Slow Wave Research Articles

A broadband and low-frequency sound absorber of sonic black holes with multi-layered micro-perforated panels

Sonic black hole (SBH) absorber is a promising strategy in noise reduction. However, low-frequency sound waves are difficult to be captured and dissipate due to the terminal truncation and the discontinuity of the admittance for the actual SBH. To make up the disadvantages, this paper incorporates micro-perforated panels (MPP) into the SBH to improve its low-frequency property. The design is realized by inserting the multi-layered MPPs (MLP) into the rings with decaying inner radius inside a SBH duct, termed the MLPSBH duct. The theoretical and numerical results show that the proposed absorber can achieve effective sound absorption in the frequencies above 225 Hz, in which the thickness of the absorber is only λ/15 with the λ being the corresponding wavelength. Mechanism studies indicate that the specific slow wave effect of the SBH can effectively mitigate the requirements for the absorber length. Closer examination reveals that the high acoustic resistance characteristics of the MLP remarkably compensate for the acoustic resistance mismatch of the SBH in low-frequency range. Thus, attributing to the interplay of the SBH and MLP effects, the proposed absorber achieves broadband and low-frequency sound absorption. Based on the deduction and validation of the transfer matrix method (TMM), the influence of the structural parameters on the sound absorption is investigated. The analysis indicates that the absorption performance of the proposed absorber barely depends on the damping and the number of rings, which allows the MLPSBH duct to maintain the excellent performance without abundant rings and extra absorbent material. The proposed strategy is an inspiration for the application of the SBH-based structures.

Hypersomnia as a predictor of response to intravenous ketamine/intranasal esketamine in treatment resistant depression

BackgroundSleep disturbances are highly prevalent in depressive episodes and are linked to higher mood severity and suicidal behaviors. Slow wave sleep (SWS) and REM sleep are compromised in depression. Current evidence suggests that rapid antidepressant effects of intravenous (IV) ketamine in patients with treatment-resistant depression (TRD) is mediated by its effects on SWS and REM sleep. Sleep phenotypes may help predict ketamine response. MethodIn this observational study, we investigated differences in rates of response among sleep phenotypes defined by QIDS-SR in a cohort of patients with TRD (n = 52) treated with IV ketamine or intranasal (IN) esketamine. Also, we explored a neurovegetative symptoms of atypical depression (NVSAD) phenotype and its association between response and change in QIDS-SR following the treatment with IV ketamine/IN esketamine. Results94 % of patients reported sleep difficulties and 62 % reported more than one sleep phenotype with middle and early insomnia being the most prevalent. Individuals with baseline hypersomnia showed higher response rates and more pronounced improvements on their QIDS-SR score. Additionally, 15 % of patients presented with NVSAD phenotype; the majority of whom achieved response and had higher reductions on QIDS-SR. A trend towards faster response was identified for hypersomnia and atypical depression phenotypes. LimitationsObservational study design and lack of a placebo group. ConclusionsOur data indicate that patients with TRD who have baseline hypersomnia and atypical depression features experienced a more substantial reduction in depressive symptoms and are more likely to achieve response with ketamine/esketamine. This could serve as a future predictor for clinical response.

Identification of slow waves in the evolution of KHI near the Venusian ionopause

The MHD slow waves in the evolution of Kelvin–Helmholtz instability (KHI) near the Venusian ionopause has been identified by using the magnetohydrodynamics equations. The diagnosis of slow waves utilizes two criteria: the phase speed and the ratio of density oscillation to the velocity oscillation. With the speed of sound greater than Alfvén speed, the phase velocity of slow waves along the initial magnetic field is approximately equal to Alfvén speed. For slow waves, the ratio of the density oscillation to the velocity oscillation along the initial magnetic field is independent of the angle between wave vector and the magnetic field. The data from the side of low-density were analyzed around the KH vortex. The numerical simulation results show that there are slow waves in the induced magnetosphere near the magnetopause of Venus. We also note that during the nonlinear growth stage, the parallel oscillations contribute approximately 76% ∼ 93% to the wave energy. This work will provide more clues that the KHI is a possible source of slow waves observed near Venus-like planets.

