To examine demographic and substance use factors associated with exclusive smokeless tobacco use (SLT) and dual use of both cigarettes and SLT among blue-collar workers. This cross-sectional study used data from the United States 2009 National Survey on Drug Use and Health. The sample (n=5,392) was restricted to respondents who were classified as blue collar workers by self-report primary job title. Various demographic variables, tobacco use and other substance use variables were examined. Respondents in this blue collar sample were 87% male and 64% Non-Hispanic White. An estimated 9.5% (SE=0.6) of respondents were current SLT users; 5.3% (SE=0.4) were current exclusive SLT users, and 4.2% (SE=0.4) were current dual users of both SLT and cigarettes. Factors related to exclusive SLT use were gender, marital status, age, race/ethnicity, type of blue-collar occupation, current binge drinking, and current marijuana use. Significant factors related to dual use were gender, marital status, age, race/ethnicity, type of blue-collar occupation, current cigar smoking, current binge drinking, and current illicit drug use. Rates of SLT use and dual use are high among U.S. blue-collar workers, indicating a need for targeted, workplace cessation interventions. These interventions may also serve as a gateway for addressing other substance use behaviors in this population.