Single-mode Research Articles

US/PA/MR multimodal imaging-guided multifunctional genetically engineered bio-targeted synergistic agent for tumor therapy

Focused ultrasound ablation surgery (FUAS) is a minimally invasive treatment option that has been utilized in various tumors. However, its clinical advancement has been hindered by issues such as low safety and efficiency, single image guidance mode, and postoperative tumor residue. To address these limitations, this study aimed to develop a novel multi-functional gas-producing engineering bacteria biological targeting cooperative system. Pulse-focused ultrasound (PFUS) could adjust the ratio of thermal effect to non-thermal effect by adjusting the duty cycle, and improve the safety and effectiveness of treatment.The genetic modification of Escherichia coli (E.coli) involved the insertion of an acoustic reporter gene to encode gas vesicles (GVs), resulting in gas-producing E.coli (GVs-E.coli) capable of targeting tumor anoxia. GVs-E.coli colonized and proliferated within the tumor while the GVs facilitated ultrasound imaging and cooperative PFUS. Additionally, multifunctional cationic polyethyleneimine (PEI)-poly (lactic-co-glycolic acid) (PLGA) nanoparticles (PEI-PLGA/EPI/PFH@Fe3O4) containing superparamagnetic iron oxide (SPIO, Fe3O4), perfluorohexane (PFH), and epirubicin (EPI) were developed. These nanoparticles offered synergistic PFUS, supplementary chemotherapy, and multimodal imaging capabilities.GVs-E.coli effectively directed the PEI-PLGA/EPI/PFH@Fe3O4 to accumulate within the tumor target area by means of electrostatic adsorption, resulting in a synergistic therapeutic impact on tumor eradication.In conclusion, GVs-E.coli-mediated multi-functional nanoparticles can synergize with PFUS and chemotherapy to effectively treat tumors, overcoming the limitations of current FUAS therapy and improving safety and efficacy. This approach presents a promising new strategy for tumor therapy.Graphical

Micro-welding of non-optical contact sapphire/metal using Burst femtosecond laser

Recently, welding of dissimilar material, such as transparent material to metal material, is widely used in aerospace, microelectronic packaging, medicine, etc. Ultrafast laser welding provides a new method for high-performance dissimilar material welding, in which the non-optical contact dissimilar material welding has become a new research hot spot. In this paper, we report the effective welding of Fe-36Ni with roughness as high as 1.1 µm to sapphire, which, to our knowledge, is the roughest dissimilar material welding achieved in ultrafast laser. A 238 fs, 1035 nm, 200 kHz Burst mode femtosecond laser (4 sub-pulses with a total energy of 132.5μJ) yields a smooth and uniform interface with a welding strength up to 11 MPa. In this context, the welding performance and mechanism of Burst mode and single pulse mode ultrafast laser are systematically analyzed. The relevant research results are expected to provide theoretical guidance for the welding of high-strength and high-stability dissimilar materials.

Transverse magnetic supermodes in plasmonic optical fibers excited by radially polarized light

The overlap integrals method, with a fully vectorial formulation, is used to model the selective excitation of the TM01 mode in a few-mode optical fiber with a radially polarized donut beam, and its coupling to guided modes having a plasmonic character (supermodes). The analyses were performed on a waveguide formed as a step-index few-mode optical fiber coated with a thin gold film, at an operating wavelength of 1310 nm. The waveguide was found to support modes having optical fiber, circular metallic waveguide, and surface plasmon characteristics, depending on geometrical and material parameters. Three purely bound transverse magnetic (radially polarized) supermodes were identified: Two symmetric, labeled sTM01 and sTM02 modes, and one asymmetric, labeled ab mode, where symmetry pertains to the transverse electric field distribution over the gold film. The effective mode indices of the supermodes were studied as a function of the thickness of the gold film and its proximity to the fiber core. Considerations for the selective excitation of the sTM01 mode are discussed along with its possible applications. The transmittance of the supermodes is found to be robust even at sharp waveguide transitions. The results predict that effective excitation of TM supermodes with strong plasmonic character, without significant coupling losses, can be achieved by exciting the fiber with a radially polarized donut beam.

