Slow Vital Capacity Research Articles

Airflow limitation is accompanied by diaphragm dysfunction.

Chronic airflow limitation, caused by chronic obstructive pulmonary disease (COPD) or by asthma, is believed to change the shape and the position of the diaphragm due to an increase in lung volume. We have made a comparison of magnetic resonance imaging (MRI) of diaphragm in supine position with pulmonary functions, respiratory muscle function and exercise tolerance. We have studied the differences between patients with COPD, patients with asthma, and healthy subjects. Most interestingly we found the lung hyperinflation leads to the changes in diaphragmatic excursions during the breathing cycle, seen in the differences between the maximal expiratory diaphragm position (DPex) in patients with COPD and control group (p=0.0016). The magnitude of the diaphragmatic dysfunction was significantly related to the airflow limitation expressed by the ratio of forced expiratory volume in 1 s to slow vital capacity (FEV(1)/SVC), (%, p=0.0007); to the lung hyperinflation expressed as the ratio of the residual volume to total lung capacity (RV/TLC), (%, p=0.0018) and the extent of tidal volume constrain expressed as maximal tidal volume (V(Tmax)), ([l], p=0.0002); and the ratio of tidal volume to slow vital capacity (V(T)/SVC), (p=0.0038) during submaximal exercise. These results suggest that diaphragmatic movement fails to contribute sufficiently to the change in lung volume in emphysema. Tests of respiratory muscle function were related to the position of the diaphragm in deep expiration, e.g. neuromuscular coupling (P(0.1)/V(T)) (p=0.0232). The results have shown that the lung volumes determine the position of the diaphragm and function of the respiratory muscles. Chronic airflow limitation seems to change the position of the diaphragm, which thereafter influences inspiratory muscle function and exercise tolerance. There is an apparent relationship between the position of the diaphragm and the pulmonary functions and exercise tolerance.

Reproducibility of Ventilatory Parameters, Dynamic Hyperinflation, and Performance in the Glittre-ADL Test in COPD Patients

ABSTRACTBackground: This study aimed to investigate the reproducibility of the ventilatory parameters and dynamic hyperinflation (DH) induced by the Glittre ADL-test (TGlittre) in chronic obstructive pulmonary disease (COPD) patients. Methods: Twenty-three patients with COPD underwent anthropometry, spirometry, TGlittre (TGlittre1 and TGlittre2) and pre- and post-test slow vital capacity. During the tests the ventilatory response was evaluated. Results: Regarding the TGlittre reproducibility, 87% of patients had a better performance in TGlittre2, and reduced on average 0.34 minute ± 0.62 (p = 0.01) from TGlittre1 time to TGlittre2, showing a learning effect of 6.34%. The difference average between tests was correlated with the time spent in TGlittre1 (r = −0.52; p < 0.05). The TGlittre time was statistically reproducible (intraclass correlation coefficient = 0.97; p < 0.001). Final ventilation parameters and their variations presented low-to-high reproducibility, except respiratory rate. The DH was similar (p > 0.05) in both tests, with low reproducibility in percentage, while in liters it was not reproducible. Conclusions: The TGlittre time and ventilatory parameters are reproducible, while DH is variable in COPD patients. A 6−7% learning effect was shown, and it is recommended to perform two tests.

Decline in Slow Vital Capacity Predicts Respiratory Insufficiency, Use of Assisted Ventilation, Tracheostomy or Death in ALS (P3.186)

Decline in Slow Vital Capacity Predicts Respiratory Insufficiency, Use of Assisted Ventilation, Tracheostomy or Death in ALS (P3.186)

A randomized, placebo-controlled, double-blind phase IIb trial evaluating the safety and efficacy of tirasemtiv in patients with amyotrophic lateral sclerosis

Our objectives were to evaluate the safety and tolerability of tirasemtiv over 12 weeks and its effect on the revised ALS Functional Rating Scale (ALSFRS-R) and other secondary functional measures. This randomized, double-blind, placebo-controlled trial enrolled adults with ALS and slow vital capacity (SVC) > 50% from 73 centers in eight countries. Patients who tolerated open-label tirasemtiv 125 mg b.i.d. for one week were randomized to double-blind treatment either to placebo or tirasemtiv, escalating to a maximum tolerated dose up to 250 mg b.i.d. The primary endpoint was the change from baseline in ALSFRS-R; secondary endpoints included SVC, maximum voluntary ventilation, sniff nasal inspiratory pressure, isometric muscle strength, and sub-maximum handgrip fatigue. Of 711 patients enrolled, 596 were randomized and received at least one dose of double-blind treatment. The primary endpoint showed no treatment effect (tirasemtiv: −2.98 ± 0.28, placebo: −2.40 ± 0.25, p = 0.114); however, SVC and muscle strength declined significantly more slowly on tirasemtiv (95% CI p = 0.0006, p = 0.0158, respectively). Dropouts and serious adverse events occurred more frequently in the tirasemtiv group. In conclusion, this was a negative study with respect to the primary endpoint; however, the effects on SVC and muscle strength suggest a potentially important effect of tirasemtiv warranting further evaluation over a longer period in ALS.

