Abstract. Climate warming exacerbates the degradation of the mountain cryosphere, including glacier retreat, permafrost degradation, and snow cover reduction. These changes dramatically alter the local and downstream hydrological regime, posing significant threats to basin-scale water resource management and sustainable development. However, this issue is still not adequately addressed, particularly in mountainous catchments. We developed an integrated cryospheric–hydrologic model, the FLEX-Cryo model, to comprehensively consider glaciers, snow cover, and frozen soil and their dynamic impacts on hydrological processes. Taking the mountainous Hulu catchment located in the upper Heihe River of China as a case study, we utilized the state-of-the-art climate change projection data under two scenarios (SSP2-4.5 and SSP5-8.5) from the sixth phase of the Coupled Model Intercomparison Project (CMIP6) to simulate the future changes in the mountainous cryosphere and their impacts on hydrology. Our findings showed that under the medium-emission scenario (SSP2-4.5) and high-emission scenario (SSP5-8.5), by the end of the 21st century, the glacier will completely melt out around the years 2051 and 2045, respectively. The annual maximum snow water equivalent is projected to decrease by 41.4 % and 46.0 %, while the duration of snow cover will be reduced by approximately 45 and 70 d. The freeze onset of seasonally frozen soil is expected to be delayed by 10 and 22 d, while the thaw onset of permafrost is likely to advance by 19 and 32 d. Moreover, the maximum freeze depth of seasonally frozen soil is projected to decrease by 5.2 and 10.9 cm per decade, and the depth of the active layer will increase by 8.2 and 15.5 cm per decade. Regarding hydrology, catchment total runoff exhibits a decreasing trend, and the tipping point of glacier runoff occurs approximately between 2019 and 2021. Permafrost degradation will likely reduce the duration of low runoff in the early thawing season; the discontinuous baseflow recession gradually transitions into linear recessions, and the baseflow increases. Our results highlight the significant changes expected in the mountainous cryosphere and hydrology in the future. These findings enhance our understanding of cold-region hydrological processes and have the potential to assist local and downstream water resource management in addressing the challenges posed by climate change.