Orbital angular momentum superimposed mode recognition based on multi-label image classification

Orbital angular momentum (OAM) multiplexing technology has great potential in high capacity optical communication. OAM superimposed mode can extend communication channels and thus enhance the capacity, and accurate recognition of multi-OAM superimposed mode at the receiver is very crucial. However, traditional methods are inefficient and complex for the recognition task. Machine learning and deep learning can offer fast, accurate and adaptable recognition, but they also face challenges. At present, the OAM mode recognition mainly focus on single OAM mode and ±l superimposed dual-OAM mode, while few researches on multi-OAM superimposed mode, due to the limitations of single-object image classification techniques and the diversity of features to recognize. To this end, we develop a recognition method combined with multi-label image classification to accurately recognize multi-OAM superimposed mode vortex beams. Firstly, we create datasets of intensity distribution map of three-OAM and four-OAM superimposed mode vortex beams based on numerical simulations and experimental acqusitions. Then we design a progressive channel-spatial attention (PCSA) model, which incorporates a progressive training strategy and two weighted attention modules. For the numerical simulation datasets, our model achieves the highest average recognition accuracy of 94.9% and 91.2% for three-OAM and four-OAM superimposed mode vortex beams with different transmission distances and noise strengths respectively. The highest experimental average recognition accuracy for three-OAM superimposed mode achieves 92.7%, which agrees with the numerical result very well. Furthermore, our model significantly outperforms in most metrics compared with ConvNeXt, and all experiments are within the affordable range of computational cost.

One molecule to couple them all: Toward realistic numbers of molecules in multiscale molecular dynamics simulations of exciton-polaritons.

Collective strong coupling of many molecules to the confined light modes of an optical resonator can influence the photochemistry of these molecules, but the origin of this effect is not yet fully understood. To provide atomistic insights, several approaches have been developed based on quantum chemistry or molecular dynamics methods. However, most of these methods rely on coupling a few molecules (or sometimes only one) to a single cavity mode. To reach the strong coupling regime with such a small number of molecules, much larger vacuum field strengths are employed than in experiments. To keep the vacuum field realistic and avoid potential artefacts, the number of coupled molecules should be significantly increased instead, but that is not always possible due to restrictions on computational hardware and software. To overcome this barrier and model the dynamics of an arbitrarily large ensemble of molecules coupled to realistic cavity fields in atomistic molecular dynamics simulations, we propose to coarse-grain subsets of molecules into one or more effective supermolecules with an enhanced dipole moment and concerted dynamics. To verify the validity of the proposed multiscale model, we performed simulations in which we investigated how the number of molecules that are coupled to the cavity affects excited-state intra-molecular proton transfer, polariton relaxation, and exciton transport.

Planar waveguide to vertical mode couplers covering the visible to IR spectral range

Planar 45o turning mirrors with metal coating embedded in SU8 polymer waveguides enable waveguide to vertical mode coupling across a broad range of wavelengths from the visible to IR. The fabrication of these 2.5D structures is achieved using relatively simple grayscale lithography in thin film resists, compatible with standard planar lithography methods. Mirror losses of <1 dB are measured from 516 -1630 nm, and direct coupling to single mode fibre is achieved.

Implementation of Optical Coherent Communication System between Two Computers

This work represents implementation and investigation of optical coherent communication system between two computers. A single mode optical fiber is selected as transmission medium. The data are sent via the RS-232 standard interface with a bit rate of 9.6 kbps from personal computer (PC1) by line receive to convert the data from electrical levels (-12/+12 V) into TTL level (0/5 V). The modulation of this data was accomplished by internal modulation using laser diode type (HFCT-5208M) 1310 nm wavelength. The optical D-coupler was used to combine the optical signal that come from laser source with optical signal of laser local oscillator (OTS-304XI) at 1310/1550 nm wavelength to obtain coherent (homodyne and heterodyne) detection respectively. A PIN photodetector (HFCT-5208M) is used. Calculations of Signal to Noise Ratio (SNR) and Bit Error Rate (BER) for coherent detection were measured at different length of the optical fiber. Result show that high SNR and low BER for heterodyne detection than for homodyne detection.

