Smecta Research Articles

Experimental study of ginsenoside Rg3 in the treatment of acute radiation proctitis in rat models

Objective To evaluate the efficacy of ginsenoside Rg3(GRg3) in the treatment of acute radiation proctitis in rat models. Methods On the 7th day after 21.5 Gy irradiation, 100 rats were divided into the control group (normal saline, n=20), GRg3 group (gavage of 20 mg/kg, 40 mg/kg and 80 mg/kg GRg3, n=20 for each dose) and Smecta mixture enema group (n=20). After 2 weeks, all rats were anesthetized with chloral hydrate (3 ml/kg) and approximately 5 ml of blood sample was collected from the abdominal aorta prior to sacrifice. The rectal tissues were taken and prepared for detection of Bax and NF-κB contents and HE staining to observe the pathological changes of the rectal tissues. After the blood samples were centrifuged, the supernatants were collected for ELISA to detect the serum levels of IL-2, IL-6, TNF-α and MPO in each group. Results In the GRg3 group, the serum inflammatory cytokines, serum MPO concentration and the concentration of Bax and NF-κB in the intestinal tissues of rats were decreased along with the increasing dose of GRg3. These parameters in the high-dose GRg3 group were significantly lower than those in the saline group (all P 0.05), suggesting that GRg3 exerted good therapeutic effect on acute radiation proctitis in rat models. Conclusions GRg3 can significantly reduce the concentration of inflammatory cytokines, Bax and NF-κB in the intestinal tissues of rat models with acute radiation proctitis, which is more efficacious than the normal saline. GRg3 can be used to treat acute radiation proctitis in rat models. Key words: Ginsenoside Rg3; Acute radiation proctitis; Rat

Clinical effect of Smecta and Kangfuxin Liquid in the treatment of patients with stomatitis and oral ulcer

Objective To explore the clinical effect of Smecta combined with Kangfuxin Liquid in the treatment of stomatitis and oral ulcer. Methods From January 2015 to April 2017, 102 patients with stomatitis and oral ulcers in Heji Hospital Affiliated to Changzhi Medical College were selected and randomly divided into observation group and control group according to the digital table.The patients in the control group were treated with stomatitis/oral ulcer sprays.The patients in the observation group were treated with Smecta combined with Kangfuxin Liquid.The therapeutic effect of the two groups was evaluated and analyzed. Results The overall therapeutic effect of the observation group (92.16%) was significantly better than that of the control group(72.55%), the difference was statistically significant(χ2=9.259, P<0.05). The mean ulcer and pain scores of the observation group were significantly lower than those of the control group(t1=-4.362, t2=-5.174, all P<0.05). Conclusion The combination of Kangfuxin Liquid and Smecta in the treatment of stomatitis and oral ulcers can effectively promote ulcer surface repair, help to reduce the local swelling and pain, and has positive role in improving patients' compliance and quality of life, it is recommended in clinical. Key words: Oral ulcers; Stomatitis; Rehabilitation of new liquid; Smecta

The efficacy of the bivalent of clostridium butyricum powder in the treatment of childhood diarrhea after pneumonia

Objective To observe the efficacy of the bivalent of clostridium butyricum powder in the treat-ment of childhood diarrhea after pneumonia .Methods 82 cases of patients with childhood diarrhea after pneumonia in our hospital were divided into two groups according to hospital sequence .42 cases of the control group were given symptomatic treatment with smecta and the 40 cases of the study group used bivalent of clostridium butyricum powder in basis of the control group .The diarrhea treatment time and length of stay ,the efficacy of the treatment were com-pared between the two groups .Results The total effective rate of the study group was 95.0% significantly higher than 71.4%of the control group,the difference was statistically significant （χ2 =8.05,P<0.05）.The study group′s duration of diarrhea were （2.3 ±1.1）d,pneumonia duration of treatment were （4.4 ±1.9）d,length of hospital stay were（4.5 ±2.1）d significantly lower than those of the control group ,the differences were statistically significant （t=7.39,7.35,7.39,all P<0.05）.Conclusion The bivalent of clostridium butyricum powder has a significant effect in the treatment of childhood diarrhea after pneumonia , which is worth to be applied in clinical application . Key words: Clostridium butyricum powder; Diarrhea; Pneumonia; Child