Acute effects of inspiratory muscle warm-up on pulmonary function in healthy subjects

The acute effects of inspiratory muscle warm-up on pulmonary functions were examined in 26 healthy male subjects using the pulmonary function test (PFT) in three different trials. The control trial (CON) did not involve inspiratory muscle warm-up, while the placebo (IMWp) and experimental (IMW) trials involved inspiratory muscle warm-up. There were no significant changes between the IMWp and CON trials (p>0.05). All the PFT measurements, including slow vital capacity, inspiratory vital capacity, forced vital capacity, forced expiratory volume in one second, maximal voluntary ventilation, and maximal inspiratory pressure were significantly increased by 3.55%, 12.52%, 5.00%, 2.75%, 2.66%, and 7.03% respectively, in the subjects in the IMW trial than those in the CON trial (p<0.05). These results show that inspiratory muscle warm-up improved the pulmonary functions. The mechanisms responsible for these improvements are probably associated with the concomitant increase in the inspiratory muscle strength, and the cooperation of the upper thorax, neck, and respiratory muscles, and increased level of reactive O2 species in muscle tissue, and potentially improvement of muscle O2 delivery-to-utilization. However, further investigation is required to determine the precise mechanisms responsible from among these candidates.

Los efectos cardiopulmonares del Cough Assist® son similares a los promovidos por la tos voluntaria en sujetos sanos. Ensayo clínico aleatorizado

ObjectiveTo analyse the haemodynamic and ventilatory effects of the application of Cough Assist® and compare them to those caused by the realization of voluntary cough. Material and methodsA randomised clinical trial. The sample consisted of 24 young healthy subjects who underwent three different protocols using Cough Assist® with common respiratory pressures into clinical practice: 30S – pressure I/E +30/–30 cmH2O; 50S – pressure I/E +50/– 50 cmH2O; and voluntary cough. Protocols apply to all subjects, with a time interval between them of at least 24hours. The parameters evaluated were heart rate, blood pressure, peripheral oxygen saturation, slow vital capacity and peak expiratory flow prior to application protocols (PRE), immediately after (POST) and 20minutes after (20’ POST). Statistical analysis was performed by ANOVA of i or ii pathways and post hoc of Bonferroni. For all analysis were considered a level of statistical significance of P<.05. ResultsThe effects caused by the Cough Assist® were similar to those of voluntary coughing. In women, none of them cause significant impact on the evaluated parameters; in men, both machine and voluntary cough led to increased heart rate, and the application of the Cough Assist® increased peripheral oxygen saturation. The other variables remained unchanged. ConclusionThe application of the Cough Assist® in medium and high pressure does not cause relevant cardiorespiratory repercussions, being similar to the physiological effects caused by the voluntary cough.

The Clinical Value of Deflation Cough in Chronic Coughers With Reflux Symptoms

Patients with deflation cough (DC), the cough-like expulsive effort(s) evoked by maximal lung emptying during a slow vital capacity maneuver, also present symptoms of gastroesophageal reflux. DC can be inhibited by prior intake of antacids. We wished to assess DC prevalence and association between DC and chemical characteristics of refluxate in patients with gastroesophageal reflux symptoms. A total of 157 consecutive outpatients underwent DC assessment and 24-h multichannel intraluminal impedance pH (MII-pH) monitoring; 93/157 also had chronic cough. Patients performed two to four slow vital capacity maneuvers and DC was detected aurally. Subsequently, they underwent 24-h MII-pH monitoring, the outcomes of which were defined as abnormal when acid or non-acid reflux events were >73. DC occurred in 46/157 patients, 18 of whom had abnormal MII-pH outcomes; 28 of the remaining 111 patients without DC also had abnormal MII-pH findings. Thus, in the patients as a group, there was no association between DC and MII-pH outcomes. DC occurred in 40/93 of the chronic coughers; 15 of whom had acid reflux. All but 2 of the 53 patients without DC had normal MII-pH outcomes (P< .001), and the negative predictive value of DC for excluding acid reflux was 96.2%. At follow-up, 65%of coughers showed significant improvement after treatment. The overall prevalence of DC was 29%, increasing to 43%in chronic coughers in whom the absence of DC virtually excludes acid reflux. Therefore, DC assessment may represent a useful screening test for excluding acid reflux in chronic coughers with reflux symptoms.

