Single Model Research Articles

Integration of B-to-B trade network models of structural evolution and monetary flows reproducing all major empirical laws

We develop a single two-layered model framework that captures and replicates both the statistical properties of the network as well as those of the intrinsic quantities of the agents. Our model framework consists of two distinct yet connected elements that were previously only studied in isolation, namely methods related to temporal network structures and those associated with money transport flows. Within this context, the network structure emerges from the first layer and its topological structure is transferred to the second layer associated with the money transactions. In this manner, we can explain how the micro-level dynamics of the agents within the network lead to the exogenous manifestation of the aggregated system statistical data en-wrapping the very same agents within the system. This is done by capturing the essential dynamics of collective motion in complex networks that enable the simultaneous emergence of tent-shaped distributions in growth rates within the agents, together with the emergence of scaling properties within the network in the study. We can validate the model framework and dynamics by applying these to the context of the real-world inter-firm trading network of firms in Japan and comparing the results of the statistical distributions at both network and agent levels in a temporal manner. In particular, we compare our results to the fundamental quantities supporting the seven empirical laws observed in data: the degree distribution, the mean degree growth rate over time, the age distribution of the firms, the preferential attachment, the sales distribution in steady states, their growth rates, their scaling relations generated by the model. We find these results to be nearly identical to the real-world data. The framework has the potential to be transformed into a forecasting tool to support decision-makers on financial and prudential policies.

Towards a Reliable Design of Geopolymer Concrete for Green Landscapes: A Comparative Study of Tree-Based and Regression-Based Models

The design of geopolymer concrete must meet more stringent requirements for the landscape, so understanding and designing geopolymer concrete with a higher compressive strength challenging. In the performance prediction of geopolymer concrete compressive strength, machine learning models have the advantage of being more accurate and faster. However, only a single machine learning model is usually used at present, there are few applications of ensemble learning models, and model optimization processes is lacking. Therefore, this paper proposes to use the Firefly Algorithm (AF) as an optimization tool to perform hyperparameter tuning on Logistic Regression (LR), Multiple Logistic Regression (MLR), decision tree (DT), and Random Forest (RF) models. At the same time, the reliability and efficiency of four integrated learning models were analyzed. The model was used to analyze the influencing factors of geopolymer concrete and determine the strength of their influencing ability. According to the experimental data, the RF-AF model had the lowest RMSE value. The RMSE value of the training set and test set were 4.0364 and 8.7202, respectively. The R value of the training set and test set were 0.9774 and 0.8915, respectively. Therefore, compared with the other three models, RF-AF has a stronger generalization ability and higher prediction accuracy. In addition, the molar concentration of NaOH was the most important influencing factors, and its influence was far greater than the other possible factors including NaOH content. Therefore, it is necessary to pay more attention to NaOH molarity when designing geopolymer concrete.

Ante- and Post-Mortem Fracture Identification Protocol Based on Low- and High-Level Fusion Using Fourier Transform Infrared Spectroscopy and Raman Spectroscopy Association.

In this study, the application of low-level fusion (LLF) and high-level fusion (HLF) strategies using a combination of Fourier transform infrared spectroscopy (FT-IR) and Raman spectroscopy in the identification of antemortem and postmortem fracture at different postmortem intervals (PMIs) was investigated. On a technical level, the same hard tissue sample can be detected using a mix of FT-IR and Raman techniques. At the method level, two cutting-edge chemometrics approaches (LLF and HLF) combining FT-IR and Raman spectroscopic data are explored. The models were ranked in accordance with their parametric quality as follows: HLF and LLF + HLF models > LLF single model > Raman single model > FT-IR single model. The LLF model performed marginally better than the Raman model, however, when compared to other models, the HLF model performed considerably better. The HLF model achieved the best performance, with both cross-validation accuracy and test data set accuracy of 0.88. The importance of the feature wavelengths in the model construction process was subsequently evaluated by intersection fusion, and it was found that the absorbance bands of amide I, PO43- ν1 ν3, and CH2 in FT-IR and phenylalanine, CO32- ν1- PO43- ν3, and amide III in Raman have outstanding contributions to the construction of antemortem and postmortem fractures identification models. Overall, the combination of FT-IR and Raman with the HLF strategy is a novel and promising approach for developing antemortem and postmortem fracture identification models at different PMIs.