Smecta combined with TDP Irradiation for pressure sores

Objective To investigate the clinical efficacy of Smecta combined with TDP irradiation for treatment of pressure sores.Methods Selected 60 stroke patients with stage Ⅲ pressure sores,who had lay in bed for a long time,in our department of medicine from 2010 January to 2012 June.The patients were randomly divided into a experiment group of 30 cases,a total of 42 stage Ⅲ pressure sores,and control group of 30 cases,a total of 49 stage Ⅲ pressure sores.Based on the basic nursing of pressure sores,the patients in the experiment group were treated by TDP irradiation daily,with a 30-40 cm radiation distance of the probe from the pressure sore,20 min each time,and externally applied Smecta after that.Meanwhile the patients in the control group were treated externally applying Aner iodine basing on the basic nursing of pressure sores.The differences in size,color,scar,granulation tissue and inflammatory exudate of pressure sores between two groups were observed comparatively 14 days after the treatment.Results The healing time of the experiment group were significantly shorter than that of the control group (P＜0.05).The total efficacy rate was 93.35％ in the experiment group and 70％ in the control group.There was significant difference between the two groups (P＜0.05).Conclusion Smecta combined with TDP irradiation for pressure sores is clinically effective,convenient,cost-effective,operation-simple and suitable for application in basic hospital. Key words: Smecta; TDP irradiation; Pressure sore; Clinical effect

Effect evaluation of potassium sodium dehydroandrographolide succinate for injection in combination with smecta enema treatment for children with autumn diarrhea

Objective To observe the effect of potassium sodium dehydroandrographolide succinate for injection (PSDS)combining with smecta enema treatment on children with autumn diarrhea.Methods 102 children patients with autumn diarrhea were selected and divided into the control group,the PSDS group and the combination group with 34 patients in each group.The control group received symptomatic supportive treatment,based upon this,the PSDS group received PSDS,and the combination group adopted PSDS and smecta enema treatment.The treatment effect was compared between the three groups.Results The effect of the PSDS group and the combination group was better than the control group,the effect of the combination group was better than the PSDS group.Conclusions Combination of PSDS with smecta enema treatment for children with autumn diarrhea has significant effect,but enough attention should be paid to peri-anal nursing. Key words: Potassium sodium dehydroandrographolide succinate for injection; Enema treatment; Autumn diarrhea in children; Nursing

Therapeutic effects of smecta on multiorgans injury induced by paraquat in rats

Objective To evaluate therapeutic effect and the possible mechanism of smecta on paraqual plasma concentrations and multiorgans injury induced by paraquat intoxication in rats. Methods A total of 76 healthy adult SD rats were randomly ( random number) divided into group A (control group n =6),group B ( poisoned group n =30 ),group C (smecta-treated group n=30).Rats in groups B and C were treated intragastrically with PQ at 50 mg/kg,the rats in the group C were given with smecta at 50 mg/kg,while the rats in the other two groups were only intragastrically adminstered with saline.Live rats in groups B and C were sacrificed at 2,6,24,48,72 h after administration of PQ for the determination of paraquat plasma concentrations and for HE staining of lung,stomach and jejunum.The rats were executed at the end of trial by the same way in group A.All measurement data were expressed as means + standard deviation ((x) ±s).The data of pathological score were compared with Independent-samples T test and the data of PQ concentration compared with analysis of variance (ANOVA) followed by LSD-t multiple comparison test.P-values of less than 0.05 were considered statistically significant.Results The paraquat plasma concentration ( ng/ml ) was 440.314 ± 49.776 to 4320.6150 ± 413.947.There were different pathological changes of lung,stomach and jejunum in group B. Lung injuries gradually deteriorated,congestion,edema,leukocyte infiltration,incrassated septa and lung consolidation were observed.The pathological changes were obvious such as abruption of mucosa,hyperemic gastric mucosa and leukocyte infiltration in stomach.Haemorrhage of jejunum mucosa,abruption of villus,gland damage and inflammatory cell infiltration were found. Compared with group B,all the pathological changes mentioned above were obviously alleviated in group C ( P ＜ 0.05 ),and the concentrations reduced ( P ＜ 0.01 ).Conclusions Smecta reduced paraquat plasma concentrations and alleviated pathologic injury of rats with PQ poisoning. Key words: Smecta; Paraquat; Plasma concentration; Pathological change; Therapeutic effect

The efficacy of losec combined with smecta in the treatment of peptic ulcer hemorrhage

Objective To explore the efficacy of losec combined with smecta in the treatment of peptic ulcer hemorrhage. Methods 60 patients with peptic ulcer hemorrhage in our hospital from January 2009 to January 2010 were randomly assigned to receive combination therapy with famotidine and reptilase (control group),or losec combined with smecta (study group). Results The time to stomachache relief and time to hemostasis were shorter in the study group than in the control group,and there was a significant difference between the two groups (P＜0.05). The total effective rate differed significantly between the study group and the control group (96.67％ vs. 73.33％,P＜0.05). No marked adverse reactions were found in the two groups,except that one patient had mild chest distress in the study group.Conclusions Losec combined with smecta is effective in the treatment of peptic ulcer hemorrhage and thus is worth being used. Key words: Losec; Smecta; Peptic ulcer; Hemorrhage

