The erosion of the dimple walls is investigated experimentally and numerically. A mathematical simulation framework was proposed to describe quantitatively the morphological evolution of the dimple wall quantitatively. As the wall shape continues to evolve, the wall shear stress, mesh deformation, and erosion rate would decrease and gradually tend to be constant. Two distinct regions have been identified along the dimple's windward wall surface: the wall's central area and the lateral area. In the central region, the wall profile flare occurs mainly in the early stage. In the lateral region, profile flare occurs mainly in the later stages of erosion. The microhardness of the wall surface shows a positive correlation with the erosion rate. The liquid-solid two-phase impinges on the wall at a smaller angle, and the wall material removal process is mainly based on the microcutting and slip mechanism. The results provide theoretical implications for the design of dimple-shaped, wide-channel welded plate heat exchangers.