The DMF: Fault Diagnosis of Diaphragm Pumps Based on Deep Learning and Multi-Source Information Fusion

Effective fault diagnosis for diaphragm pumps is crucial. This paper proposes a diaphragm pump fault diagnosis method based on deep learning and multi-source information fusion (DMF). The time-domain features, frequency-domain features, and modulation features are extracted from the vibration signals from eight different positions. After feature enhancement and data preprocessing, the features are input into auto encoders (AE), convolutional neural networks (CNN), and support vector machines (SVM) to obtain the diagnostic results. The results indicate that the DMF method achieves a fault diagnosis accuracy of 99.98%, which is on average 9.09% higher than using a single diagnostic model. The demodulation method is more suitable for vibration signal feature extraction of the diaphragm pump, while the CNN is more suitable for identification of diaphragm pump faults. Specifically, it outperformed the sampling point 1-DPCA-AE model by 13.98% and the sampling point 4-DPCA-SVM model by 8.98%.

Categorization of the effects of E. coli LF82 and mutants lacking the chuT and shuU genes on survival, the transcriptome, and metabolome in germ-free honeybee.

The precise etiology of inflammatory bowel diseases (IBDs) remains elusive. The Escherichia coli strain LF82 (LF82) is known to be associated with IBD, and we hypothesized that this association may be related to the chuT and shuU genes. Here we constructed a germ-free (GF) honeybee model to investigate the effects of LF82 chuT and shuU genes on the honeybee intestine and their mechanisms. The chuT and shuU gene deletion strains LF82∆chuT and LF82∆shuU were generated by CRISPR-Cas9. These strains, together with nonpathogenic E. coli MG1655 (MG1655) and wildtype LF82, were allowed to colonize the guts of GF honeybees to establish single bacterial colonization models. Intestinal permeability was assessed following the administration of a sterile Brilliant Blue (FCF) solution. Comprehensive transcriptomic and metabolomic analyses of intestinal samples indicated that MG1655 had few disadvantageous effects on honeybees. Conversely, colonization with LF82 and its gene-deletion mutants provoked pronounced activation of genes associated with innate immune pathways, stimulated defensive responses, and induced expression of genes associated with inflammation, oxidative stress, and glycosaminoglycan degradation. Crucially, the LF82∆chuT and LF82∆shuU strains perturbed host heme and iron regulation, as well as tryptophan metabolism. These findings suggest that the deletion of chuT and shuU genes in E. coli LF82 may alleviate intestinal inflammation by partially modulating tryptophan catabolism. Our study proposes that targeting iron uptake mechanisms could be a potential strategy to mitigate the virulence of IBD-associated bacteria.

Scaling from global to regional river flow with global hydrological models: Choice matters

High-resolution global flow discharge datasets are critical to understand the terrestrial water cycle and river ecosystem services. Recently, a number of global hydrological models have been developed to capture global river flow dynamics at locally relevant scales. However, the relative accuracy of these simulated flow discharges is largely unknown. In this paper, using the largest observed streamflow datasets from > 26,000 gauging stations, we evaluated the performance of monthly and sub-monthly flow variation (1980–2014) generated from five major global hydrological models, Catchment-based Macro-scale Floodplain model (CaMa-Flood), Global Flood Awareness System (GloFAS-reanalysis), Global Reach-level Flood Reanalysis (GRFR), PCRaster GLOBal Water Balance model (PCR-GLOBWB), and Water Global Assessment and Prognosis (WaterGAP). Significant spatial heterogeneity in model performance was identified. We found that estimates by all five discharge datasets have a relatively high correlation with the observations (medians > 0.6). But none of them showed adequate correlations between simulated and observed flows for systems in Southwest or Central U.S.A., South Africa, or South Australia. Across all models, overestimation of monthly mean flow was more common than underestimation and high flows at a sub-monthly scale were more accurately characterized than low flows. Performance of all models was poor in Africa and Oceania. No single model performed universally best at all gauging stations, but GRFR showed the best estimate at around 40 % of the locations. None of the models provided satisfying estimates for rivers and streams in arid regions. We also found a significant negative effect of flow regulation on the predictive accuracy of all models. Our study highlights the importance of thorough evaluation of global discharge datasets before their local and regional application and provides guidance for future enhancement of global hydrological models.

