This paper focuses on the optimum design of the e-CLT technology. The e-CLT technology consists in adding cross laminated timber (CLT) walls to an existing reinforced concrete (RC) infilled frame via asymmetric friction connection (AFC). The authors carried out quasi-static and nonlinear dynamic analyses. The RC frame is modeled in OpenSees by fiber-section-based elements with force-based formulation. The contribution of the infill is simulated using a degrading data-driven Bouc–Wen model with a slip-lock element while the AFC is modelled with a modified Coulomb model. Different types of infill, aspect ratio, scaling, and member size are considered. The benefits of using e-CLT technology are discussed and the ranges of optimum performance of the AFC are estimated. A comparison of the performance of traditional infills with the e-CLT system is presented. The authors provide optimum intervals of the ratio between slip force and in-plane stiffness of the CLT panel, following energy and displacement-based criteria. The seismic displacement demand under various seismic scenario is investigated. Correlations between the RC characteristics and the optimum design ratios bestow possible criteria for the design of the AFC.