Skin Parameters Research Articles

Healthy human skin Kelvin-Voigt fractional and spring-pot biomarkers reconstruction using torsional wave elastography

This paper presents a novel method for reconstructing skin parameters using Probabilistic Inverse Problem (PIP) techniques and Torsional Wave Elastography (TWE) rheological modeling. A comprehensive examination was conducted to compare and analyze the theoretical, time-of-flight (TOF), and full-signal waveform (FSW) approaches. The objective was the identification of the most effective method for the estimation of mechanical parameters. Initially, the most appropriate rheological model for the simulation of skin tissue behavior was determined through the application and comparison of two models, spring pot (SP) and Kevin Voigt fractional derivative (KVFD). A numerical model was developed using the chosen rheological models. The collection of experimental data from 15 volunteers utilizing a TWE sensor was crucial for obtaining significant information for the reconstruction process. The study sample consisted of five male and ten female subjects ranging in age from 25 to 60 years. The procedure was performed on the ventral forearm region of the participants. The process of reconstructing skin tissue parameters was carried out using PIP techniques. The experimental findings were compared with the numerical results. The three methods considered (theoretical, TOF, FSW) have been used. The efficacy of TOF and FSW was then compared with theoretical method. The findings of the study demonstrate that the FSW and TOF techniques successfully reconstructed the parameters of the skin tissue in all of the models. The SP model’s the skin tissue η\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$\\eta $$\\end{document} values ranged from 8 to 12 Pa·s\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$Pa \\cdot s$$\\end{document}, as indicated by the TOF reconstruction parameters. η\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$\\eta $$\\end{document} values found by the KVFD model ranged from 4.1 to 9.3 Pa·s\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$Pa \\cdot s$$\\end{document}. The μ\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$\\mu $$\\end{document} values generated by the KVFD model range between 0.61 and 96.86 kPa. However, FSW parameters reveal that skin tissue η\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$\\eta $$\\end{document} values for the SP model ranged from 7.8 to 12 Pa·s\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$Pa \\cdot s$$\\end{document}. The KVFD model determined η\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$\\eta $$\\end{document} values between 6.3 and 9.5 Pa·s\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$Pa \\cdot s$$\\end{document}. The KVFD model presents μ\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$\\mu $$\\end{document} values ranging between 26.02 and 122.19 kPa. It is shown that the rheological model that best describes the nature of the skin is the SP model and its simplicity as it requires only two parameters, in contrast to the three parameters required by the KVFD model. Therefore, this work provides a valuable addition to the area of dermatology, with possible implications for clinical practice.

Analysis of the effect of components of chemical peels based on lactic and mandelic acid on skin parameters

Up to now, research studies have compared various peeling substances affecting the skin, without taking into account the parameters responsible for the penetration and potency of the compounds. The aim of this study was to analyze the effects of lactic acid and mandelic acid on hydration, melanin, sebaceous gland activity and the stratum corneum barrier. Equal concentrations of chemical peels, similar pH of the solutions, and the base enabled comparison of results. A series of treatments with lactic acid resulted in a decrease in transepidermal water loss, an increase in hydration levels and a reduction in sebaceous gland activity, as well as a significant drop in melanin levels. Mandelic acid applied in a series of four treatments resulted in a noticeable improvement in the appearance of the epidermis. The activity of the sebaceous glands also decreased significantly. The use of both, a series and a single treatment with mandelic acid, strengthened the epidermal barrier. Comparing a series of treatments and a single procedure it was found that the value of transepidermal water loss increased. The study demonstrated that whereas many carboxylic acids exhibit similarities, they also possess notable distinctions in their topical effects and medicinal applications.

Evaluation of the efficacy of a sunscreen containing ultra-long UVA1 and other UVR broad-spectrum filters on skin barrier protection and melanin content reduction in Chinese adults: A single-center study.