Acoustic stimulation during slow wave sleep shows delayed effects on memory performance in older adults

IntroductionIn young healthy adults, phase-locked acoustic stimulation (PLAS) during slow wave sleep (SWS) can boost over-night episodic memory consolidation. In older adults, evidence is scarce and available results are inconsistent, pointing toward reduced PLAS-effectiveness. We argue that multiple stimulation nights are required for effects to unfold in older individuals to compensate for age-related reductions in both SWS and memory performance. We test this assumption in a longitudinal within-subject design.MethodsIn a larger previous project, older adults participated in a three-night intervention receiving either real-PLAS (STIM group) or sham-PLAS (SHAM group). Encoding and immediate recall of face-occupation pairs was administered on the evening of the first intervention night (session one), with feedback-based retrievals ensuing on all following mornings and evenings across the intervention. To test for the benefit of the real-PLAS over sham-PLAS intervention within participants, 16 older adults [agemean: 68.9 (SD: 3.7)] were re-invited receiving the real-PLAS intervention exclusively. This resulted in a SHAMSTIM group (n = 9; T1: sham-PLAS intervention, T2: real-PLAS intervention) and a STIMSTIM group (n = 7; T1 and T2: real-PLAS intervention).ResultsWhile the STIMSTIM group exhibited highly similar responses during T1 and T2, the SHAMSTIM group exhibited a significantly higher increase in memory performance at T2 (real-PLAS) compared to T1 (sham-PLAS). These gains can be attributed to the late stages of the experiment, after three nights of real-PLAS, and remained stable when correcting for changes in baseline sleep quality (PSQI) and baseline cognitive ability (Montreal Cognitive Assessment) between T1 and T2.ConclusionsWe show that in older adults, PLAS-induced memory effects are delayed and manifest over the course of a three-night-PLAS intervention. Our results might explain the lack of effects in previous PLAS studies, where memory performance was solely assessed after a single night of PLAS.

Impact of Tool Eccentricity on Acoustic Logging Response in Horizontal Wells: Insights from Physical Simulation Experiments

Horizontal wells are extensively utilized in the development of unconventional reservoirs. However, the logging responses and formation evaluation in horizontal wells can be impacted by factors like anisotropy and tool eccentricity. To investigate the influence of tool eccentricity on acoustic logging response, physical simulation experiments of array acoustic logging were conducted in a scaled borehole formation model under different tool eccentricity conditions. The experimental data were analyzed, and the findings revealed that when the receiver array is parallel to the borehole axis, the P-wave slowness and S-wave slowness remain unaffected by tool eccentricity. However, the amplitudes of the P-wave and S-wave decrease significantly with increasing tool eccentricity, following an approximate negative exponential pattern. Additionally, when the transmitter is centered and the receiver array intersects the borehole axis at an angle, the wave velocities increase significantly with tool eccentricity, with the P-wave velocity showing a faster increase. Conversely, when the transmitter is eccentric and the receiver array intersects the borehole axis at an angle, the wave velocity decreases notably with tool eccentricity, and the P-wave velocity decreases even faster. These findings contribute to a better understanding of the impact of tool eccentricity on array acoustic logging response in horizontal wells and offer guidance for developing correction schemes to address this effect.

Pulsed Vibro-Acoustic Analysis Technique for Monitoring Bone Health in Preterm Infants: A Pilot Study.