Subgroup identification-based model selection to improve the predictive performance of individualized dosing.

Currently, model-informed precision dosing uses one population pharmacokinetic model that best fits the target population. We aimed to develop a subgroup identification-based model selection approach to improve the predictive performance of individualized dosing, using vancomycin in neonates/infants as a test case. Data from neonates/infants with at least one vancomycin concentration was randomly divided into training and test dataset. Population predictions from published vancomycin population pharmacokinetic models were calculated. The single best-performing model based on various performance metrics, including median absolute percentage error (APE) and percentage of predictions within 20% (P20) or 60% (P60) of measurement, were determined. Clustering based on median APEs or clinical and demographic characteristics and model selection by genetic algorithm was used to group neonates/infants according to their best-performing model. Subsequently, classification trees to predict the best-performing model using clinical and demographic characteristics were developed. A total of 208 vancomycin treatment episodes in training and 88 in test dataset was included. Of 30 identified models from the literature, the single best-performing model for training dataset had P20 26.2-42.6% in test dataset. The best-performing clustering approach based on median APEs or clinical and demographic characteristics and model selection by genetic algorithm had P20 44.1-45.5% in test dataset, whereas P60 was comparable. Our proof-of-concept study shows that the prediction of the best-performing model for each patient according to the proposed model selection approaches has the potential to improve the predictive performance of model-informed precision dosing compared with the single best-performing model approach.

Deep Multimodal Data Fusion

Multimodal Artificial Intelligence (Multimodal AI), in general, involves various types of data (e.g., images, texts, or data collected from different sensors), feature engineering (e.g., extraction, combination/fusion), and decision-making (e.g., majority vote). As architectures become more and more sophisticated, multimodal neural networks can integrate feature extraction, feature fusion, and decision-making processes into one single model. The boundaries between those processes are increasingly blurred. The conventional multimodal data fusion taxonomy (e.g., early/late fusion), based on which the fusion occurs in, is no longer suitable for the modern deep learning era. Therefore, based on the main-stream techniques used, we propose a new fine-grained taxonomy grouping the state-of-the-art (SOTA) models into five classes: Encoder-Decoder methods, Attention Mechanism methods, Graph Neural Network methods, Generative Neural Network methods, and other Constraint-based methods. Most existing surveys on multimodal data fusion are only focused on one specific task with a combination of two specific modalities. Unlike those, this survey covers a broader combination of modalities, including Vision + Language (e.g., videos, texts), Vision + Sensors (e.g., images, LiDAR), etc., and their corresponding tasks (e.g., video captioning, object detection). Moreover, a comparison among these methods is provided, as well as challenges and future directions in this area.

Efficiency of Identification of Blackcurrant Powders Using Classifier Ensembles.

In the modern times of technological development, it is important to select adequate methods to support various food and industrial problems, including innovative techniques with the help of artificial intelligence (AI). Effective analysis and the speed of algorithm implementation are key points in assessing the quality of food products. Non-invasive solutions are being sought to achieve high accuracy in the classification and evaluation of various food products. This paper presents various machine learning algorithm architectures to evaluate the efficiency of identifying blackcurrant powders (i.e., blackcurrant concentrate with a density of 67 °Brix and a color coefficient of 2.352 (E520/E420) in combination with the selected carrier) based on information encoded in microscopic images acquired via scanning electron microscopy (SEM). Recognition of blackcurrant powders was performed using texture feature extraction from images aided by the gray-level co-occurrence matrix (GLCM). It was evaluated for quality using individual single classifiers and a metaclassifier based on metrics such as accuracy, precision, recall, and F1-score. The research showed that the metaclassifier, as well as a single random forest (RF) classifier most effectively identified blackcurrant powders based on image texture features. This indicates that ensembles of classifiers in machine learning is an alternative approach to demonstrate better performance than the existing traditional solutions with single neural models. In the future, such solutions could be an important tool to support the assessment of the quality of food products in real time. Moreover, ensembles of classifiers can be used for faster analysis to determine the selection of an adequate machine learning algorithm for a given problem.

