A small, novel, integrated SHM system has been deployed during full-scale testing of a wing fatigue test for several weeks and a fuselage pressurisation test for several months. Complementary NDE measurement techniques were combined, with inputs from visible and infrared optical sensors, as well as resistance strain gauges. Sensor units were deployed at regions of interest and integrated board computers permitted near real-time data processing. The outputs were full-field measurement datasets from digital image correlation and thermoelastic stress analysis systems. Changes in these datasets in the regions of interest were successfully quantified using orthogonal decomposition and were indicative of changes in the condition of the structure. The results from these case studies demonstrate that this system can be successfully deployed in spatially restricted areas within airframe structures to monitor crack growth. The low cost and small footprint of the system presents the opportunity for installation of arrays of similar sensors for both test and in-service data collection. Near real-time data processing would allow timely reporting to service engineers, informing maintenance or operational decisions.