The protection for ultra-long UVA1 is lacked in the market, posing potential damage from ultra-long UVA1 irradiation. The study aims to evaluate the efficacy of a sunscreen containing multiple components, especially Mexoryl® 400 for improving skin barrier function and reducing melanin content. This single-center study included adults with sensitive and normal skin in China in November 2022. Participants received the test sunscreen for 4 weeks. Melanin and hemoglobin content, sebum secretion skin hydration, and trans-epidermal water loss were evaluated at T0d, T7d, and T28d. The self-assessment was done at T15min, T7d, and T28d. Sixty participants were included, including 30 self-claimed sensitive skin in the sunscreen group. The sunscreen demonstrated significant improvements in skin parameters. Skin redness reduced by 9.84% at T28d, sebum content in the forehead area decreased by 22.70% at T28d, and skin stratum corneum hydration increased by 38.44% at T28d, p < 0.001 respectively. Most notably, skin melanin content significantly reduced by 13.49% after 4 weeks' usage (p < 0.001). No adverse reactions were reported in either group. The study sunscreen improved the skin condition by decreasing the melanin content, regulating skin barrier function, and achieving a balance of skin hydration and sebum secretion.

Twelve Week Study Evaluating the Efficacy of a Novel Standardized Nutraceutical to Improve Acne and Skin Health

INTRODUCTION&#x0D; Although acne is generally viewed as the result of a localized immune response at the pilosebaceous unit, it is a condition with multifactorial etiology. While conventional treatments have focused primarily on the four major pathogenic factors, nutraceuticals offer an alternative or complementary approach to address more systemic, intertwined mechanisms involved in acne pathogenesis. These include stress, diet and metabolism, skin and gut microbiome, hormonal fluctuations, oxidative stress, and immune function. Therapies which target these underlying mechanisms have gone largely unexplored as ways to address acne. Here, we present the results of a novel nutraceutical addressing these root causes in patients with non-cystic acne. &#x0D; DESIGN&#x0D; This was a 12-week single-arm prospective study for adults aged 18-50 with facial non-cystic acne ranging from mild to severe. Subjects discontinued all acne medications and topicals prior to the start of the study. Clinical assessments at baseline, week 4, 8 and 12 included IGA, inflammatory and non-inflammatory lesion counts, clinical grading of PIH/PIE, and texture. Bioinstrumentation included corneometer, tewameter and sebumeter measurements. Questionnaires on perception of efficacy were also completed.&#x0D; RESULTS&#x0D; Fifty-one subjects were recruited with 39 subjects completing the study. The majority were female (67%); racial/ethnic background was comprised of white/caucasian (41%), black (41%) and Asian (13%). Reasons for discontinuation were: lost to follow up/withdrawal (n=7), non-compliance (n=1) and adverse events (n=4). Significant and progressive improvements were seen starting at week 4 in IGA with 85% of subjects showing significant improvements for acne severity at week 12. All lesion counts decreased over the duration of the study with a significant proportion of subjects seeing improvements in inflammatory lesion counts (69%) and non-inflammatory lesion counts (87%). Overall, clinical grading of skin quality parameters progressively improved throughout the duration of the study. Notably PIH/PIE parameters significantly improved in nearly 80% of subjects by week 12. Sebumeter measurements improved significantly with a decrease of 25% as early as week 4 and remained lower than baseline throughout the duration of the study. Skin hydration as measured by the corneometer improved as well. Subjective impressions of improvement as measured by the questionnaire at 12 weeks showed subjects had ‘less breakouts’ (77%), ‘less oily skin’ (74%) and that their ‘acne had improved’ (87%).&#x0D; CONCLUSION&#x0D; The paucity of scientific evidence and lack of clinical data on the efficacy of CAM, including nutraceuticals, have limited their recommendation for use in acne. This proof-of-concept study showed improvements in acne and skin parameters. Although more studies are needed, these results offer insight into the potential benefits of nutraceuticals addressing underlying mechanisms that up to now, have gone largely unexplored. Addressing root causes that contribute to a generalized inflammatory response leading to the development of acne may prove to be an important step in expanding our toolbox in providing more options for patients and improving skin health.

The Influence of Skin Parameters and Body Composition on the Tolerance of Pain Stimulus Generated During Electrical Muscle Stimulation (EMS) in Women - Pilot Study.