Design of Computer Information Management System Based on Machine Learning Algorithms

In order to improve the efficiency of office automation, regulate work frequency, and improve office efficiency, this paper presents a computer information management system design based on machine learning technology. Firstly, the basic design principles of computer information management systems are analyzed, and secondly, risk prediction is studied. The risk of computer information management systems is caused by the cross influence of different risk factor indicators, and has linear and nonlinear characteristics. Using a single prediction model cannot obtain accurate prediction results. Therefore, the risk prediction method for computer information management based on machine learning technology. The risk prediction method is established by using Analytic Hierarchy Method in machine learning algorithms, and the historical data is collected according to the index system. The weight of the initial prediction is determined by the combination of subjective and objective weight; In machine learning algorithms, risk prediction and benefit prediction are used as input and output methods for cloud machine learning. Through training and training, a risk prediction model is established to obtain higher prediction efficiency. The simulation results show that the prediction accuracy of this method is 95.5%, which can estimate the hazard existing in computer information management and improve the method.

A minimal physiologically based pharmacokinetic model to study the combined effect of antibody size, charge, and binding affinity to FcRn/antigen on antibody pharmacokinetics.

Protein therapeutics have revolutionized the treatment of a wide range of diseases. While they have distinct physicochemical characteristics that influence their absorption, distribution, metabolism, and excretion (ADME) properties, the relationship between the physicochemical properties and PK is still largely unknown. In this work we present a minimal physiologically-based pharmacokinetic (mPBPK) model that incorporates a multivariate quantitative relation between a therapeutic's physicochemical parameters and its corresponding ADME properties. The model's compound-specific input includes molecular weight, molecular size (Stoke's radius), molecular charge, binding affinity to FcRn, and specific antigen affinity. Through derived and fitted empirical relationships, the model demonstrates the effect of these compound-specific properties on antibody disposition in both plasma and peripheral tissues using observed PK data in mice and humans. The mPBPK model applies the two-pore hypothesis to predict size-based clearance and exposure of full-length antibodies (150kDa) and antibody fragments (50-100kDa) within a onefold error. We quantitatively relate antibody charge and PK parameters like uptake rate, non-specific binding affinity, and volume of distribution to capture the relatively faster clearance of positively charged mAb as compared to negatively charged mAb. The model predicts the terminal plasma clearance of slightly positively and negatively charged antibody in humans within a onefold error. The mPBPK model presented in this work can be used to predict the target-mediated disposition of a drug when compound-specific and target-specific properties are known. To our knowledge, a combined effect of antibody weight, size, charge, FcRn, and antigen has not been incorporated and studied in a single mPBPK model previously. By conclusively incorporating and relating a multitude of protein's physicochemical properties to observed PK, our mPBPK model aims to contribute as a platform approach in the early stages of drug development where many of these properties can be optimized to improve a molecule's PK and ultimately its efficacy.

A multi-task fusion model based on a residual–Multi-layer perceptron network for mammographic breast cancer screening

Background and objectiveDeep learning approaches are being increasingly applied for medical computer-aided diagnosis (CAD). However, these methods generally target only specific image-processing tasks, such as lesion segmentation or benign state prediction. For the breast cancer screening task, single feature extraction models are generally used, which directly extract only those potential features from the input mammogram that are relevant to the target task. This can lead to the neglect of other important morphological features of the lesion as well as other auxiliary information from the internal breast tissue. To obtain more comprehensive and objective diagnostic results, in this study, we developed a multi-task fusion model that combines multiple specific tasks for CAD of mammograms. MethodsWe first trained a set of separate, task-specific models, including a density classification model, a mass segmentation model, and a lesion benignity–malignancy classification model, and then developed a multi-task fusion model that incorporates all of the mammographic features from these different tasks to yield comprehensive and refined prediction results for breast cancer diagnosis. ResultsThe experimental results showed that our proposed multi-task fusion model outperformed other related state-of-the-art models in both breast cancer screening tasks in the publicly available datasets CBIS-DDSM and INbreast, achieving a competitive screening performance with area-under-the-curve scores of 0.92 and 0.95, respectively. ConclusionsOur model not only allows an overall assessment of lesion types in mammography but also provides intermediate results related to radiological features and potential cancer risk factors, indicating its potential to offer comprehensive workflow support to radiologists.

