This study aims to examine experimentally and numerically the thermal-hydraulic performance and entropy generation of wavy channels: sinusoidal and triangular, and compare them with respect to the straight channel. Various wavy amplitudes and corrugation profiles are considered in a sinusoidal wavy channel and a triangular wavy channel and assessed with the straight channel. Experimental test rig is built and the experiments are carried out on laminar air flow and used to verify the simulation results. The main findings show that the HT rate, fluid flow, and entropy generation are affected by the corrugation profile and wave amplitude of the wavy channel. The maximum Nusselt number of 11.17 occurred in a sinusoidal wavy channel with a wave amplitude equal to 1.75, and high friction factor also happens in this model. It was found that the sinusoidal and triangular wavy channels with A = 0.75 and a flow rate range of 1–1.75 have the highest overall thermal performance factor. Also, the total entropy generation of the straight channel was lower than all corrugated channel models. In conclusion, it has been found that the best compromise between enhanced HT and the accompanying increase in both pressure drop and entropy generation is occurred in case of A = 0.75 at flow rate ranged from 1 to 1.67 LPM.