Despite advances in neonatal care, metabolic bone disease of prematurity (MBDP) remains a common problem in preterm infants. The development of non-invasive and affordable diagnostic approaches can be highly beneficial in the diagnosis and management of preterm infants at risk of MBDP. In this study, we present an ultrasound method called pulsed vibro-acoustic analysis to investigate the progression of bone mineralization in infants over time versus weight and postmenstrual age. The proposed pulsed vibro-acoustic analysis method is used to evaluate the vibrational characteristics of the bone. This method uses the acoustic radiation force of ultrasound to vibrate the bone. The generated acoustic waves are detected using a hydrophone placed on the skin over the tibia. The frequency of vibration and the speeds of received acoustic waves have information regarding the material property of the bone. We examined the feasibility of this method through an in vivo study consisting of 25 preterm and 10 full term infants. The pulsed vibro-acoustic data were acquired longitudinally in preterm infants with multiple visits and at a single visit in full term infants. Speed of sound and mean peak frequency of slow and fast sound waves recorded by hydrophone were used to analyze bone mineralization progress. Linear mixed model was used for statistical analysis in characterizing the mineralization progress in preterm infants compared to data from full term subjects. Significance changes in wave parameters (speed of sound and mean peak frequency) with respect to the postmenstrual age and weight in preterm infants were observed with p-values less than 0.05. Statistical significances in speed of sound measurement for both fast and slow waves were observed between preterm and full term infants, with p-values of <0.01 and 0.02, respectively. The results of this pilot study indicate the potential use of vibro-acoustic analysis for monitoring the progression of bone mineralization in preterm infants.

Simulation and analysis of elastic waves in partially saturated double-porosity media based on finite difference method

Double-porosity poroelastic model takes into account the effect of mesoscopic flow induced by rock heterogeneity on dispersion and attenuation of elastic waves, and has obtained good application results in the quantitative explanation of seismic data in heterogeneous reservoirs. Wavefield simulation based on double-porosity model not only helps visualize the propagation characteristics of the elastic waves but also lays the foundation for seismic imaging. In this work, we perform wavefield simulation and analysis based on the Santos-Rayleigh model which incorporates mesoscopic and global flow in a partially-saturated double-porosity medium. Specifically, the mesoscopic flow mechanism is represented with a Zener viscoelastic model. The comparison shows that the Zener model can accurately capture the propagation characteristics of fast P-wave, but fails to describe the attenuation characteristics of slow P3 wave in the low-frequency band. It implies that Zener viscoelastic model and slow wave modes follow different mechanisms. Then the staggered grid finite-difference method is used to simulate wave propagation in a double-porosity medium, and the stiff problem is solved with a time-splitting algorithm, which can significantly improve computational efficiency. Based on the above methods, the correctness of our algorithm is verified with derived analytical solution for a P-wave source in a uniform partially saturated poroelastic medium. Analytical and numerical solutions are in good agreement and mean error is 0.33%. We provide some examples of wavefield snapshots and seismograms in homogeneous and layered heterogeneous media at seismic and ultrasonic frequencies. The simulation results demonstrate the strong attenuation of fast P-wave and no change of S-wave in the seismic band due to mesoscopic flow mechanism, which is consistent with the theoretical prediction of double-porosity model. Moreover, the energy of fast P-wave is concentrated in solid phase while slow waves are stronger in fluid phase. This work contributes to the understanding of broadband elastic wave propagation in a heterogeneous partially saturated porous medium and can be applied to the reservoir imaging with broadband geophysical data.