This pilot study aims to explore how skin parameters and body composition impact the tolerance to EMS (Electrical Muscle Stimulation) stimuli in women, particularly focusing on pain tolerance in response to varying intensities of EMS. This research seeks to understand what is essential for optimizing EMS applications. The study involved 16 females (age 35.9 ± 12.3). Body composition and anthropometric measurements were taken, including BMI (Body Mass Index), weight percentage, WHtR (Waist to Height Ratio), WHR (Waist-Hip Ratio), and Bioelectrical Impedance Analysis. High-frequency ultrasound scans were conducted to assess skin parameters. The EMS stimulation was performed using an Evolvex (InMode, Israel), with applicators placed around the abdomen and intensity adjusted according to patient tolerance, recorded at the pain threshold. The maximum tolerated EMS stimulus varied from 12V to 55V, with a median of 33V. Body weight showed a strong positive correlation (R=0.76, p<0.001) and hip circumference (R=0.66, p<0.001) with EMS intensity. Body fat mass (R=0.61, p=0.012) and visceral fat area (R=0.55, p=0.029) were positively correlated with EMS intensity. However, no significant correlations were observed between EMS tolerance and muscle tissue parameters or total body water content. The study also found that skin structure parameters showed no significant impact on EMS tolerance. The study reveals that women's tolerance to EMS stimuli is influenced by various factors. Anthropometric parameters like hip circumference, body weight, skinfold, and BMI are strongly correlated with EMS tolerance. Body composition factors, particularly adipose tissue characteristics such as body fat mass and percentage, also significantly impact EMS intensity requirements, with no notable correlation to muscle tissue or water content. However, variations in skin structure, including thickness and density, do not significantly affect EMS tolerance. These insights are crucial for tailoring personalized EMS therapy to enhance effectiveness and comfort in both aesthetic and rehabilitative applications.

Microwave study of the effect of cold argon plasma on functional state of rat’s skin

The purpose of this study was a comparative study of the dielectric parameters of rat skin when treated with argon and argon cold plasma. The experiment was performed on 40 male Wistar rats divided into 4 equal groups. The first group of animals (n=10) was a control (intact). The rats of the remaining groups (n=10 in each) were treated daily with a pre-epilated area of the skin of the back (area = 1x1 cm). The duration of the course for all experienced groups is 10 procedures. Animals of the second group were treated with a non–ionized argon stream (the duration of one procedure was 1 minute), rats of the third and fourth groups were treated with argon cold plasma (1 and 2 minutes, respectively). Cold plasma generation was performed using a device using the principle of microwave ionization of a gas stream. Argon of high purity (99.99%) was used as the latter. The dielectric parameters of the skin of animals in the treated area (in control group rats – at a similar point in the back) were evaluated upon completion of a full course of exposure. For this purpose, a specialized software and hardware complex was used, providing near-field resonant microwave probing of biological tissues. It was found that the course treatment of the skin of the back of rats with gas streams with different ionization causes the formation of a specific functional-metabolic and morpho-structural response. Its character is determined by the parameters of the gas flow used: non-ionized argon significantly reduces the dielectric parameters (permeability and conductivity), and the result of the action of cold argon plasma depends on the exposure. During one-minute treatment, tissue permeability was observed to remain intact with a moderate decrease in conductivity. In the case of an increase in the exposure time to 2 minutes, the dielectric constant increased, and the conductivity remained unchanged.

A systematic review of randomized controlled trials on the health effects of chocolate enriched/fortified/supplemented with functional components.

The most significant contributor to global mortality are cardiovascular diseases. Dietary factors significantly impact the risk, advancement, and treatment of cardiometabolic conditions. Chocolate, known for its adaptability and capacity to stimulate pleasure centers, emerges as a promising vehicle for integrating different bioactive elements. This systematic review analyzed 10 randomized controlled trials investigating the health effects of consuming enriched, fortified, or supplemented chocolate. These trials varied in chocolate intake amounts (ranging from 5 to 101 g day-1), incorporated bioactive components (co-crystalized astaxanthin, lycopene, wood-based phytosterol-phytostanol mixture, canola sterol esters, etc.), and duration (from 2 weeks to 1 year). Some enriched chocolates were found to reduce total and LDL cholesterol and influence markers of oxidative damage, inflammation, immune function, and skin parameters. However, certain trials showed a minimal impact on health outcomes. Therefore, while enriched chocolate holds promise as a carrier for beneficial bioactive compounds, rigorous scientific inquiry and methodological rigor are crucial to fully substantiate these claims. Comprehensive evaluations covering cardiovascular health, metabolic function, immune response, and other aspects are needed to understand its potential benefits and limitations. Advancing robust research initiatives could help realize the full potential of enriched chocolate in promoting human health and well-being.

