The paper is oriented on the architectural design of university schoolrooms with the link to ventilation. Today's architectural solution of university schoolrooms is not in accord with the possibilities of natural ventilation. In today's university schoolrooms, we can use just the natural ventilation therefore schoolrooms must be correctly ventilated by windows and doors. Correct and sufficient natural ventilation of university schoolrooms is very important because students spend majority of their time in the university in those schoolrooms. In Slovak universities, the natural ventilation is incorrectly and insufficiently provided. The biggest problem is the winter season, when the natural ventilation is provided just by opening doors into the corridor. By this way, sufficient supply of oxygen is not provided, what causes distractibility and feeling of tiredness by students. Therefore, the research was focused on the comparison and analysis of different ways of natural ventilation in university schoolrooms. Experimental measurements in university schoolroom were carried out, where the parameters of thermal comfort were measured at different systems of natural ventilation with the device Almemo 2590. Measurements were carrying out in two height levels, which were enabled by the change of the position of tripod, on which were mounted: temperature and humidity sensor, globe thermometer, turbulence sensor. Obtained values of air temperature, air relative humidity, air velocity, globe temperature and indexes PMV, PPD are presented in the graphs. On the basis of analysis of measured values is chosen the most suitable system of natural ventilation for university schoolrooms. Principles of architectural design for university schoolrooms are created for this optimal way of natural ventilation.