Transmission of slow waves in Masimo O3 near infrared spectroscopy measures

IntroductionCerebral autoregulation (CA) dysfunction is a key complication following brain injury. CA assessment using near-infrared spectroscopy (NIRS) offers a promising alternative to the current non-invasive standard, cerebral blood flow velocity (CBFV) measured with transcranial Doppler. Research questionCan autoregulatory slow waves (frequency range 0.005–0.05 Hz) associated with spontaneous and induced changes in ABP in healthy volunteers be detected by parameters measured with the Masimo O3 NIRS device? MethodsABP, CBFV and Masimo O3 parameters were measured in 10 healthy volunteers at baseline and during ABP oscillations induced by squat/stand manoeuvres. Transmission of slow waves was assessed with power spectral density and coherence analysis in NIRS signals and compared to that of CBFV. ResultsAt baseline, slow waves were detected with sufficient power that substantially exceeded the signals’ measurement resolution in all parameters except cerebral oxygen saturation. During ABP oscillations in the 0.033 Hz range (induced by squat/stand), the power of slow waves increased in all parameters in a similar pattern, with total (cHb) and oxygenated (O2Hb) haemoglobin concentrations most closely mirroring CBFV (median standardised power [first-third quartile], baseline vs squat/stand: CBFV 0.35 [0.28–0.42] vs 0.50 [0.45–0.62], O2Hb 0.47 [0.33–0.68] vs 0.61 [0.59–0.69]). Coherence with ABP increased for both CBFV and NIRS measures from low at baseline (<0.4) to high during induced changes (>0.8). ConclusionSpontaneous fluctuations in ABP can be observed in analysed Masimo O3 metrics to a varying degree. The clinical utility of Masimo O3 signals in CA assessment requires further investigation in brain injury patients.

Three-dimensional receptivity of a high-speed blunt cone to different types of freestream disturbances

Receptivity to freestream disturbances is the initial stage of the boundary-layer transition process, which can determine the final path of boundary-layer disturbance triggering transition. At present, researches on the receptivity of two-dimensional boundary layer to disturbances with zero incident angles, are relatively sufficient. In fact, the freestream disturbances often propagate into the boundary layer in the form of non-zero incident angles, resulting in a component of spatial disturbances in the circumferential direction of rotating bodies (such as a cone). It is a receptivity problem with a distinct three-dimensional feature. However, research on this three-dimensional receptivity problem is relatively scarce. The preliminary work only studied the three-dimensional receptivity to low-frequency incident slow acoustic waves. There has not been a systematic study on the three-dimensional receptivity to different types of freestream disturbances. The paper conducts a study on the three-dimensional receptivity of a blunt cone to different freestream disturbances. Firstly, a high-resolution numerical simulation method is used to compute the three-dimensional receptivity process by introduce freestream disturbances with 15 degree incident angles. The freestream disturbances include fast acoustic wave, slow acoustic wave, entropy wave, and vortex wave. Their frequencies are selected as dimensionless 1.1 and 5, corresponding to the frequencies of the first mode and second mode, respectively. Then, the phase velocity and shape function of the boundary-layer disturbances at each circumferential position for the numerical results are obtained by Fourier transform. To interpret the receptivity mechanisms, the corresponding results by linear stability analysis are obtained for comparisons. It is found that, the first and second modes of the boundary layer can be effectively excited by the incident slow acoustic waves; It is difficult for the incident fast acoustic waves to excite unstable modes in the boundary layer; The incident entropy wave and vortex wave are difficult to excite the first mode at low frequency, but can excite the second mode at high frequency. Furthermore, the incident angle of the freestream disturbances can cause the differences in the receptivity at different circumferential positions of the cone, which can be reflected in two ways. One is the difference in the dominant disturbance form at different circumferential positions; The second is the difference in the amplitude of boundary-layer disturbances. Under different disturbance types and frequencies, these differences between different circumferential positions exhibit different results. The strongest receptivity may occur on the incident front, the incident back, and the incident side. These phenomena may be the result of the combined action of the upstream head disturbances and the disturbances on the incident front.

Clinical phenotypes of developmental and epileptic encephalopathy-related recurrent KCNH5 missense variant p.R327H in Chinese children

