaning in? Social media strategies for enhancing well-being.

Social media use is endemic among emerging adults, raising concerns that this trend may harm users. We tested whether reducing the quantity of social media use, relative to improving the way users engage with social media, benefits psychological well-being. Participants were 393 social media users (ages 17-29) in Canada, with elevated psychopathology symptoms, who perceived social media to negatively impact their life somewhat. They were randomized to either (a) assistance to engage with social media in a way to enhance connectedness (tutorial), (b) encouragement to abstain from social media (abstinence), or (c) no instructions to change behavior (control). Participants' social media behaviors were self-reported and tracked using phone screen time apps while well-being was self-reported, over four timepoints (6 weeks in total). Results suggested that the tutorial and abstinence groups, relative to control, reduced their quantity of social media use and the amount of social comparisons they made on social media, with abstinence being the most effective. Tutorial was the only condition to reduce participants' fear of missing out and loneliness, and abstinence was the only condition to reduce internalizing symptoms, relative to control. No condition differences emerged in eating pathology or the tendency to make social comparisons in an upward direction. Changes in social media behaviors mediated the effects of abstinence (but not of tutorial) on well-being outcomes. Participant engagement and perceptions of helpfulness were acceptable, but the abstinence group possibly perceived the content as less helpful. In conclusion, using social media differently and abstaining from social media may each benefit well-being. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

The effect of social anxiety on social attention in naturalistic situations

ABSTRACT Background and Objectives This multimodal two-phase study investigated the impact of trait social anxiety on exploration, social attention, and autonomic responses in a naturalistic setting. We expected higher avoidance of potentially crowded spaces, reduced visual attention on other people, and heightened physiological arousal in social situations for participants with higher social anxiety levels. Design and Methods Eighty-seven participants, pre-screened for high variance in trait social anxiety, first completed a half-hour walk on a freely chosen route and subsequently had a staged social interaction with a confederate consisting of a non-interactive waiting phase and a short conversation. Results While social anxiety did not modulate the choice of route during the walk phase, socially anxious participants avoided gazing at other individuals in non-interactive situations, i.e., during the walk and the waiting phase. In contrast, during actual interaction, they showed increased visual attention towards the confederate’s face. Across all experimental phases, highly socially anxious individuals showed elevated heart rates, but this effect was independent of the social context. Conclusions This study showed that social anxiety affects social exploration behavior not in a way of general avoidance, but rather in nuanced adaptations depending on the concrete situation, likelihood of interaction and associated socio-evaluative threat.

Endowed with positive values and fatal weaknesses: Public art practices in post-industrial landscape --- A systematic review

Public art, due to its convenient participatory function and strong social integration ability, is being widely used in the protection, adaptive reuse and innovation of urban post-industrial landscape. In the process of urban renewal, although different forms of public art practice have brought many positive values and benefits to post-industrial landscape, such as the preference for sustainable development of the city, the continuation of urban context or the concern for local community residents based on “top-down” and “bottom-up” cases. Meanwhile, a series of fatal weaknesses arise are ultimately attributed to fragment and single protection of post-industrial landscape. The goal of this study is to systematically review and classify articles on the involvement of public art in post-industrial landscape (a process for screening articles was designed) in order to more clearly find out the positive values and fatal weaknesses of public art practice in various process of post-industrial landscape protection based on both “top-down” and “bottom-up” models. Most previous studies have focused on case analysis and have not discussed this issue or used this method. Therefore, the study is valuable. The conclusions of the study show eight positive values and seven fatal weaknesses in the application of public art practice in post-industrial landscape. It should be pointed out that “inspiring interaction and involvement” and “strengthening community identity,” are the most important factors in the practice of public art in post-industrial landscape. In the future stage, we should focus on and address the issue of "how to establish long-term artistic practice?” and “how we can better balance interests and rights among multiple stakeholders?" within public art academic ocean.