Clinical observation of racecadotril granules in treating rotaviral enteritis in infants

Objective To investigate the curative effect of racecadotril granules on acute rotaviral enteritis in infants. Methods 100 infants with acute rotaviral enteritis were divided into combined treatment group(group A:50)cases and smecta group(B group:50 cases) ;Group B was given to basis of conventional therapy,but Group A received conventional therapy combined with clothing racecadotril particles. The efficacy and adverse reactions were observed.Results The time of improvement of vomiting,fever and diarrhea in A group was significantly shorter than the B group(t =2. 245,2. 298,2. 301, all P ＜ 0.05); The total effective rate 92. 0% in A group were higher than the B group 74. 0% after treatment 3d(x~2 = 3.987, P ＜ 0.05). The average course of treatment in A group (5.5 ± 0. 9) d was lower than the B group(7. 0 ± 1.1)d(t =7.17,P＜0.01). Conclusion Racecadotril is an effective and safe drug in treating rotaviral enteritis in infants. Key words: Rotavirus infections; Racecadotril graules; Child

Nursing of interferon combined with smecta on children with the oral ulcer of hand foot and mouth disease

Objective To accumulate nursing experience for the hand foot and mouth disease (HFMD)and explore the effective nursing measures on oral ulcer of HFMD through the clinical nursing of children with HFMD which caused by EV71.Methods There were 198 cases complicated with Oral Ulcer among 208 hospitalized children with HFMD from January to June in 2008 in Wuhan Children Hospital.198 cases were given human interferon1b via ultrasonic atomizing inhalation combined with smecta used in the position of oral ulcer after saline gargling.Results 198 cases had got good clinical results from 1 to 2 days,excellent clinical results from 2 to 4 days,and were cured in 5 days.208 children with HFMD were cured after antiviral and symptomatic supportive treatment,the hospitalization time was 5～31 d (mean,8.2± 0.4) d.Conclusions Interferon via ultrasonic atomizing inhalation combined with smecta have good dfficacy on the children with HFMD.They can shorten the course of disease,improve the symptoms and signs rapidly,and have the advantages of simple operation,efficiency,rapid,safety and easy acceptance by parents and children.It is worthy of recommendation. Key words: EV71 HFMD; Oral ulcer; Interferon; Smecta; Nursing

The clinical application of Dioctahedral smectite spreading partly for the recurrent oral ulcer

Objective Observe the curative effect of the treatment of recurrent oral ulcer with Smeeta in order to offer a kind of effective medicine for treatment of ROU with little side effect for the clinical practice.Methods 87 outpatients with recurrent oral ulcer, who were treated from June 2006 to June 2008, were selected and randomly divided into two groups:the therapy group was coated with Smeeta on the ulcer surface; the control group with iodine glycerin, and all of the groups stopped taking medicine. During the therapy,the average ulcer stage,the pain index and the local efficacy were recorded to evaluate the ulcer healing rates.Results the parameters such as average ulcer stage and pain index in therapy group were significantly better than those in control group (P<0.05);,The total effective rate was 88.9％ and59. 5％ respectively.Conclusions The treatment of recurrent oral ulcer with Smecta has effects on analgesia and ulcer concrescence promotion,so the treatment goal is reached and principle of therapy followed.It provides an effective drug for treatment of ROU with little side effect. Key words: Smecta ; Recurrent oral ulcer(ROU) ;

Treatment of Infantile Chronic Diarrhea with Shenlingbaizhu Powder and Smecta

Objective To observe clinical effect of treating infantile chronic diarrhea with Shenlingbaizhu powder and smecta.Methods 82 cases with chronic diarrhea were randomly divided into a control group and a treatment group.The control group was taken smecta orally,and the treatment group was taken Shenlingbaizhu powder together with smecta orally.10 days constitute a treatment course.Atier two courses,the therapeutic effects were observed in the treatment group and the control group respectively.Results The total effective rate was 92.9%and 77.5%in the treatment group the control group respectively,showing a significant difference(P＜0.05).Conclusion The treatment of infantile chronic diarrhea with Shenlingbaizhu powder and smecta has a better effect. Key words: Chronic diarrhea; Children; Shenlingbaizhu powder; Smecta

Clinical Observation on Treatment of Pediatric Diarrhea with Traditional Chinese and Western Medicine

