Single Image Feature Research Articles

New methods for chromosome analysis were applied to the study of testicular tumours, seminomas, malignant teratomas and combined tumours (seminoma + malignant teratoma) in order to compare the abnormalities observed in these tumours. The profile method, which was intended to summarize all the karyotypes of a tumour in a single composite image, showed consistent and divergent features between the tumours. Seminomas had a characteristic profile which reflected an excess of F-group chromosomes and a lack of Nos. 17–18. The tumours were classified by ther profiles, but it was not possible in this way clearly to distinguish the three histological types. The proportional method, in which were evaluated the ratios between the complements of the chromosome groups taken in pairs, showed that certain deviations from the normal were consistent throughout a histological type (seminomas-proportions of B/C, B/F, 17–18/F, decreased and C/17–18 increased; malignant teratomas—B/16, B/F B/G, D/F decreased and 3/B, C/D increased; combined tumours—B/C, B/F 17–18/F decreased and 3/B increased). It seems noteworthy that the deviations recorded for the combined tumours were common to either or both of the other two types.

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