Clinical Features and Social Behavior of Patients with Schizophrenia

Background: currently schizophrenia remains one of the most disabling diseases. Its clinical manifestations, course and outcome are extremely diverse. At the same time, there is no strict parallelism between the formal severity of illness and behavioral disorders. The aim of review is to analyze the available data on the relationship between clinical symptoms and cognitive deficits in patients with schizophrenia and behavioral disorders identified in them. Material and Method: the narrative review systematizes the data about influence of various clinical symptoms and their course on the behavior of patients with schizophrenia during the prodromal period, active course of the disease and during remission. Special attention is paid to the role of cognitive impairment, as well as the prevention of socially dangerous actions of mentally ill patients. An original typology of behavior of patients with schizophrenia in remission is considered. Conclusion: the analysis of the reviewed studies determines the possibilities of targeted psychosocial influence in order to form socially adaptive behavior in patients with schizophrenia.

Chronic corticosterone exposure causes anxiety- and depression-related behaviors with altered gut microbial and brain metabolomic profiles in adult male C57BL/6J mice

Chronic exposure to glucocorticoids in response to long-term stress is thought to be a risk factor for major depression. Depression is associated with disturbances in the gut microbiota composition and peripheral and central energy metabolism. However, the relationship between chronic glucocorticoid exposure, the gut microbiota, and brain metabolism remains largely unknown. In this study, we first investigated the effects of chronic corticosterone exposure on various domains of behavior in adult male C57BL/6J mice treated with the glucocorticoid corticosterone to evaluate them as an animal model of depression. We then examined the gut microbial composition and brain and plasma metabolome in corticosterone-treated mice. Chronic corticosterone treatment resulted in reduced locomotor activity, increased anxiety-like and depression-related behaviors, decreased rotarod latency, reduced acoustic startle response, decreased social behavior, working memory deficits, impaired contextual fear memory, and enhanced cued fear memory. Chronic corticosterone treatment also altered the composition of gut microbiota, which has been reported to be associated with depression, such as increased abundance of Bifidobacterium, Turicibacter, and Corynebacterium and decreased abundance of Barnesiella. Metabolomic data revealed that long-term exposure to corticosterone led to a decrease in brain neurotransmitter metabolites, such as serotonin, 5-hydroxyindoleacetic acid, acetylcholine, and gamma-aminobutyric acid, as well as changes in betaine and methionine metabolism, as indicated by decreased levels of adenosine, dimethylglycine, choline, and methionine in the brain. These results indicate that mice treated with corticosterone have good face and construct validity as an animal model for studying anxiety and depression with altered gut microbial composition and brain metabolism, offering new insights into the neurobiological basis of depression arising from gut-brain axis dysfunction caused by prolonged exposure to excessive glucocorticoids.

Music therapy improves engagement and initiation for autistic children with mild intellectual disabilities: A randomized controlled study.

This study aimed to evaluate the effectiveness of music therapy (MT) for children with co-occurring autism spectrum disorder (ASD) and intellectual disabilities (ID) and explore whether pre-intervention quantitative electroencephalogram (qEEG) responses can predict outcomes. A randomized controlled trial was conducted with 33 children receiving MT and 34 receiving an active control therapy. Participants received either MT or a non-musical social skills intervention for 45 min weekly over 12 weeks. Primary outcomes were measured using the Childhood Autism Rating Scale (CARS-2), along with the parent-rated Social Responsiveness Scale (SRS-2) and video coding of social behaviors. Both conditions significantly improved in CARS-2 scores at 2 weeks and 4 months post-intervention, with no differences between MT and control conditions. No changes were found in SRS-2 scores. While both conditions showed reduced disengagement after intervention, only the MT condition showed increased engagement and initiation. Strong qEEG responses to social scenes and music predicted increased initiation, indicating its potential to help tailor interventions. These results support incorporating MT into standard services and further research on qEEG predictors.

Mother-infant interactive processes and infant behavioral and vagal stress recovery: Associations at 3, 6, and 9 months of age.