Objective To study the clinical effects of tearing pediatric diarrhea with traditional Chinese and western medicine.Methods Altogether 520 patients with pediatric diarrhoea were recruited into three groups:the group treated with combined traditional Chinese and western medicine,the group treated with Chinese medicine and the group treated with western medicine.Observe clinical effects of each group.Results In 175 cases of the group treated with combined traditional Chinese and western medicine,66 cases show significant effects,64 cases are effective,45 eases are ineffective,and the effective rate is 74.30%;In 171 cases of the group of treated with traditional Chinese medicine,32 eases show significant effects,42 eases are effective,97 cases are ineffective,and the effective rate is 43.30%;In 174 eases of the group of treated with western medicine,35 eases show significant effects,43 eases are effective,96 eases are ineffective,and the effective rate is 44.80%.The effective rate of the group treated with combined Chinese medicine and western medicine was significantly better than the other two groups (P＜0.01).Conclusion Combined Chinese and western medicine is more effective in treating the patients with pediatric diarrhea,and it is worthy of spread. Key words: Pediatric diarrhoea; No1 and No2 Anti-diarrhoea powders; Smecta; Clinical observation

Clinical Observation on Treatment of Infantile Autumn Diarrhea with Western combined with Chinese Medicine 80 Cases

Objective To observe the clinical effect of treating infantile autumn diarrhea with methods of warring yang and strengthening spleen.Methods All 160 children with infantile autumn diarrhea were randomly recruited into a therapeutic group and a control group,with 80 children in each group.The treatment group was orally given Fuzi Lizhong Decoction and the control group was orally given Smecta and ZhengChangSheng Capsule.Intravenous fluid replacement was added for medium and severe patients.Calculate the therapeutic effect after three days.Results The total curative rate in the treatment group was 92.5%.contrasting with 75%in the control group.There was significant difference between the 2 groups(P＜0.05).Conclusion Chinese medicine combined with with Western medicine can get notable therapeutic effect in treating infantile autumn diarrhea. Key words: Infantile autumn diarrhea; Therapeutic method of warming yang and strengthening spleen

Nasal feeding of reptilase，cimetidine and smecta in the treatment of neonatal stress ulcer：A clincal study

目的 探讨立止血、甲氰咪胍和思密达联合鼻饲治疗新生儿应激性溃疡的疗效.方法 将156例新生儿应激性溃疡患儿分为对照组和治疗组各78例.对照组予常规的综合治疗;治疗组在综合治疗基础上予甲氰咪胍0.1g、立止血0.5 kU+生理盐水10 ml混匀经胃管注入,1 h后予思密达1 g+生理盐水10 ml摇匀经胃管内注入,两者均8 h一次;用至鼻饲管回抽无咖啡样液体后继续用1d.结果 治疗组和对照组总有效率分别为97%和74%,两组比较差异有显著性(x2=20.78,P＜0.05).结论 立止血、甲氰咪胍和思密达联合用药治疗新生儿应激性溃疡疗效突出,有利于尽早喂养.促进原发病的恢复。

Effect of 1% Sodium bicarbonate gastrolavage and smecta in the prevention of neonatal stress ulcer

目的 观察1%碳酸氢钠洗胃联合思密达预防新生儿应激性溃疡的疗效.方法 将120例高危新生儿随机分为治疗组和对照组,各60例.两组基础治疗相同,治疗组在此基础上加用1%碳酸氢钠洗胃及思密达.结果 治疗组应激性溃疡发生率、黄疸消退时间、病死率及治愈好转出院时间均明显低于对照组(P＜0.01).结论 1%碳酸氢钠洗胃联合思密达预防新生儿应激性溃疡效果显著。

Effect observation and nursing of smecta and HouFongSang used in treating children stomatitis

目的 观察双料喉风散与思密达交替用于治疗小儿溃疡性口腔炎的疗效及总结护理要点.方法将60例患儿随机分成治疗组及对照组各30例,治疗组分别给予双料喉风散及思密达,对照组则予涂1%复方龙胆紫溶液于口腔患处,观察口腔溃疡消退天数及其疗效,副作用等,并采用相应的护理措施.结果双料喉风散、思密达交替用于治疗小儿溃疡性口腔炎有效率为96.7%,对照组为57.0%,两组比较,差异有统计学意义(P＜0.01);治疗组的口腔炎消退天数为(3.8±2.1)天,对照组为(6.2±3.7)天,两组比较,差异有统计学意义(P＜0.01).结论双料喉风散、思密达交替用于治疗小儿溃疡性口腔炎,明显缩短病程并无毒副作用,是治疗小儿溃疡性口腔炎的有效方法。