Effects of stretching the scalene muscles on slow vital capacity.

[Purpose] The purpose of this study was to examine whether stretching of the scalene muscles would improve slow vital capacity (SVC). [Subjects and Methods] The subjects of this study were 20 healthy female students to whom the study’s methods and purpose were explained and their agreement for participation was obtained. The SVC was measured using spirometry (Pony FX, COSMED Inc., Italy). The intervention used was stretching of the scalene muscles. Stretching was carried out for 15 min, 10 times at per each portion of scalene muscles: the anterior, middle, and posterior parts. [Results] Expiratory vital capacity (EVC) and tidal volume (Vt) noticeably increased after stretching. However, there were no changes in any of the SVC items in the control group. [Conclusion] This study demonstrated that stretching of the scalene muscles can effectively improve SVC. In particular, we confirmed that stretching of the scalene muscles was effective in increasing EVC and Vt, which are items of SVC.

Effectiveness of prophylactic non-invasive ventilation on respiratory function in the postoperative phase of pediatric cardiac surgery: a randomized controlled trial.

ABSTRACTObjectiveTo evaluate the effectiveness of prophylactic, non-invasive ventilation (NIV) on respiratory function in seven- to 16-year-old children in the post-operative phase of cardiac surgery.MethodA randomized, controlled trial with 50 children who had undergone cardiac surgery with median sternotomy. After extubation, patients were randomly assigned to one of two groups: control group (n=26), which received instructions regarding posture, early ambulation, and cough stimulation, and CPAP group (continuous positive airway pressure; n=24), which received the same instructions as the control group and CPAP=10 cmH20 twice daily for 30 minutes from the 1st to the 5th post-operative day (POD). As a primary outcome, lung function was evaluated before and on the 1st, 3rd, and 5th PODs with measures of respiratory rate (RR), tidal volume (TV), slow vital capacity (SVC), inspiratory capacity (IC), minute volume (MV), peak expiratory flow (PEF), and maximal inspiratory pressure (MIP). As secondary outcomes, the time of hospitalization and intensive care were recorded. A mixed, linear regression model and z-test were used to analyze respiratory function, considering p<0.05.ResultsAll variables, except RR and MV, showed a significant drop on the 1st POD, with gradual recovery; however, only MIP had returned to pre-operative values on the 5th POD in both groups. The RR showed a significant increase on the 1st POD, with a gradual reduction but without returning to baseline. In the intergroup analysis, significant improvement (p=0.04) was observed only in PEF in the CPAP group on the 1st DPO. The length of hospitalization and intensive care showed no significant differences.ConclusionNIV was safe and well accepted in this group of patients, and the protocol used was effective in improving PEF on the 1st DPO in the CPAP group.

Impact of Associating Tobacco to Chemicals Exposure on the Lung Function: Supply of Spirometry

Our study’s aim is to assess the impact of the combination of tobacco and chemical products (chlorine, sulphuric acid (sulphur)) on pulmonary function using the spirometry. Subjects selected were divided on 4 groups according to their smoking status and/or the exposition on chemical products. Parameters studied were: Slow Vital Capacity (SVC), Forced Vital Capacity (FVC), Forced Expiratory Volume in one second (FEV1), FEV1/VC (Tiffeneau), Peak Expiratory Flow Rate (PEFR). Ventilatory disorders were assessed in each group and comparison between groups was done. The comparative study of spirometry’s subjects who aren’t exposed on chemical products (G1vsG2), revealed that smokers (G2) had a VEMS more significantly low than the predicted standard value (P=0,003). When we compare nonsmokers (G1vsG3), exposed subjects showed a significant predominance of ventilatory disorders with CVL, VEMS and DEP weaker p=0,034(CVL), p=0,045(VEMS), p<0,001(DEP)). Among the smokers, we observed at chemical addicts, a significant reduction of CV (P=0,001(CVL); P<0,001(CVF)). Chemical addicts compared to tobacco addicts, presented a significant pre-eminence of ventilatory disorders (p=0,03(CVL), p=0,037(CVF), p=0,021(DEP)). Comparison between co-addicts(G4) and new subjects(G1), showed a variation rate more significantly low about CVL(P<0,001), CVF (P=0,003) and VEMS (P=0,021). Besides, the study of 12 co-addicts successive spirometries, on an average time of 3 years, showed in 80% of case, an evolution to ventilatory disorder. Moreover, subjects exposed on chlorine, compared with the ones exposed on sulphur, presented more ventilatory disorders (P<0,001). Then the chronic exposition on chemical products, tobacco impregnation constitutes a worsening factor of ventilatory disorders. Chlorine would be more toxic than sulphur.

