The current study is a strategic approach to corporate social responsibility (CSR); the aim is to put forward the factors of CSR activities that enhance its effectiveness for small and medium enterprises (SMEs). To achieve this objective, the factors were extracted from the literature and described along with trusteeship theory of Mahatma Gandhi, and an exploratory study was conducted and data were collected using structured questionnaire based on pretested scale from 158 SMEs and tested using partial least square regression (PLSR). The statistics shows the overall model fit, and the findings indicate a significant relationship with effective CSR. The results of the study are in accordance with the previous research work, and we also find that environment-related CSR and partnership are crucial for the effectiveness of CSR in SMEs, stakeholders’ role are important and SMEs’ CSR practice is still informal. The variables identified from study will help SMEs in establishing a formal approach towards CSR and meeting the needs of business and society in the twenty-first century.