Identification of threats during the bodywork and paint repair process

Body repairs are often based not so much on procedures as on the experience of the people who perform these repairs. The problem is that heat repairs change the internal structure of the vehicle's skin. When obtaining homologation, manufacturers must prove the specific strength of the materials during crash tests. During a bodywork repair, these parameters may change, and after the repair, there is no obligation to check the strength parameters of a specific element or system. By interfering with the structure, we cannot be sure that we still maintain an appropriate level of security. Therefore, during further tests, together with a team from the Bydgoszcz University of Technology, we plan to check the strength parameters of the vehicle's skin after repair. And what impact on the structure of the material is the duration of individual stages of sheet metal work, the intensity of the current and the temperature to which the material is heated in order to optimize the parameters and increase the level of safety of users.

Magneto-responsive biocomposites in wound healing: from characteristics to functions.

The number of patients with non-healing wounds continuously increases, and has become a prominent societal issue that imposes a heavy burden on both patients and the entire healthcare system. Although traditional dressings play an important role in wound healing, the complexity and diversity of the healing process pose serious challenges in this field. Magneto-responsive biocomposites, with their excellent biocompatibility, remote spatiotemporal controllability, and unique convenience, demonstrate enticing advantages in the field of wound dressings. However, current research on magneto-responsive biocomposites as wound dressings lacks comprehensive and in-depth reviews, which to some extent, restricts the deeper understanding and further development of this field. Based on this, this paper reviews the latest advances in magnetic responsive wound dressings for wound healing. First, we review the process of skin wound healing and parameters for assessing repair progress. Then, we systematically discuss the preparation strategies and unique characteristics of magneto-responsive biocomposites, focusing on magneto-induced orientation, magneto-induced mechanical stimulation, and magnetocaloric effect. Subsequently, this review elaborates the multiple mechanisms of magneto-responsive biocomposites in promoting wound healing, including regulating cell behavior, enhancing electrical signal, controlling drug release, and accelerating tissue reconstruction. Finally, we further propose the development direction and future challenges of magnetic responsive biomaterials as wound dressings in clinical application.

Regional Biophysical Variations in Canine Atopic Dermatitis: Non-Invasive Mapping of Skin Parameters

Regional Biophysical Variations in Canine Atopic Dermatitis: Non-Invasive Mapping of Skin Parameters

The impact of oral sea-buckthorn oil on skin, blood markers, ocular, and vaginal health: A randomized control trial

Sea buckthorn have been used for centuries as food and traditional medicine in Asia and Europe. This study evaluated the effects of a nutraceutical consisting of sea buckthorn oil as a functional supplement (Omegia™ sea buckthorn oil). Subjects were randomly divided into two groups and were given capsules containing or without sea buckthorn oil. Skin elasticity, color, collagen, pore, and redness were measured using skin assessment instruments. Blood samples were taken to assess serum antioxidant levels by using ELISA (enzyme-linked immunosorbent assay) kit. Additionally, a questionnaire survey was conducted to gather information on subjects' experiences in eye discomfort and vaginal dryness issues. After 12 weeks, skin parameters showed improvement, and participants reported relief from dry eyes and vulvar issues. This study highlights the potential of Omegia™ supplements demonstrating the ability to delay skin aging, increase high-density lipoprotein cholesterol, and antioxidant enzyme activity when used continuously for a period of 12 weeks.