To Correlate the Difference between Slow Vital Capacity and Forced Vital Capacity with the Severity of Chronic Obstructive Pulmonary Disease

To Correlate the Difference between Slow Vital Capacity and Forced Vital Capacity with the Severity of Chronic Obstructive Pulmonary Disease

Comparison of ventilatory restriction in techniques of respiratory physiotherapy and changes of position

Introduction: Body position affects the respiratory mechanics and could be favorable to pulmonary function when combined with respiratory physiotherapy. Objective: Was to compare the ventilatory restriction in respiratory therapy techniques and changes of position. Method: For analysis of lung volume was measured Slow Vital Capacity (SVC) in university students in the positions: sitting, dorsal decubitus (DD), DD with application of maneuver thoracic blockade of the right hemithorax and right lateral decubitus (RLD). In all maneuvers were instructed to perform an inspiration to total lung capacity and slow exhalation to residual volume. Results: It was evaluated 26 subjects with a mean age of 25.5 ± 11 years and mean body mass index of 25 ± 4 kg/m 2 . The values obtained from SVC sitting, DD, DD with blockade and DLD were respectively 3.5 ± 1.5 liters (87.7 ± 26.8%); 2.9 ± 1.4 liters (75.0 ± 26.5%); 3.0 ± 1.4 liters (75.2 ± 26.2%); 3.5 ± 1.6 liters (88.3 ± 29.4%). Using the SVC in a sitting position as compared, there was no statistical difference in DD (p = 0.024) and DD with position blockade (p = 0.036). There was no significant difference in the DLD (p = 0.459) position. Conclusion: Can conclude that the positions DD and DD with blockade reduced lung volume, whereas DLD position showed no significant difference when compared to sitting position, suggesting that this position is an option favorable position for respiratory therapy.

Pulmonary function and quality of life after VMAT-based stereotactic ablative radiotherapy for early stage inoperable NSCLC: a prospective study.

To analyze changes in pulmonary function and quality of life (QoL) at different time points after Stereotactic Ablative Radiotherapy (SABR) for early stage inoperable lung cancer, and potential correlations between radiation dose-volume parameters and pulmonary toxicity or changes in pulmonary function tests (PFT) and QoL. From July 2012 to October 2013, 30 patients were enrolled in this prospective observational study. Complete PFT were performed and Lung Cancer Symptoms Scale (LCSS) questionnaire administered prior to SABR; all patients then underwent Computed Tomography (CT) scan and PFT at 45, 135, 225 and 315 days after SABR, together with LCSS questionnaire. Clinical lung toxicity and radiological toxicity (acute and late) were prospectively recorded by using the Radiation Therapy Oncology Group (RTOG) scoring system. A decline in Slow Vital Capacity (SVC), Forced Expiratory Volume in 1s (FEV1), Single-breath lung diffusing capacity (DLCO) and blood partial pressure of oxygen (PaO2) was seen at 135 days post-SABR. PaO2 values rescued to normal levels at 315 days. None of the baseline PFT parameters resulted to be associated with the occurrence of pulmonary toxicity or with late radiological changes. Mean V5, V10, and V20 and MLD2Gy were higher in patients who developed radiation pneumonitis, even if not significantly associated at Cox regression analysis. LCSS QoL showed a significant worsening of the single item fatigue at 135 days after SABR. A small (mean 10%) but significant decline in lung volumes and DLCO was recorded after SABR, with clinical impact of such change difficult to estimate in individual patients. Global QoL was not significantly impaired. Dose-volume parameters did not emerge as significantly predictive of any clinical, radiological or functional toxicity.