Deep Learning for Plant Identification and Disease Classification from Leaf Images: Multi-prediction Approaches

Deep learning (DL) plays an important role in modern agriculture, especially in plant pathology using leaf images where convolutional neural networks (CNN) are attracting a lot of attention. While numerous reviews have explored the applications of DL within this research domain, there remains a notable absence of an empirical study to offer insightful comparisons due to the employment of varied datasets in the evaluation. Furthermore, a majority of these approaches tend to address the problem as a singular prediction task, overlooking the multifaceted nature of predicting various aspects of plant species and disease types. Lastly, there is an evident need for a more profound consideration of the semantic relationships that underlie plant species and disease types. In this article, we start our study by surveying current DL approaches for plant identification and disease classification. We categorise the approaches into multi-model, multi-label, multi-output, and multi-task, in which different backbone CNNs can be employed. Furthermore, based on the survey of existing approaches in plant pathology and the study of available approaches in machine learning, we propose a new model named Generalised Stacking Multi-output CNN (GSMo-CNN). To investigate the effectiveness of different backbone CNNs and learning approaches, we conduct an intensive experiment on three benchmark datasets Plant Village, Plant Leaves, and PlantDoc. The experimental results demonstrate that InceptionV3 can be a good choice for a backbone CNN as its performance is better than AlexNet, VGG16, ResNet101, EfficientNet, MobileNet, and a custom CNN developed by us. Interestingly, there is empirical evidence to support the hypothesis that using a single model for both tasks can be comparable or better than using two models, one for each task. Finally, we show that the proposed GSMo-CNN achieves state-of-the-art performance on three benchmark datasets.

Development of single point prediction model using artificial neural network and experimental validation for pump as turbine applications

This paper proposed a new approach based on artificial neural networks (ANNs) to select the most appropriate centrifugal pumps for reverse operation i.e. pump as turbines (PAT), by predicting parameters at Best Efficiency Point from pump mode data. Both, exhaustive experimental data of 49 pumps (specific speeds 9−104) collected from open literature and by in-house experimentation data, considered input data-set as pump and target data-set as PAT are used for training the ANN models with two different training functions: Levenberg–Marquardt and Bayesian regularisation. The proposed ANN prediction model shows a deviation lower than 10% compared to the respective experimental value. Additionally, the trained ANN model tested with four pumps (not included in training data sets of proposed models) shows maximum absolute deviation in head number, flow number, and efficiency within the 10%, 7%, and 6% range, respectively, compared to the experimental values. Furthermore, the efficiency of reverse mode evaluated for variation in rotational speed shows a maximum of 3.3% (within 5%) absolute deviation compared to respective experimental results. Overall, the ANNs based prediction model of PAT parameters is recommended compared to conventional models available in the literature as it gives superior results (less than 10% deviation) for practical application.

Regional choroidal thickness estimation from color fundus images based on convolutional neural networks

PurposeThis study aims to estimate the regional choroidal thickness from color fundus images from convolutional neural networks in different network structures and task learning models. Method1276 color fundus photos and their corresponding choroidal thickness values from healthy subjects were obtained from the Topcon DRI Triton optical coherence tomography machine. Initially, ten commonly used convolutional neural networks were deployed to identify the most accurate model, which was subsequently selected for further training. This selected model was then employed in combination with single-, multiple-, and auxiliary-task training models to predict the average and sub-region choroidal thickness in both ETDRS (Early Treatment Diabetic Retinopathy Study) grids and 100-grid subregions. The values of mean absolute error and coefficient of determination (R2) were involved to evaluate the models' performance. ResultsEfficientnet-b0 network outperformed other networks with the lowest mean absolute error value (25.61 μm) and highest R2 (0.7817) in average choroidal thickness. Incorporating diopter spherical, anterior chamber depth, and lens thickness as auxiliary tasks improved predicted accuracy (p-value = 6.39×10−44, 2.72×10−38, 1.15×10−36 respectively). For ETDRS regional choroidal thickness estimation, multi-task model achieved better results than single task model (lowest mean absolute error = 31.10 μm vs. 33.20 μm). The multi-task training also can simultaneously predict the choroidal thickness of 100 grids with a minimum mean absolute error of 33.86 μm. ConclusionsEfficientnet-b0, in combination with multi-task and auxiliary task models, achieve high accuracy in estimating average and regional macular choroidal thickness directly from color fundus photographs.

