The subject of the research is the theoretical and practical aspects of the development of social entrepreneurship in the context of the concept of social responsibility. The purpose of the work is to determine the essential features and factors of the development of social entrepreneurship in the context of the concept of social responsibility for using the opportunities and resources of large business to support it. The methodological basis of the article is the main theoretical and methodological provisions of economic science, regulatory and legislative acts of Ukraine, works of leading foreign and domestic scientists on economics, marketing and management of social enterprises and social responsibility of business. Results of work. The essence, signs and directions of development of social entrepreneurship in Ukraine are determined. Revealed insufficient rates and scope of its distribution. The forms of participation of large business in its support in the context of social responsibility are substantiated. The field of application of results. The results can be used by enterprises united by territorial communities, regional and state authorities, non-governmental organizations. Conclusions. It is determined that social enterprises form a special sector of entrepreneurial activity, being created with the aim of solving social problems. They are becoming more widespread and can rely not only on their own resources and the capabilities of their members. It is substantiated that this can be a large and long-term support of a large business in the form of startups, outsourcing, and the like.