Three‐Pronged Induction of Tumor Calcification Synergistic Calcium Immunotherapy Enables Diagnosis and Cure of Cancer

AbstractTumor calcification is considered to have the superiority of integrating tumor diagnosis and treatment, and it also has been found to be a predictor of favorable prognosis. However, selecting suitable nanocarriers and therapeutic drugs to maximize the tumor calcification efficiency are key factors for improving calcification‐medicated theranostics. This study performs a multi‐channel calcification nanoinitiator (CalNI, i.e., BP‐Cur‐Ca@PKLAK) by loading curcumin (Cur) and depositing Ca2+ on black phosphorus (BP) and combined carrying mitochondria‐targeting cytotoxic peptide KLAK to boost a triple‐induced tumor calcification. CalNI preferentially accumulates inside tumor mitochondria and induces multilevel calcification promotion by the three combined effects of (i) the degradation of BP into PO43− provides the phosphorus source required for calcification; (ii) burst of calcium ions can directly induce cellular calcium overload; (iii) Cur can inhibit calcium efflux thus further aggravate intracellular calcium stress. Moreover, KLAK exhibited enhanced mitochondrial synergistic toxic effects. Notably, the potential function of CalNI on the regulation of macrophage polarization could completely reverse the immunosuppressive microenvironment, and activate the initiation of T cell‐mediated immune response. Therefore, this three‐pronged CalNI showed a huge promise to be an alternative to conventional oncology therapy, which presents a more satisfactory therapeutic efficiency than any kind of single induction mode.

High-sensitivity humidity sensor based on Mach-Zehnder interferometer in seven-core fiber

A Mach-Zehnder Interferometer (MZI) based on seven-core fiber (SCF) for humidity sensing is proposed and experimentally demonstrated. The MZI is formed by sandwiched a section of SCF in between two single mode fibers (SMFs), while a fiber taper and a brief multimode fiber (MMF) act as fiber couplers to excite and couple the intermodal interference in the SCF. The optical field distribution and coupling efficiency of the MZI with different SCF lengths are analysed. The theoretical results show that the MZI is sensitive to SCF lengths, and it is expected to obtain highly sensitive humidity response. Humidity sensing experiments shows a high sensitivity of 0.6603 nm/%RH over a relative humidity (RH) range of 44–83 %RH, and the maximum measurement uncertainty introduced by the long-term stability is 0.0006 %RH. Human respiration measurement exhibits the response time and recovery time of the MZI are 0.44 s and 1.24 s respectively. The temperature effect is also experimentally investigated. Such an all-fiber MZI presents advantages of simple configuration, high sensitivity and good stability, making it has potential in humidity measurement fields.

Dynamic analysis of whipping behavior induced by the circumferential fracture of high energy pipes considering fluid-structure interaction effect

To analyze the dynamic characteristics of whipping behavior induced by the circumferential fracture of high energy pipes, a numerical model of the piping system was presented based on the bidirectional fluid-structure interaction method. The reliability of this model was validated against experimental results. Furthermore, the dynamic characteristics of whipping behavior were studied, as well as the effects of some main parameters. The numerical results suggest that the entire whipping behavior can be divided into four stages: free-whipping stage Ⅰ, free-whipping stage Ⅱ, collision stage and periodic stage. The dynamic response of whipping behavior is different in the four stages and is dominated by a single mode with a frequency of 29.35 Hz under the combined action of the thrust force and U-bolt restraints. The increase of inlet flow rate causes the enhancement of thrust force and thus makes its dynamic response more complicated. The parameter analysis shows that the whipping behavior can be suppressed by choosing the small initial clearance, setting the suitable gap and increasing the straight segment length of U-bolt restraints. The above results are helpful to understand the dynamic characteristics of whipping behavior and provide valuable suggestions for the optimization of the protection measures.