An Assessment of the Effectiveness and Safety of ULTRACOL100 as a Device for Restoring Skin in the Nasolabial Fold Region

One of the most notable signs of an aging face is the nasolabial folds (NLFs), which often diminish emotional well-being and self-confidence. To address this concern, many people seek solutions to improve their appearance, often turning to fillers. The ULTRACOL100 device, a tissue restoration material, has been previously investigated and shown to exhibit significant efficacy in both in vitro and in vivo studies. In this research, we aim to explore the safety and effectiveness of the clinical trial of ULTRACOL100 in improving the skin in the NLF area over an 8-week observation period. Male and Female adults with nasolabial folds received two injections of ULTRACOL100, with a 4-week interval between treatments, on one side of their faces. On the other side, they received control materials (REJURAN®, JUVELOOK®, or HYRONT®). The assessment of skin improvement in the nasolabial fold area for each subject took place before and four weeks after each application. Various skin parameters, such as roughness, elasticity, moisture, transparency, trans-epidermal water loss, tone, radiance, skin pore size, and skin density, were measured to evaluate the outcomes. The application of the ULTRACOL100 device significantly reduced the skin roughness, the trans-epidermal water loss, and the skin pore size and increased the skin’s elasticity and internal elasticity, as well as the skin’s moisture, transparency, skin tone, radiance, and density. This study comprehensively investigates the effectiveness and safety of the ULTRACOL100 device, comparing it with three commercial products (REJURAN®, JUVELOOK®, and HYRONT®). The ULTRACOL100 device showed comparable performance in improving the appearance of the NLF area among this study subjects.

Correlating facial skin parameters with age and gender in population of Shaanxi Province, China.

This study was designed to comprehensively evaluate the changes in facial skin biophysical parameters with age, as well the influence of gender differences in populations of Shaanxi Province, China. Fourteen skin parameters, including stratum corneum hydration (SCH), transdermal water loss (TEWL), erythema, melanin, R0, R2, R5, R7, F4, gloss, skin surface pH, skin erythema index (a*), wrinkle length, and sebum, were measured by noninvasive instruments in 481 volunteers from Shaanxi Province. Spearman correlation analysis was performed to analyze the relationship between skin parameters and age. Additionally, skin parameters were analyzed for different age groups and different genders. The results of the study showed a linear decrease in skin surface pH and sebum content with age, and the skin elasticity parameters R0, R2, R5, and R7 decreased significantly at the age of 54-65 years. Wrinkle length showed a linear and increase with age. R5 showed a weak negative correlation with age, R2, R7, and sebum content showed a moderate negative correlation, while wrinkle length showed a strong positive correlation. Considering the effect of gender on skin parameters, the results showed that SCH and gloss were lower in men than in women, while TEWL, erythema, melanin, wrinkle length, and sebum were higher than in women. However, there was no difference in skin elasticity between them. The facial skin parameters, especially for the wrinkle length, exhibited the strong correlation relationship with ages in Shaanxi Province. Meanwhile, most skin parameters show significant differences with gender, which can provide a reference for future research and development in the field of cosmetics.

Experience of using benzoyl peroxide and clindamycin gel in the treatment of mild and moderate acne

BACKGROUND: Acne is an actual problem for both patients and doctors of different specialties, especially dermatovenerologists and cosmetologists. Up to 85% of young people are affected by the disease. Skin lesions on the face and lack of effect of previously administered therapy are often accompanied by severe psychosocial maladjustment even in mild forms of dermatosis. In addition, recently there has been a tendency towards increased resistance of Cutibacterium acnes to antibacterial agents, which requires the development of drugs, including those to prevent antibiotic resistance.&#x0D; AIM: Clinical and morphofunctional assessment of the effectiveness and tolerability of the Zerkalin Intensive gel (benzoyl peroxide and clindamycin) in patients with mild to moderate acne.&#x0D; MATERIALS AND METHODS: the study involved 30 patients with acne (28 women and 2 men) aged 18 to 34 years, 4 of them had mild severity, 26 had moderate severity. All patients applied benzoyl peroxide and clindamycin gel once a day in the evening, the observation period was 12 weeks. Dermatological examination was carried out visually with a simple count of inflammatory lesions (papules, pustules). In order to assess the morphofunctional parameters of facial skin, all patients underwent a non-invasive digital study using the Capricorn AI Intelligent Imager Bitmoji device, based on 3D visualization. To study the impact of the disease on various aspects of the patient's life and as an effectiveness criterion, the Dermatology life Quality Index (DLQI) was used.&#x0D; RESULTS: in all patients using the benzoyl peroxide and clindamycin gel there was a regression of inflammatory and non-inflammatory elements and a decrease in post-acne phenomenon, while an improvement in the condition of the skin process was registered within the first 2–4 weeks. As a result of the treatment, complete cleansing of the skin was achieved in 8 patients, significant improvement in 17, and improvement in 5. At the end of the entire observation period, according to the questionnaire, the subjects observed a decrease in DLQI compared with the baseline (18.4±3.03 versus 3.03±0.15; p 0.05), which indicates an improvement of the quality of life and psychoemotional state of patients and the effectiveness of therapy.&#x0D; CONCLUSION: Benzoyl peroxide and clindamycin gel for the treatment of mild to moderate acne is an effective remedy, especially with a predominance of pustular elements, which is confirmed based on the results of a visual examination and the positive dynamics of indicators of superficial and deep analysis of facial skin (sebumetry, corneometry, pigmentation, reactivity and level colonization by C. acnes). The gel was well tolerated by patients and did not cause any adverse events or allergic reactions.