BapFL : You can Backdoor Personalized Federated Learning

In federated learning (FL), malicious clients could manipulate the predictions of the trained model through backdoor attacks, posing a significant threat to the security of FL systems. Existing research primarily focuses on backdoor attacks and defenses within the generic federated learning scenario, where all clients collaborate to train a single global model. A recent study conducted by Qin et al. [24] marks the initial exploration of backdoor attacks within the personalized federated learning (pFL) scenario, where each client constructs a personalized model based on its local data. Notably, the study demonstrates that pFL methods with parameter decoupling can significantly enhance robustness against backdoor attacks. However, in this paper, we whistleblow that pFL methods with parameter decoupling are still vulnerable to backdoor attacks. The resistance of pFL methods with parameter decoupling is attributed to the heterogeneous classifiers between malicious clients and benign counterparts. We analyze two direct causes of the heterogeneous classifiers: (1) data heterogeneity inherently exists among clients and (2) poisoning by malicious clients further exacerbates the data heterogeneity. To address these issues, we propose a two-pronged attack method, BapFL , which comprises two simple yet effective strategies: (1) poisoning only the feature encoder while keeping the classifier fixed and (2) diversifying the classifier through noise introduction to simulate that of the benign clients. Extensive experiments on three benchmark datasets under varying conditions demonstrate the effectiveness of our proposed attack. Additionally, we evaluate the effectiveness of six widely used defense methods and find that BapFL  still poses a significant threat even in the presence of the best defense, Multi-Krum. We hope to inspire further research on attack and defense strategies in pFL scenarios. The code is available at: https://github.com/BapFL/code.

A Personalized Federated Learning Method Based on Clustering and Knowledge Distillation

Federated learning (FL) is a distributed machine learning paradigm under privacy preservation. However, data heterogeneity among clients leads to the shared global model obtained after training, which cannot fit the distribution of each client’s dataset, and the performance of the model degrades. To address this problem, we proposed a personalized federated learning method based on clustering and knowledge distillation, called pFedCK. In this algorithm, each client has an interactive model that participates in global training and a personalized model that is only trained locally. Both of the models perform knowledge distillation with each other through the feature representation of the middle layer and the soft prediction of the model. In addition, in order to make an interaction model only obtaining the model information from the client, which has similar data distribution and avoids the interference of other heterogeneous information, the server will cluster the clients according to the similarity of the amount of parameter variation uploaded by different interaction models during every training round. By clustering clients, interaction models with similar data distributions can cooperate with each other to better fit the local dataset distribution. Thereby, the performance of personalized model can be improved by obtaining more valuable information indirectly. Finally, we conduct simulation experiments on three benchmark datasets under different data heterogeneity scenarios. Compared to the single model algorithms, the accuracy of pFedCK improved by an average of 23.4% and 23.8% over FedAvg and FedProx, respectively; compared to typical personalization algorithms, the accuracy of pFedCK improved by an average of 0.8% and 1.3%, and a maximum of 1.0% and 2.9% over FedDistill and FML.

Catalytic effects on peristaltic flow of Jeffrey fluid through a flexible porous duct under oblique magnetic field: Application in biomimetic pumps for hazardous materials