Mother-infant interactive processes, including matching social behaviors and repairing interactive ruptures, are proposed to foster infant stress functioning. However, little is known about the extent to which the concurrent relations between these dyadic processes and infant behavioral and vagal stress recovery change over the first year of life. In this study, 116 mother-infant dyads (55 girls) from a midwestern city in the United States completed the still-face paradigm at 3, 6, and 9 months. Using microcoding of infant and maternal behaviors (i.e., facial expressions, vocalizations, and gaze directions), we defined two dyadic states (positive match and mismatch) and measured dyadic matching as a composite of (a) the proportion of positive match and (b) latency to interactive repair (i.e., the average duration of mismatches), for the play and reunion episode, separately, at each time point. Infant behavioral and vagal stress recovery were assessed as the proportion of social engagement during the reunion episode and increases in respiratory sinus arrhythmia from the still-face to reunion episodes, respectively. At 6 and 9 months, higher levels of dyadic matching during the play episode were related to better infant behavioral and vagal stress recovery, controlling for matching during the reunion episode. At 3 months, the relation only emerged for infant behavioral stress recovery. These findings suggest that the dynamics of mother-infant interaction may play a key role in infant stress recovery, particularly during the second half of the first year when infants become more actively engaged in social interactions and their vagal systems become more mature. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Phenology and social status of the endemic Sable Island Sweat Bee, Lasioglossum sablense

Lasioglossum (Dialictus) sablense Gibbs, 2010 (Hymenoptera: Halictidae) is endemic to Sable Island, an isolated sandbar located about 160 km east of Nova Scotia, Canada. Lasioglossum sablense is currently listed as Threatened due to its restricted geographic distribution, and promoting its conservation requires detailed information about nesting phenology, behaviour, and other life history details. We combined measurements of body size, wear, and ovarian status from adult females collected from flowers in 2016 and 2017 with measurements and behavioural observations of foragers collected at the Sable Island Station in 2019 and 2022, to compile a preliminary description of flight phenology and social behaviour. Like many members of its genus, L. sablense exhibited a diphasic life history. Phase 1 began when large, fertilized adult females emerged from hibernation, began nest and brood cell construction, and foraged to provision Brood 1, which comprised both daughters and sons. Most nests initiated during Phase 1 reactivated during Phase 2, with adult Brood 1 daughters foraging to provision Brood 2. Observations of bees at nest entrances demonstrated that some reactivated nests contained multiple adult females. Phase 1 foragers were larger, less worn, and had marginally higher levels of ovarian development than Phase 2 foragers. Five large females collected during Phase 2 had high levels of wear, suggesting they were long-lived Phase 1 foundresses that resumed foraging during Phase 2. Taken together, these observations suggest a mix of univoltine (single generation) and bivoltine (two generation) life histories, as well as a mix of solitary and social behaviour in L. sablense.

Kesetaraaan Gender dan Implikasinya Terhadap Perilaku Sosial dalam Perspektif Sila Kelima Pancasila

This article discusses gender equality and its implications for social behavior in the perspective of the fifth principle of Pancasila. Using a literature-based qualitative research method, this article examines three main aspects, namely the condition of gender equality in Indonesia, the relationship between gender equality and the values of the fifth principle of Pancasila, and its impact on social behavior. Gender equality includes equal rights and opportunities for women and men in various fields, including education, employment and decision-making. Although the government has made steps to support gender equality, there are still inequalities that need to be addressed. This article aims to provide a deeper understanding of the importance of gender equality in building a just and civilized society in accordance with the values of Pancasila, especially the fifth principle.

Understanding of Health literacy among Healthcare students in Saudi Arabia: a cross-sectional study

Background and objectiveHealth literacy is the cognitive and social abilities that influence a person’s motivation and capacity to learn, comprehend, and use information to improve and maintain good health. We aimed to investigate Healthcare Students’ knowledge, attitudes, and practices regarding Health Literacy in the Riyadh Province of Saudi Arabia.MethodsThis study used prevalidated electronic questionnaires among healthcare undergraduates from colleges affiliated with Saudi University in Riyadh, Saudi Arabia, from December to April 2024. Healthcare students were asked to answer a self-designed online questionnaire sent to them through social media platforms.ResultsThe response rate was 560 out of 600 (93.3%); 293 of the 560 students (52.3%) were aged between 23 and 24 years (mean age was 21.29 SD = 1.852). The mean GPA among the students was 4.31(± 0.682). The average overall score for health literacy among healthcare students was 100.92 ± 11.80. The mean scores for knowledge were 24.17 ± 4.67, attitudes were 38.65 ± 4.20, and practice in health literacy was 38.09 ± 5.09. Among all healthcare students, 50.2% reported good knowledge, 54.1% had good attitudes, and 50.1% exhibited good practices in health literacy. However, students’ knowledge (p = 0.019) and training (p = 0.024) in health literacy were significantly associated with smoking cigarettes. Additionally, smoking shisha was significantly associated with students’ knowledge (p = 0.022), attitudes (p = 0.001), and practices (p = 0.001) in health literacy.ConclusionOur study highlights that half of the healthcare students reported limited knowledge, attitude, and practice in health literacy. Age, gender, and course of study did not show significant differences. Rather, students who did not smoke cigarettes or shisha were found to have higher knowledge, attitudes, and practice in health literacy compared to smokers. However, to improve health literacy, additional education and increased awareness are needed. Further investigation is warranted to address the factors related to poor health literacy.