Quantum tomography with τ leptons at the FCC-ee: Entanglement, Bell inequality violation, sinθW , and anomalous couplings

The Future Circular Collider (FCC)—in its first incarnation as a lepton collider—will produce, according to the proposed design, more than 100 billion pairs of τ leptons after working for four years at the energy of the Z-boson resonance. The τ lepton is special because its relatively long lifetime makes it possible to reconstruct the momenta of neutrinos emitted in the single pion decay mode. The resulting large number of events is an ideal source for a full quantum tomography of the process that will test quantum entanglement and the violation of Bell inequality with unprecedented precision. In addition, the study of polarizations and spin correlations can provide a competitive determination of the Weinberg angle θW and constrain possible anomalous couplings in the neutral electroweak current. We utilize analytic results and Monte Carlo simulations to explore to what extent these goals might be accomplished. Published by the American Physical Society 2024

A 6-mode pre-amplifier for turbulence-resistant free-space optical communication

A few-mode pre-amplifier with high gain and high coupling efficiency was suitable for the turbulence-resistant free-space optical (FSO) communication. Here, we first built and experimentally demonstrated a forward- and core-pumped 6-mode (6 M) pre-amplifier. By optimizing the 6 M erbium-doped fiber (EDF) length, we achieved over 28 dB of gain and a noise figure of less than 7 dB with an input intensity of −30 dBm. Moreover, we experimentally evaluated the 6 M pre-amplifier of 2.5 Gbps On-Off Keying (OOK) signal transmission with a homemade tunable turbulence emulator. The advantages of the 6 M pre-amplifier over the single-mode (SM) pre-amplifier varied with channel turbulence conditions in terms of communication performances. Compared with the SM pre-amplifier, the coupling efficiencies increased by 4.5 dB and 5.8 dB on average, and the median bit error rates (BERs) of the communication system improved by 2 and 5 orders of magnitude, respectively, in the presence of channels with the scintillation index σI2 of 0.3978 and 1.0553 (moderate to strong turbulence).

High-harmonic generation by a bright squeezed vacuum

AbstractHigh-harmonic generation has been driving the development of attosecond science and sources. More recently, high-harmonic generation in solids has been adopted by other communities as a method to study material properties. However, so far high-harmonic generation has only been driven by classical light, despite theoretical proposals to do so with quantum states of light. Here we observe non-perturbative high-harmonic generation in solids driven by a macroscopic quantum state of light, a bright squeezed vacuum, which we generate in a single spatiotemporal mode. The process driven by a bright squeezed vacuum is considerably more efficient in the generation of high harmonics than classical light of the same mean intensity. Due to its broad photon-number distribution, covering states from 0 to 2 × 1013 photons per pulse, and strong subcycle electric field fluctuations, a bright squeezed vacuum gives access to free carrier dynamics within a much broader range of peak intensities than accessible with classical light.

Programmable multi-wavelength distributed feedback laser array integrated in a liquid crystal polymer waveguide.

Liquid crystal (LC) distributed feedback (DFB) lasers hold significant potential for integrated photonics applications. However, limitations in wavelength spacing for wavelength switching, device size, and compatibility with other technologies have impeded advancements of the LC DFB laser in integration and responsiveness. Herein, we propose a thin-film multi-wavelength DFB laser array utilizing high-resolution patterned programmable nematic LC polymers, enabling rapid switching with high-resolution wavelength spacing between wavelength division multiplexing channels while maintaining a stable single longitudinal mode (SLM) for each laser. The underlying physical mechanism involves modulating the effective refractive index of the DFB laser by varying the LC molecules' orientation angles between adjacent regions of the LC grating to achieve wavelength modulation. Additionally, a specialized LC waveguide design connects the DFB lasers, facilitating wavelength modulation as well as straight-line and bending propagation of the laser. Furthermore, the laser array demonstrates a relatively low energy threshold, facilitating its applications in high-integration scenarios.