KCNH5 gene encodes for the voltage-gated potassium channel protein Kv10.2. Here, we investigated the clinical features of developmental and epileptic encephalopathy (DEE) in five Chinese pediatric patients with a missense mutation (p.R327H) in KCNH5 gene. These patients had undergone video EEG to evaluate background features and epileptiform activity, as well as 3.0 T MRI scans for structural analysis and intelligence assessments using the Gesell Developmental Observation or Wechsler Intelligence Scale for Children. Seizure onset occurs between 4 and 10 months of age, with focal and generalized tonic-clonic seizures being common. Initial EEG findings showed multiple multifocal sharp waves, sharp slow waves or spike slow waves, and spike waves. Brain MRI revealed widened extracerebral space in only one patient. Mechanistically, the KCNH5 mutation disrupts the two hydrogen bonds between Arg327 and Asp304 residues, potentially altering the protein’s structural stability and function. Almost 80 % of patients receiving add-on valproic acid (VPA) therapy experienced a reduction in epileptic seizure frequency. Altogether, this study presents the first Chinese cohort of pediatric DEE patients with the KCNH5 p.R327H mutation, highlighting focal seizures as the predominant seizure type and incomplete mutation penetrance. Add-on VPA therapy was likely effective in the early stages of DEE pathogenesis.

Analytical and numerical solution of sausage MHD wave oscillation in a thin magnetic flux tube

&lt;p&gt;The aim of the present study is to investigate the damping of slow sausage MHD waves propagating in a gravitationally-stratified magnetic cylindrical structure when the plasma is strongly partially ionised. The problem is treated as an initial value problem and the analysis deals with the temporal evolution of waves in an asymptotic sense, i.e., large values of time compared to the period of waves. The plasma is assumed to be collision-dominated, i.e., we employ a two-fluid approximation. The set of equations describing the plasma dynamics is reduced to a coupled partial differential equations. Our findings show that the slow wave of charged species is affected by the presence of a cut-off. The mode associated with the neutral fluid propagates without any cut-off and decay very quickly due to collisions between particles.&lt;/p&gt;

Association of Epileptiform Discharge and Autism Spectrum Disorder Severity in Children Attending the Outpatient Clinics, Child Welfare Teaching Hospital, Baghdad

Background: Subjects with Autism Spectrum Disorder (ASD) have a higher prevalence of seizures than the general population, according to a significant body of research. Also, seizure-free patients with ASD have been found to have a higher prevalence of epileptiform discharge abnormalities compared to healthy controls across investigations. Changes in the electroencephalogram (EEG) can manifest as sharp waves or spikes, sharp and slow waves, generally distributed or general area, or focused, and can manifest in various brain regions. There is a necessity to search for a distinctive EEG characteristic in ASD patients. Objectives: This study used electroencephalography to investigate the relationship between interictal epileptiform discharges and the severity of ASD in children. Patient and methods: The study involved a total of 65 children. The first group consisted of 30 children (seven females and 23 males, 2-12 years of age) recruited from the autism center and the pediatric neurology consultancy clinic in the Child Welfare Teaching Hospital / Medical City. The second group consisted of 35 age- and gender-matched normally-developed children (10 females 25 males, 2-12 years of age) recruited from the Pediatrics Consultation Clinics in the Child Welfare Teaching Hospital. The ASD children met the DSM-5 criteria for autism and the Childhood Autism Rating Scale was utilized to determine the severity of autism. The electroencephalography signals were recorded to detect epileptiform discharge. The data was collected during the period from 5th October 2022 to 1st April 2023. Result: A statistically significant association was found between the epileptiform discharges and the study group (ASD Vs normally developed children). The EEG records were normal in 20 (66.7%), abnormal in the form of focal epileptiform discharge in 5 (16.7%), and in the form of generalized epileptiform discharge in 5 (16.7%) of ASD children. The EEG findings and the CARS-measured autism severity showed a statistically significant association (P=0.05), as the EEG abnormalities increased with the severity of autism. Conclusion: The degree of autism was found to be associated with the abnormalities of the electroencephalogram and the degree of autism. Received: May,, 2023 Accepted: Sept, 2023 Published: Jan. 2024

A numerical investigation of momentum flux and kinetic energy transfers between turbulent wind and propagating waves