The FEDBD plasma’s quantitative investigation of skin parameters: Skin elasticity, thickness, density, tissue oxygenation, perfusion, and edema

This study used the FEDBD plasma device for skin rejuvenation in animal samples. There were two groups of six male Wistar rats. Before starting the treatment, immediately after the treatment, the fourth week, and the tenth week of follow-up, biometric tests were performed, including moisture level, evaporation from the skin surface, erythema and melanin, skin elasticity and firmness with an MPA9 device and cutometer. The thickness and density of the epidermis and dermis, an essential indicator in rejuvenation, were evaluated with a skin ultrasound device. Also, the level of oxygen, perfusion, and interstitial water (edema) was checked using a Tivita tissue hyperspectral camera at a depth of 6 mm of the skin.

Squalene Peroxidation and Biophysical Parameters in Acne-Prone Skin: A Pilot "In Vivo" Study.

Nowadays, acne vulgaris therapies are often unsuccessful. One of the responsible factors for the formation of comedones and inflammatory lesions could be the peroxidation of squalene, a hydrocarbon representing one of the major components of human sebum. This peroxidation is increased by solar irradiation. The purpose of this work was to set up an in vivo method for the extraction and quantification of squalene from acne skin and to correlate the results with biophysical skin parameters such as sebum amount, protein content and TEWL. Healthy volunteers were used as control. The results obtained demonstrated that acne-prone skin had a major quantity of squalene, and, in the stratum corneum area, its peroxide form is present. Moreover, Spearman's rank correlation showed a positive correlation between sebum content and peroxide squalene and between porphyrin intensity and peroxide squalene.

Effect of Pulsing Digital Heating Devices on Skin Parameters, Subjective Pain, Mood, and Anxiety

A common pitfall of many conventional heat therapy methods is the propensity to lose heat over time and the need for reheating and reapplication. Pain-relieving digital heating devices are now available that can be held in place on the body via adhesive or magnet and provide pulsed heat. However, the safety of such devices among different ages and skin types must be established. We conducted a prospective, open-label study to assess the effect of three consecutive thirty-minute treatment cycles on skin parameters and pain. Effects on mood and anxiety were secondarily assessed. 22 adult participants (20 female, 2 male; mean 58 ± 17.63 years) were recruited. The participants attended one visit with heating device intervention and a follow-up visit after 7–10 days. A 97% significant increase in transepidermal water loss was observed immediately following intervention (p = 8.04487 × 10−7), although significance was not sustained at follow-up. There was an increase along the red/green axis at 13/14 treatment locations immediately following treatment, although only four locations remained significantly increased at follow-up. Pain non-significantly decreased immediately following treatment (p = 0.057). A 38.6% decrease in subjective anxiety was observed immediately after treatment (p = 0.0139), and scores remained non-significantly reduced at follow-up (19.3% reduction from baseline; p = 0.1397). The heating devices elicit temporary changes to the skin, although the lack of significance at follow-up suggests that the devices can be safely used without long-term changes in skin color or barrier status.

