Objective To study the effects of rehabilitation exercise training on sleep quality and fatigue in hemodialysis patients with uremia. Methods A convenient sampling method was used to select 94 patients with uremia who underwent hemodialysis from September 2016 to September 2017. The patients were divided into routine group and training group according to the random number table method. example. The routine group was given routine hemodialysis care, and the training group was instructed to perform rehabilitation exercise training on the basis of routine group nursing. Both groups were intervened for 16 weeks. Pittsburgh Sleep Index (PQSI) was used to assess the quality of sleep. The sleep quality of the two groups before intervention, intervention for 8 weeks, and intervention for 16 weeks was compared. The fatigue scale (Fatigue Scale-14, FS-14) was used to assess the degree of fatigue. The degree of fatigue in the two groups before intervention, 8 weeks of intervention, and 16 weeks of intervention. Results Before the intervention, there was no significant difference in PQSI scores between the two groups (P>0.05). After 8 weeks of intervention, the PQSI values of the training group were significantly lower than those before the intervention (t=4.20, P 0.05), and the PQSI value of the training group (8.21±2.26) was significantly lower than that of the conventional group (10.15±3.19) (t=3.40, P 0.05). The PQSI values of the training group (6.97±2.32). PQSI values (8.93 ± 3.28) were significantly lower than those in the conventional group (t = 5.50, P 0.05). After 8 weeks of intervention, the FS-14 total score, physical fatigue score and mental fatigue of the training group. The scores were significantly lower than those before the intervention (t=3.83, 3.29, 2.64, P 0.05), and the FS-14 total score (7.02±1.12), physical fatigue score (5.30±1.55), and mental fatigue score (1.83±1.02) in the training group were significantly lower than those in the conventional group. -14 total score (9.01±2.14), physical fatigue score (6.23±1.72), mental fatigue score (2.66±1.37) (t=5.65, 2.75, 3.33, P 0.05), and The FS-14 total score (6.05±1.58), physical fatigue score (4.58±1.36), and mental fatigue score (1.35±1.10) in the training group were significantly lower than those in the conventional group (8.94±2.17), body. Fatigue score (6.33±1.82) and mental fatigue score (2.59±1.36) (t=7.34, 5.28, 4.86, P<0.05). Conclusion Rehabilitation exercise training can significantly improve the sleep quality of hemodialysis patients with uremia and reduce the fatigue degree of hemodialysis patients with uremia. It is worthy of clinical promotion. Key words: Rehabilitation exercise training; Uremia; Hemodialysis; Sleep quality; Fatigue