This paper focuses on simulating turbulent flow over propagating waves by solving the full Navier–Stokes equations in a moving frame. A careful comparison of flow statistics with previous experimental and numerical results demonstrates, to some extent, the rationality of simplifying wind waves as turbulent flow over moving wave boundaries. The phase-averaging method is then applied to investigate the momentum and energy transfers between turbulent wind and waves propagating at slow, intermediate and fast speeds. The results suggest that the dominant mechanism for producing Reynolds shear stress (RSS) and turbulent kinetic energy (TKE) is related to the wave age. Slow waves produce RSS and TKE similar to a two-dimensional shear turbulence. However, a fast wave enhances the streamwise Reynolds normal stress, the windward side's negative RSS and the gradient of both streamwise and vertical velocities, leading to additional RSS and TKE productions that can be ignored under the slow wave regimes. A strengthening wave–turbulence exchange is also found for fast waves. The intermediate wave can be regarded as a transitional condition determining this change.

Col4a2 Mutations Contribute to Infantile Epileptic Spasm Syndrome and Neuroinflammation.

There are more than 70 million people worldwide living with epilepsy, with most experiencing the onset of epilepsy in childhood. Despite the availability of more than 20 anti-seizure medications, approximately 30% of epilepsy patients continue to experience unsatisfactory treatment outcomes. This situation places a heavy burden on patients' families and society. Childhood epilepsy is a significant chronic neurological disease that is closely related to genetics. Col4a2, the gene encoding the α2 chain of type IV collagen, is known to be associated with multiple diseases due to missense mutations. The Col4a2 variant of collagen type IV is associated with various phenotypes, including prenatal and neonatal intracranial hemorrhage, porencephaly, porencephaly with cataracts, focal cortical dysplasia, schizencephaly, strokes in childhood and adolescence, and sporadic delayed hemorrhagic stroke. Although epilepsy is recognized as a clinical manifestation of porencephaly, the specific mechanism of Col4a2-related epileptic phenotypes remains unclear. A total of 8 patients aged 2 years and 2 months to 18 years who were diagnosed with Col4a2-related infantile epileptic spasm syndrome were analyzed. The seizure onset age ranged from 3 to 10 months. Initial EEG results revealed hypsarrhythmia or multiple and multifocal sharp waves, spike waves, sharp slow waves, or spike slow waves. Elevated levels of the cytokines IL-1β (32.23±12.58 pg/ml) and IL-6 (45.12±16.03 pg/ml) were detected in the cerebrospinal fluid of these patients without any signs of infection. Following antiseizure treatment, decreased IL-1β and IL-6 levels in the cerebrospinal fluid were noted when seizures were under control. Furthermore, we aimed to investigate the role of Col4a2 mutations in the development of epilepsy. Through the use of immunofluorescence assays, ELISA, and Western blotting, we examined astrocyte activity and the expression of inflammatory cytokines such as IL-1β, IL-6, and TNF-α after overexpressing an unreported Col4a2 (c.1838G>T) mutant in CTX-TNA cells and primary astrocytes. We found that the levels of the inflammatory factors IL-1β, IL-6, and TNF-α were increased in both CTX-TNA cells (ELISA: p = 0.0087, p<0.001, p<0.001, respectively) and primary astrocytes (ELISA: p = 0.0275, p<0.001, p<0.001, respectively). Additionally, we conducted a preliminary investigation of the role of the JAK/STAT pathway in Col4a2 mutation-associated epilepsy. Col4a2 mutation stimulated astrocyte activation, increasing iNOS, COX-2, IL-1β, IL-6, and TNF-α levels in both CTX-TNA cells and primary astrocytes. This mutation also activated the JAK/STAT signaling pathway, leading to increased phosphorylation of JAK2 and STAT3. Treatment with the JAK/STAT inhibitor WP1066 effectively counteracted this effect in primary astrocytes and CTX-TNA cells. To date, the genes who mutations are known to cause developmental and epileptic encephalopathies (DEEs) are predominantly grouped into six subtypes according to function. Our study revealed that an unreported mutation site Col4a2Mut (c.1838G>T) of which can cause neuroinflammation, may be a type VII DEE-causing gene.