“It definitely was consensual, but…”: Normative tensions about gendered heterosexuality and young women’s mixed feelings about sex

Sexual ambivalence—sex that is simultaneously wanted and unwanted—is not unusual in young women’s experiences with heterosex. Elucidating how gender and sexuality contribute to ambivalence is important for understanding how social forces shape oft-hidden sexual behaviors that affect women’s well-being. We draw on 20 interviews with young women in the United States to argue that mixed feelings about sex (psychological ambivalence) could stem from conflicting norms about heterosex (sociological ambivalence). Participants recalled wanting sex with partners because the characteristics met one set of social norms that valorized the encounters, but also discussed simultaneously not wanting those same experiences because of coexisting norms that stigmatized their behaviors. Such mixed feelings contributed to some women’s unease about experiences that they understood as explicitly consensual. In the end, the study highlights the importance of attending to the sociological study of ambivalence and its role in theorizing access to pleasurable, not just consensual, sex.

Augmentation of Endogenous 2-Arachidonoylglycerol Mitigates Autistic Behaviors of BTBR Mice.

The lipid-based endocannabinoid (eCB) system regulates a host of developmental, physiological, and pathological processes in the mammalian brain, and recent studies have suggested that dysfunction of eCB system may contribute to the neuropathology of autism spectrum disorder (ASD). However, specific contributions to ASD-related developmental, cognitive, and behavioral phenotypes remain largely unexplored. The current study was designed to investigate if enhancing eCB signaling by blocking 2-arachidonoylglycerol (2-AG) hydrolase can mitigate ASD-like behaviors in a mouse model, and if such effects are associated with suppression of inflammatory signaling, oxidative stress, or neuronal apoptosis. Intraperitoneal injection of the 2-AG hydrolase monoacylglycerol lipase (MAGL) JZL184 (4, 16, or 40mg/kg) elevated 2-AG and reversed eCB system metabolic enzymes and receptors expression deficits in BTBR T + ltpr3tf/J (BTBR) mouse model of ASD. Moreover, the hyperactivity, excessive stereotypy, impaired social behavior, and cognitive deficits characteristic of this animal model were significantly improved by JZL184. Concomitantly, JZL184 administration reversed the abnormal pro- and anti-inflammatory cytokine concentrations measured in the hippocampus of BTBR mice. In addition, JZL184 reversed the observed overexpression of pro-apoptotic Bax and underexpression of anti-apoptotic Bcl-2 in BTBR mice and enhanced neuronal numbers in hippocampal CA1 and CA3 regions. We also found that the behavioral test battery influenced eCB concentrations independently of JZL184 treatment. Collectively, these findings suggest that augmenting eCB signaling can mitigate ASD-related phenotypes by suppressing neuroinflammation and neuronal apoptosis.

A Survey on AI-Driven Mouse Behavior Analysis Applications and Solutions

The physiological similarities between mice and humans make them vital animal models in biological and medical research. This paper explores the application of artificial intelligence (AI) in analyzing mice behavior, emphasizing AI’s potential to identify and classify these behaviors. Traditional methods struggle to capture subtle behavioral features, whereas AI can automatically extract quantitative features from large datasets. Consequently, this study aims to leverage AI to enhance the efficiency and accuracy of mice behavior analysis. The paper reviews various applications of mice behavior analysis, categorizes deep learning tasks based on an AI pyramid, and summarizes AI methods for addressing these tasks. The findings indicate that AI technologies are increasingly applied in mice behavior analysis, including disease detection, assessment of external stimuli effects, social behavior analysis, and neurobehavioral assessment. The selection of AI methods is crucial and must align with specific applications. Despite AI’s promising potential in mice behavior analysis, challenges such as insufficient datasets and benchmarks remain. Furthermore, there is a need for a more integrated AI platform, along with standardized datasets and benchmarks, to support these analyses and further advance AI-driven mice behavior analysis.