Nutritional, Productive, and Qualitative Characteristics of European Quails Fed with Diets Containing Lipid Sources of Plant and Animal Origin.

The objective of this study was to investigate the impact of alternative lipid sources on nutrient metabolism, performance, carcass characteristics, and meat quality in European quails. Trial 1 determined the energy values and nutrient metabolizability of non-conventional lipid sources. Six treatments (control, soybean oil, conventional corn oil, distilled corn oil, poultry fat, and beef tallow) were randomly assigned with 10 replicates per treatment. Trial 2 evaluated animal performance, carcass characteristics, and meat quality using a randomized design with five treatments and 10 replicates each. Statistical analysis showed no significant difference in apparent metabolizable energy corrected by nitrogen (AMEn) and coefficients of metabolizability (CM%) among the lipid sources. The AMEn values found were 8554 for soybean oil, 7701 for corn, 7937 for distilled corn oil, 7906 for poultry fat, and 7776 for beef tallow (kcal/kg). The CM values were 88.01% for soybean oil, 79.01% for corn oil, 84.10% for distilled corn oil, 81.43% for poultry fat, and 79.28% for beef tallow. The inclusion of lipid sources of plant and animal origin in the diet of 7-35-day old meat quails did not influence performance or carcass and cut characteristics. The inclusion of distilled corn oil increased carcass yield and influenced skin and meat color parameters. AMEn values varied for each lipid source. The inclusion of distilled corn oil positively influenced skin and meat color as well as carcass yield in quails.

Minolexin® in complex therapy of papulo-pustular acne of moderate severity (results of own research)

The aim of the study. A retrospective analysis of the results of complex therapy of moderate papulo-pustular acne with minocycline 50 mg per day orally and 15 % azelaic acid gel topically under natural ultraviolet irradiation.Materials and methods. In a retrospective study, data from outpatient charts and the results of studying the morpho-functional parameters of the facial skin of 61 people (31 acne patients and 30 healthy individuals) were analyzed. Patients received oral minocycline (Minolexin®) 50 mg per day for 6 weeks and topically 15 % azelaic acid gel 2 times a day for 12 weeks in the period from April to September.Results and discussion. The therapy was effective: clinical cure occurred in 90.3 % (n = 28), clinical remission – in 9.7 % (n = 3) patients. Rapid regression of papulo-pustules was achieved through the use of minocycline, which had antibacterial and anti-inflammatory effects. After treatment, elevated values of sebumetry, skin relief, pore size, and pigmentation were normalized in the group of patients with acne, due to the action of a topical gel, as well as the absence of photosensitizing effect in minocycline. Systemic and local adverse events registered in outpatient records were of a temporary nature and did not require discontinuation of therapy.

Comprehensive assessment of the efficacy and safety of a clay mask in oily and acne skin.

Oily skin, characterized by excessive sebum production, can lead to acne and have psychosocial impacts due to changes in appearance. Recent research has shown interest in treatments for oil control, with kaolin and bentonite emerging as promising options. Despite their potential, comprehensive studies on these ingredients are still in the nascent stages. This study aimed to assess the efficacy of a clay mask (La Roche-Posay Effaclar Sebo-Controlling Mask) in reducing skin oiliness and acne, and its safety for use. In this study, 75 adults with oily or combination skin were enrolled and provided with a clay mask for twice-weekly use over 4 weeks. Clinical assessments, using instruments like Sebumeter, Vapometer, and Corneometer, were conducted at baseline, and after 1, 2, and 4weeks, evaluating acne lesions, skin irritation, sebum content, and skin hydration. Participant self-assessment questionnaires were also utilized for subjective evaluation. Statistical analyses were performed accordingly. The study revealed significant improvements in acne-related outcomes, sebum content, skin evenness, stratum corneum water content, and transepidermal water loss following the application of the clay mask. Pore area and porphyrin area showed no significant changes. Tolerance assessment showed reduced dryness and irritation, with self-assessment indicating high product acceptability and perceived oil control effectiveness. This study demonstrated the clay mask's efficacy in managing acne and oily skin, improving hydration and texture. Significant improvements in skin parameters and high product safety were observed, supporting its suitability.