Homogenous and heterogeneous reactions play an essential role in polymer production, combustion, ceramic production, catalysis, distillation, and biochemical procedures. As a result of this advancement, a mathematical model is developed to examine the role of catalytic chemical reaction effects on the magneto-hydrodynamic peristaltic transport in a flexible divergent duct containing a non-deformable porous medium as a model for complex hazardous waste bio-inspired pumping mechanisms. The Jeffrey model is utilized to simulate strong non-Newtonian characteristics. Additional multi-physical features included in the model are heat generation, thermal radiation, Hall current, and complaint wall properties along with an inclined (oblique) magnetic field. The long wavelength and low Reynolds number approximations are deployed to transform the primitive conservation equations from a moving boundary problem to a fixed frame. Appropriate transformations are then utilized to render the model dimensionless. The exact solutions are obtained for stream function and velocity. Further, the R-K-Fehlberg integration scheme is applied to solve the energy and concentration equations. Velocity, temperature, concentration, skin friction, and Nusselt number profiles are visualized graphically. Streamline patterns are also included to capture bolus dynamics. Validation with previous simpler studies has been included. A detailed appraisal of key control parameters on transport characteristics is conducted. It is found that velocity is suppressed with elevation in the damping force parameter while it is enhanced with an increment in regime permeability i. e. Darcy number. Both homogeneous and heterogeneous reactions are observed to exert a significant impact on the species concentration. The volume of the trapped fluid bolus size is shown to be an increasing function of the peristaltic wave amplitude ratio. The present work generalizes existing studies to consider catalytic effects on dissipative peristaltic pumping of the Jeffrey fluid with heat generation and radiative flux, aspects which have been neglected in a single model previously. The simulations are relevant to better characterize the complex transport phenomena in nuclear reactor waste transport via biologically inspired pumping designs.

Gaussian Process Emulation for High-Dimensional Coupled Systems

Complex coupled multiphysics simulations are ubiquitous in science and engineering. Evaluating these numerical simulators is often costly which limits our ability to run them sufficiently often for forward uncertainty quantification. Furthermore outputs are generally not scalar quantities but depend on space and/or time. Gaussian process emulators are statistical surrogates which can approximate the output of the complex computer models at untested inputs quickly while also providing uncertainty information about the accuracy of evaluating the emulator rather than the full physical model. GP emulators were originally developed in the context of scalar output from a single physical model but have since been extended to vector-valued quantities of interest (parallel partial emulators) and to coupled physics by connecting two independent emulators, one for each type of physics (linked emulation). The parallel partial linked GP emulator (PPLE) developed in this work combines the efficiency of a shared correlation structure with the accuracy of linked emulators to produce a new tool for emulating compositions of functions with vector-valued output. The PPLE applied to two numerical experiments out-performs direct emulation of the output composite function producing results with smaller average prediction error and variance. The authors report there are no competing interests to declare.

High-resolution EEG source localization in personalized segmentation-free head model with multi-dipole fitting

Objective. Electroencephalograms (EEGs) are often used to monitor brain activity. Several source localization methods have been proposed to estimate the location of brain activity corresponding to EEG readings. However, only a few studies evaluated source localization accuracy from measured EEG using personalized head models in a millimeter resolution. In this study, based on a volume conductor analysis of a high-resolution personalized human head model constructed from magnetic resonance images, a finite difference method was used to solve the forward problem and to reconstruct the field distribution. Approach. We used a personalized segmentation-free head model developed using machine learning techniques, in which the abrupt change of electrical conductivity occurred at the tissue interface is suppressed. Using this model, a smooth field distribution was obtained to address the forward problem. Next, multi-dipole fitting was conducted using EEG measurements for each subject (N = 10 male subjects, age: 22.5 ± 0.5), and the source location and electric field distribution were estimated. Main results. For measured somatosensory evoked potential for electrostimulation to the wrist, a multi-dipole model with lead field matrix computed with the volume conductor model was found to be superior than a single dipole model when using personalized segmentation-free models (6/10). The correlation coefficient between measured and estimated scalp potentials was 0.89 for segmentation-free head models and 0.71 for conventional segmented models. The proposed method is straightforward model development and comparable localization difference of the maximum electric field from the target wrist reported using fMR (i.e. 16.4 ± 5.2 mm) in previous study. For comparison, DUNEuro based on sLORETA was (EEG: 17.0 ± 4.0 mm). In addition, somatosensory evoked magnetic fields obtained by Magnetoencephalography was 25.3 ± 8.5 mm using three-layer sphere and sLORETA. Significance. For measured EEG signals, our procedures using personalized head models demonstrated that effective localization of the somatosensory cortex, which is located in a non-shallower cortex region. This method may be potentially applied for imaging brain activity located in other non-shallow regions.