Monolithic top emitting room temperature THz DFG QCL with index grating for wavelength selection

We present a high performance top emitting room temperature monolithic terahertz (THz) quantum cascade laser based on difference frequency generation (DFG) and a buried modulated distributed feedback grating. Using a semi-insulating InP:Fe substrate combined with an index-coupled grating could minimize the internal losses for the THz mode. The laser consists of two separate transversely superimposed gratings. The first grating provides selective feedback for the mid-infrared pump modes and is realized in an index-coupled DFG grating designed for single-mode operation for two distinct MIR wavelengths. The second metallic grating for THz extraction is carefully aligned to the spatial distribution of the MIR modes. The resulting device lases pulses up to 150 °C in the single mode. The maximum THz output power at RT is 100 μW measured at 3.37 THz. A THz wavelength tuning of around 0.065 nm/K was achieved through thermal tuning of the MIR pump lasers.

Polarization-maintaining fiber based macehead shaped interferometric sensor for accurate measurement of refractive index and temperature

A macehead-shaped bent polarization-maintaining fiber-based interferometric sensing structure called MBPIS is described and experimentally demonstrated for precise temperature and refractive index measurement. The sensor’s working principle is explained by simulating the spatial distribution of the field intensity in straight and bending PANDA fibers. A maximum extinction ratio (∼21 dBm) for the interference dip wavelength (1527.825 nm) in the sensor’s output spectrum was optimized by manipulating the birefringence of propagating fiber modes by adjusting PMF’s bending diameter from 17 to 11 mm. The phase difference changes between these fiber modes due to temperature and RI-induced birefringence cause a shift in the interference spectrum. The sensor’s highest RI sensitivity has been seen at −259.32 nm/RIU for a wide range of analytes from 1.3333 to 1.3579. In contrast, the highest temperature sensitivities evaluated for the temperature range of 0 ∼ 100 ℃ are −220 pm/℃ and −0.139 dBm/℃, respectively.

Single-fundamental-mode cryogenic (3.6 K) 850-nm oxide-confined VCSEL

Cryogenic oxide-confined vertical-cavity surface-emitting laser (VCSEL) has promising application in cryogenic optical interconnect for cryogenic computing. In this paper, we demonstrate a cryogenic 850-nm oxide-confined VCSEL at around 4 K. The cryogenic VCSEL with an optical oxide aperture of 6.5 μm in diameter can operate in single fundamental mode with a side-mode suppression-ratio of 36 dB at 3.6 K, and the fiber-coupled output power reaches 1 mW at 5 mA. The small signal modulation measurements at 298 and 292 K show the fabricated VCSEL has the potential to achieve a high modulation bandwidth at cryogenic temperature.

A compact solid-state high repetition rate trigger based on a spiral generator.

The trigger generator made with a spiral generator (SG) has the advantages of light weight, compact structure, and low cost and has promising applications in the pulsed power field. This paper introduces a compact solid-state high-voltage pulse trigger system based on an improved SG, which has improved repetition rate and lowered the demands for semiconductor switches' maximum current and current rise rate when compared with previous studies. The improvement is achieved by winding outward an additional layer of the passive layer and low-voltage metal strip, which realizes a significant reduction of the peak current and current rise rate of the discharge switch. The final dimension of the trigger is 25 × 10 × 10cm3, excluding the power supply. An experiment carried out in single shot mode shows that the peak value of the output pulse can reach 50kV with a leading edge of 57ns. Repetitive experiments were carried out up to 1kHz, with the peak voltage of the output pulse being 30.5kV, the leading edge being 48ns, and the jitter being 0.84ns. Finally, the generator is used to trigger a gas switch, and it works stably and reliably.

Dual Modal Face Recognition Based on Visible Light and Thermal Infrared

Abstract In recent years, face recognition has received widespread attention, in the use of visible light for face recognition, there are a series of problems that require auxiliary light sources, may be attacked by photos, and camouflage is difficult to penetrate. Compared with visible light recognition, thermal infrared face recognition shows usability, and it can still be stable in low light or dark extreme environmental conditions, but due to low resolution, it can not capture rich face feature information. In view of this paper proposes that dual mode face recognition can effectively integrate two single mode information and make up for the deficiency of single feature. Using a Bimodal Face network model based on visible light and thermal infrared, the idea of feature decoupling is introduced into image fusion. The cross-modal information is decomposed into common information and unique information, and the common information and unique information of different modes are fused respectively according to the feature fusion method. It is tested on the self-built dual modal dataset that this fusion strategy can achieve the optimal effect, and the accuracy rate can reach 97.08%, which is better than other five face recognition network models.