Proposta de utilização da técnica de contagem como preditor da capacidade vital lenta em indivíduos hospitalizados

OBJETIVO:avaliar se existe correlação entre a capacidade vital lenta e o tempo máximo de fonação, mais especificamente pela técnica de contagem numérica e se é possível a partir do tempo máximo de fonação estimar a capacidade vital lenta em indivíduos hospitalizados.MÉTODOS:trata-se de um estudo do tipo transversal, crossover e a escolha das técnicas (espirometria e técnica de contagem numérica) foram realizadas de forma randomizada (sorteio simples). A capacidade vital lenta foi mensurada por meio da espirometria e o tempo máximo de fonação foi avaliado a partir da técnica de contagem numérica.RESULTADOS:participaram da pesquisa 221 pacientes hospitalizados. Foi verificada uma correlação positiva entre a capacidade vital lenta e o tempo máximo de fonação avaliados de forma absoluta (r = 0,75; p &lt; 0,001) e relativa (r = 0,76; p &lt; 0,001). A partir da regressão linear simples dos dados, foram verificados equações das retas analisadas de forma absoluta, Capacidade vital lenta = 55 Técnica de contagem numérica + 735 (r2= 0,56; p &lt; 0,0001) e relativa, Capacidade vital lenta = 0,84 Técnica de contagem numérica + 14 (r2= 0,57; p &lt; 0,0001).CONCLUSÕES:os resultados obtidos nesta pesquisa mostraram uma boa correlação entre as técnicas avaliadas, sendo possível estimar a capacidade vital lenta a partir da técnica de contagem numérica em indivíduos hospitalizados.

Erythropoietin in amyotrophic lateral sclerosis: a multicentre, randomised, double blind, placebo controlled, phase III study

ObjectiveTo assess the efficacy of recombinant human erythropoietin (rhEPO) in amyotrophic lateral sclerosis (ALS).MethodsPatients with probable laboratory-supported, probable or definite ALS were enrolled by 25 Italian centres and randomly assigned...

The checklist individual strength (CIS20-R) in patients with amyotrophic lateral sclerosis - a longitudinal study.

Fatigue may be underestimated symptom in amyotrophic lateral sclerosis (ALS). The self-administered checklist individual strength (CIS20-R) was used to measure both physical and mental fatigue in ALS. Fatigue was measured in 51 consecutive patients with ALS using the fatigue severity scale (FSS) and the CIS20-R (four dimensions: subjective fatigue experience, concentration, motivation, activity). The questionnaire scores were compared with disease and progression parameters [revised ALS functional rating scale (ALS-FRS-R), MRC sum score, slow vital capacity (slow VC)]. Patients had follow-ups at six and 12 months. At baseline (mean age: 57.9 years ± 12.3, mean disease duration: 15.8 months ± 12.7) clinical relevant fatigue was seen in 49% in FSS and 40% in CIS20-R. FSS and CIS20-R (except the subscale for concentration) were steadily increasing in the course of the disease. CIS1 (subjective fatigue) but not FSS showed a correlation to the ALS-FRS-R and the progression of the ALS-FRS-R after 12 months. There was a moderate positive correlation between FSS and CIS20-R. The CIS20-R is a sensitive tool to detect clinically relevant fatigue in early stages of ALS. Both physical and mental (motivation) dimensions of fatigue steadily increase during the course of the disease in ALS.

Effects of cervical self-stretching on slow vital capacity.

[Purpose] This study investigated the effects of self-stretching of cervical muscles, because the accessory inspiratory muscle is considered to improve pulmonary function. [Subjects] The subjects were 30 healthy university students 19–21 years old who did not have any lung disease, respiratory dysfunction, cervical injury, or any problems upon cervical stretching. [Methods] Spirometry was used as a pulmonary function test to measure the slow vital capacity before and after stretching. The slow vital capacity of the experimental group was measured before and after cervical self-stretching. Meanwhile, the slow vital capacity of the control group, which did not perform stretching, was also measured before and after the intervention. [Results] The expiratory vital capacity, inspiratory reserve volume, and expiratory reserve volume of the experimental group increased significantly after the cervical self-stretching. [Conclusion] Self-stretching of the cervical muscle (i.e., the inspiratory accessory muscle) improves slow vital capacity.