About one method for studying monitoring data for modeling potential seismic sources

Modeling a lumpy geological media using the theory of block structures and studying the conditions for the occurrence of resonance phenomena in the areas where blocks meet will make it possible to determine the locations of potential rearrangements associated with the development of natural disasters. In this paper we present a description of experimental data on the study of the Earth’s crust block structure used to construct a model for the propagation of slow deformation waves in the lithospheric structures of the region. Since the appearance of anomalies in the velocities of longitudinal waves indicates the emergence of geological rearrangements in the zone of a developing seismic event, a comprehensive method of active vibroseismic monitoring using a signal with linear frequency modulation and a harmonic signal is proposed to identify dilatant-type structures.

Theoretical Analysis of the Dispersion Characteristics for the Coaxial/Cylindrical Slow Wave Structure With Arbitrary Boundary Based on the Operator Theory

Theoretical Analysis of the Dispersion Characteristics for the Coaxial/Cylindrical Slow Wave Structure With Arbitrary Boundary Based on the Operator Theory

New Design and Simulation of Modified Helix Half-Ring Structure in TWTs Amplifier

The 3-D simulation of the traveling wave tube with attention to the vital role of the slow wave structure in the improvement of the lamp efficiency is done. The simulation shows that in the half ring helix with supporting rods (HRH-SRs), the RF signal phase velocity and the exchange of energy are improved than HRH. The HRH-SR with 1/16 length of HRH is introduced in the S-band. The HRH-SR structure is analyzed with the aid of the CST software for the cold and hot tests in the 2-4-GHz bandwidth. One of the interesting results is the linear output in the special frequency range, which have the industrial and technological importance. The other important result is that the proper impedance matching between the input and output is obtained in the HRH-SR structure in comparison with HRH.

Equivalent circuit model of the carrier-depletion-based push-pull silicon optical modulators withT-rail slow wave electrodes

Equivalent circuit model of the carrier-depletion-based push-pull silicon optical modulators withT-rail slow wave electrodes

Eurycoma longifolia (Tongkat Ali) supplementation enhances sleep and wake consolidation in wild-type, but not in narcoleptic mice.

Tongkat Ali (TA), also known as Eurycoma longifolia, has been used as a traditional herbal medicine for anti-aging, evidenced by clinical trials presenting the beneficial effects on energy, fatigue, and mood disturbance. We have recently shown that TA supplementation dose-dependently enhances the rest-activity pattern in C57BL/6 mice. Since destabilization of wakefulness and sleep is one of the typical symptoms of not only the elderly but also narcolepsy, we performed sleep analysis with and without dietary TA extract supplementation in middle-aged (10-12 months old) wild-type (WT) and narcoleptic DTA mice. We found that TA supplementation enhanced diurnal rhythms of locomotion and temperature in a time-of-day-dependent manner in WT mice but attenuated in DTA mice. In WT mice, TA supplementation consolidated wakefulness with a long bout duration and led to less entries into the sleep state during the active period, while it consolidated NREM sleep with long bout duration during the resting period. Neither disturbed sleep and wake cycles nor cataplexy was sufficiently improved in DTA mice. EEG spectral analysis revealed that TA supplementation enhanced slow wave activity (SWA) at both delta and low delta frequencies (0.5-4.0 and 0.5-2.0 Hz) during the light period, suggesting TA extract may induce vigilance during the active period, which then elicits a rebound effect during the resting period. Interestingly, DTA mice also slightly, but significantly, increased SWA at low frequencies during the light period. Taken together, our results suggest that TA supplementation enhances the Yin-Yang balance of sleep, temperature, and locomotion in WT mice, while its efficacy is limited in narcoleptic mice.

Compact Multibeam Antenna Array Facilitated by Miniaturized Slow Wave Substrate Integrated Waveguide Butler Matrix

Compact Multibeam Antenna Array Facilitated by Miniaturized Slow Wave Substrate Integrated Waveguide Butler Matrix