Introduction: Tobacco use is one of the leading preventable causes of death in Brazil and worldwide. In addition, tobacco consumption through different forms of smoking is associated with an increased risk of cardiovascular events. Objectives: We analyzed the prevalence of smoking among adults in Brazil, and cardiovascular mortality rates attributable to tobacco, from 1990 to 2019 Methods: The prevalence of current smokers was estimated using data from a cross-sectional, nationally representative survey (National Health Survey) and the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) from 2006 to 2019. Age-standardized mortality rates and the absolute number of deaths attributable to tobacco were obtained from the Global Burden of Diseases 2019. Results: The results indicate that 12.8% (95% CI, 12.4-13.2%) of adults use some tobacco product, being the use higher in males (16.2%; 95% CI, 15.6-16.9%) than in females (9.9%; 95% CI, 9.3-10.3%). The proportion of people over 18 years of age who smoke in 2019 was 12.6% (95% CI, 12.2-13.0%), 15.9% (95% CI, 15.3-16.6%) in males, and 9.6% (95% CI, 9.2-10.1%) in females, showing a significant decrease in the last three decades (34.8% in 1989). However, there was an increase of 0.5% in the prevalence compared to 2018, suggesting a change in the trends. In 2019, smoking was responsible for 65,693 deaths from cardiovascular disease in Brazil (39% of all deaths attributed to tobacco). Cardiovascular mortality attributable to smoking decreased from 88.0/100,000 inhabitants (95%UI, 81.3-94.3) in 1990 to 26.3/100,000 inhabitants (95% UI, 23.8-28.9) in 2019. Conclusions: The prevalence of tobacco consumption and cardiovascular mortality attributed to tobacco has decreased in Brazil in the past three decades. However, recent opposite trends call for attention, demanding innovation in addressing the prevention and reduction of smoking in Brazil.