Influence of the core shape on the quality of fiber sensors based on D-shape fiber

Typical optical sensors based on D-shape fibers use standard step-index single-mode fibers (SMF) with a circular core. Multi-mode fibers, fibers with elliptical or rectangular cores, and photonic crystal fibers (PCF) are also used to achieve the best possible sensor performance. However, since the presented sensors differ not only in geometry but, most importantly, in the materials and core sizes, it is difficult to compare their properties directly. In this paper, we numerically analyzed the influence of the shape and size of the core on the sensing performance, with all other relevant parameters being equal. Full Text: PDF References D. Jauregui-Vazquez, J. P. Korterik, C. E. Osornio-Martinez, J. M. Estudillo-Ayala, H. L. Offerhaus, J. A. Alvarez-Chavez, "A strain reflection-based fiber optic sensor using thin core and standard single-mode fibers", Opt. Comm. 522, 128659 (2022). CrossRef H. H. Liu, D. J. Hu, Q. Z. Sun, L. Wei, K. W. Li, C. Liao, B. Li, C. Zhao, X. Dong, Y. Tang, Y. Xiao, G. Keiser, P. Shum, "Specialty optical fibers for advanced sensing applications", Opto-Electron Sci. 2(2), 220025 (2023). CrossRef K. Gasior, T. Martynkien, P. Mergo, W. Urbanczyk, "Fiber-optic surface plasmon resonance sensor based on spectral phase shift interferometric measurements", Sensors and Actuators B: Chemical 257, 602 (2018). CrossRef Y. Ying, G. Si, F. Luan, K. Xu, Y. Qi, H. Li, "Recent research progress of optical fiber sensors based on D-shaped structure", Opt. & Laser Techn. 90, 149 (2017). CrossRef J. Homola, Surface Plasmon Resonance Based Sensors (Berlin, Springer 2006). CrossRef K. Gasior, T. Martynkien., M. Napiorkowski, K. Zolnacz, P. Mergo, W. Urbanczyk, "A surface plasmon resonance sensor based on a single mode D-shape polymer optical fiber", J. Opt. 19, 025001 (2017). CrossRef Q. Wang, W. M. Zhao, "A comprehensive review of lossy mode resonance-based fiber optic sensors", Opt. Lasers in Engineering 100, 47 (2018). CrossRef K. Gasior, T. Martynkien, G. Wojcik, P. Mergo, W. Urbanczyk, "D-shape polymer optical fibres for surface plasmon resonance sensing", Opto-Electron. Rev. 24(4), 209 (2016). CrossRef G. Stepniewski, A. Filipkowski, D. Pysz, J. Warszewski, R. Buczynski, M. Smietana, R. Kasztelanic, "From D-shaped to D-shape optical fiber – A universal solution for sensing and biosensing applications: Drawn D-shape fiber and its sensing applications", Measurement 222, 113642 (2023). CrossRef R. Kasztelanic, H. T. Nguyen, D. Pysz, H. Thienpont, T. Omatsu, R. Buczynski, "Free-Form Optical Fiber with a Square Mode and Top-HatIntensity Distribution", Adv. Science 11, 2402886 (2024). CrossRef J.W. Fleming, "Dispersion in GeO2-SiO2 glasses", Appl. Opt. 23, 4486-4493 (1984). CrossRef T.A. König, P.A. Ledin, J. Kerszulis, M.A. Mahmoud, M.A. El-Sayed, J.R. Reynolds, V.V. Tsukruk., "Electrically Tunable Plasmonic Behavior of Nanocube–Polymer Nanomaterials Induced by a Redox-Active Electrochromic Polymer", ACS Nano 8, 6182-6192 (2014). CrossRef I.Z. Kozma, P. Krok, E. Riedle, "Direct measurement of the group-velocity mismatch and derivation of the refractive-index dispersion for a variety of solvents in the ultraviolet", J. Opt. Soc. Am. B 22, 1479-1485 (2005). CrossRef