This comprehensive study delves into the pivotal role of social determinants of health (SDOH) in shaping public health policies. Social determinants encompass a wide range of social, economic, and environmental factors that significantly influence health outcomes and disparities. By analyzing the intricate interplay between social determinants and public health policies, this study aims to elucidate the mechanisms through which societal factors influence population health and well-being. Drawing upon empirical evidence, case studies, and critical analysis, the study explores the impact of social determinants on health disparities, health behaviors, healthcare access, and quality. Furthermore, it examines the challenges and barriers in addressing social determinants within public health policy frameworks, including systemic inequalities and data measurement issues. The study also identifies strategies for integrating social determinants into public health policies, including policy recommendations, collaborative approaches, and community empowerment initiatives. Ultimately, this study underscores the imperative of adopting a socioecological approach to public health policymaking, one that recognizes and addresses the underlying social determinants to promote health equity and improve population health outcomes. Keywords: Social Determinants, Reshaping, Public Health Policies, Comprehensive Study