Study of computerized spirometric parameters of traffic police personnel of Saurashtra region, Gujarat, India

Background and Objectives:Air pollution due to road traffic is a serious health hazard and air quality crisis in cities is mainly due to vehicular emission. Thus the persons who are continuously exposed are at an increased risk. The study was carried out to evaluate the extent of impairment in lung function in traffic police personnel compared to matched unexposed control group.Materials and Methods:A cross-sectional study was conducted to measure the spirometric parameters of 100 traffic police personnel, aged 20-55 years, working in Saurashtra region, as compared to matched control group, consisting of 100 unexposed males. Measurement of lung volumes and capacities was done with SPIROEXCEL. The statistical analysis was carried out with Graph pad instat 3.Results:Traffic police personnel had significantly declined forced vital capacity (FVC), forced expiratory volume in one second (FEV 1), slow vital capacity (SVC) and maximum voluntary ventilation (MVV) when compared with predictive normal values, which is probably due to exposure to vehicular exhaust. Comparison of test values between groups showed significantly reduced FVC, MVV and increased FEV1/FVC ratio and insignificantly declined FEV1 and SVC in cases as compared to controls. Traffic personnel with longer duration of exposure showed significantly reduced lung functions than those with shorter duration. Smokers showed lower test values as compared to non-smokers with significance only in unexposed group.Conclusion:The effect of pollution by vehicular exhausts may be responsible for these pulmonary function impairments and traffic police personnel should be offered personal protective or preventive measures.

A comprehensive evaluation of respiratory status in patients with coronary artery disease undergoing coronary artery bypass surgery

The aim of the study was to analyze a potential role of lung function for a comprehensive evaluation of respiratory system in patients undergoing the coronary artery bypass surgery. Methods. The study involved 662 patients. Spirometry, body plethysmography and the singlebreath diffusing capacity for carbon monoxide (DLCO) were measured in all patients. All patients were divided into three groups according to the results of pulmonary function tests: patients with a known history of respiratory disease (n = 74; 11.2%), patients with newly diagnosed respiratory disease (n = 222; 33.5%) and patients without any respiratory disorders (n = 366, 55.3%). An integral index was calculated which characterizes the comprehensive pulmonary function evaluation based on weight coefficients. Results . Bronchial obstruction parameters, forced and slow vital capacities and diffusing capacity of alveolarcapillary membrane greatly contributed to the pulmonary function integral index. This index did not differed significantly between patients with newly and previously diagnosed respiratory diseases; however, it was significantly higher in patients without any respiratory disorders. Conclusion. A correlation analysis of the pulmonary function integral index, clinical and demographic data confirmed an inverse relationship between the pulmonary function integral index and duration of coronary artery disease, hypertension, number of previous myocardial infarctions, functional class of angina pectoris and congestive heart failure along with generally accepted factors affecting pulmonary function such as age, body mass index, smoking, and industrial xenobiotics.

Effect of yoga regimen on lung functions including diffusion capacity in coronary artery disease patients: A randomized controlled study.

Background:Lung functions are found to be impaired in coronary artery disease (CAD), congestive heart failure, left ventricular dysfunction, and after cardiac surgery. Diffusion capacity progressively worsens as the severity of CAD increases due to reduction in lung tissue participating in gas exchange.Aims and Objectives:Pranayama breathing exercises and yogic postures may play an impressive role in improving cardio-respiratory efficiency and facilitating gas diffusion at the alveolo-capillary membrane. This study was done to see the effect of yoga regimen on lung functions particularly diffusion capacity in CAD patients.Materials and Methods:A total of 80 stable CAD patients below 65 years of age of both sexes were selected and randomized into two groups of 40 each. Group I CAD patients were given yoga regimen for 3 months which consisted of yogic postures, pranayama breathing exercises, dietary modification, and holistic teaching along with their conventional medicine while Group II CAD patients were put only on conventional medicine. Lung functions including diffusion capacity were recorded thrice in both the groups: 0 day as baseline, 22nd day and on 90th day by using computerized MS medisoft Cardio-respiratory Instrument, HYP’AIR Compact model of cardio-respiratory testing machine was manufactured by P K Morgan, India. The recorded parameters were statistically analyzed by repeated measures ANOVA followed by Tukey's test in both the groups. Cardiovascular parameters were also compared before and after intervention in both the groups.Results:Statistically significant improvements were seen in slow vital capacity, forced vital capacity, peak expiratory flow rate, maximum voluntary ventilation, and diffusion factor/ transfer factor of lung for carbon monoxide after 3 months of yoga regimen in Group I. Forced expiratory volume in 1st sec (FEV1), and FEV1 % also showed a trend toward improvement although not statistically significant. HR, SBP and DBP also showed significant improvement in Group-I patients who followed yoga regimen.Conclusions:Yoga regimen was found to improve lung functions and diffusion capacity in CAD patients besides improving cardiovascular functions. Thus, it can be used as a complimentary or adjunct therapy along with the conventional medicine for their treatment and rehabilitation.