The paper analyzes the problem of defining the potential of geothermal reservoirs and the definition of a sustainable size of a geothermal power plant in the preliminary design phase. While defining the size of a geothermal plant, the objective is to find a compromise between renewability, technical sustainability, and economic return-related issues. In the first part of the paper the simplified lumped parameter approach based on the First-Order methods and their further evolutions and limitations is proposed. Experimental data available for some geothermal reservoirs are used for critical analysis of the simplified approaches for estimating the renewability and sustainability of the production of geothermal plants. In the second part the authors analyze methods based on theoretical heat transfer analysis supported by experimental data acquired from the geothermal field (thermal properties of the rock, porosity of the reservoir, and natural heat flux) and finally consider the numerical simulation as a method to connect the two approaches discussed before. The sustainability of geothermal power production can be estimated taking into account the energy stored in the reservoir and the thermal and fluid dynamic analysis of the reservoir. From this perspective, the numerical simulation of the reservoir can be considered as an effective method for the estimation of a sustainable mass flow rate extraction. Some specific cases are analyzed and discussed.