A sexually dimorphic signature of activity-dependent BDNF signaling on the intrinsic excitability of pyramidal neurons in the prefrontal cortex

Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders with strong genetic heterogeneity and more prevalent in males than females. We and others hypothesize that diminished activity-dependent neural signaling is a common molecular pathway dysregulated in ASD caused by diverse genetic mutations. Brain-derived neurotrophic factor (BDNF) is a key growth factor mediating activity-dependent neural signaling in the brain. A common single nucleotide polymorphism (SNP) in the pro-domain of the human BDNF gene that leads to a methionine (Met) substitution for valine (Val) at codon 66 (Val66Met) significantly decreases activity-dependent BDNF release without affecting basal BDNF secretion. By using mice with genetic knock-in of this human BDNF methionine (Met) allele, our previous studies have shown differential severity of autism-like social deficits in male and female BDNF+/Met mice. Pyramidal neurons are the principal neurons in the prefrontal cortex (PFC), a key brain region for social behaviors. Here, we investigated the impact of diminished activity-dependent BDNF signaling on the intrinsic excitability of pyramidal neurons in the PFC. Surprisingly, diminished activity-dependent BDNF signaling significantly increased the intrinsic excitability of pyramidal neurons in male mice, but not in female mice. Notably, significantly decreased thresholds of action potentials were observed in male BDNF+/Met mice, but not in female BDNF+/Met mice. Voltage-clamp recordings revealed that the sodium current densities were significantly increased in the pyramidal neurons of male BDNF+/Met mice, which were mediated by increased transcriptional level of Scn2a encoding sodium channel NaV 1.2. Medium after hyperpolarization (mAHP), another important parameter to determine intrinsic neuronal excitability, is strongly associated with neuronal firing frequency. Further, the amplitudes of mAHP were significantly decreased in male BDNF+/Met mice only, which were mediated by the downregulation of Kcnn2 encoding small conductance calcium-activated potassium channel 2 (SK2). This study reveals a sexually dimorphic signature of diminished activity-dependent BDNF signaling on the intrinsic neuronal excitability of pyramidal neurons in the PFC, which provides possible cellular and molecular mechanisms underpinning the sex differences in idiopathic ASD patients and human autism victims who carry BDNF Val66Met SNP.

Parental Influences on Social Competence: An Investigation of Parenting Styles and Children's Social Behavior in Chengdu, Sichuan Province

Parental Influences on Social Competence: An Investigation of Parenting Styles and Children's Social Behavior in Chengdu, Sichuan Province

Genomic architecture in social insects is more strongly associated with phylogeny than social behavior

Abstract The evolution of sociality in insects has been predicted to reduce effective population sizes, in turn leading to changes in genome architecture, including higher recombination rates, larger genomes, increased GC-biased gene conversion (gBGC), and greater intragenomic variation in GC content to maintain castes through differential methylation. As the number of sequenced insect genomes continues to grow, it remains an open question which, if any, of these genomic features are consistent across social insect genomes. A major challenge to determining such commonalities has been the lack of phylogenetically controlled analyses across independent origins of sociality. Of the 15 Hymenoptera species for which recombination rate was available, social species had higher rates of recombination. Next, we conducted a broader analysis of genome architecture by analyzing genome assemblies for 435 species of Hymenoptera and 8 species of Blattodea to test if GC content, genome size, distribution of CpG sites or codon bias repeatedly differed between social and nonsocial species. Overall, there was little support for predictable changes in genome architecture associated with sociality across Hymenoptera, after accounting for phylogenetic relationships. However, we found a significant negative relationship between sociality and GC content within the family Apidae and a significant negative relationship between sociality and genome size within the family Halictidae. In all, these results suggest that unique origins of social behavior may produce unique trends in genomic architecture. Our study highlights the need to examine genome architecture across independent origins of social behavior.