Evaluation method of slotted screen performance is a critical concern for sand control. Despite its significance, comprehensive investigations into quantitative study of sand retaining during the complex flow process need further in-depth study, particularly in numerical simulation research model of the slotted screen. This paper adopts the two-way coupling calculation method of computational fluid dynamics (CFD) and discrete element method (DEM) for the particle movement and fluid flow at the slotted screen and establishes a numerical model of the sand particle migration process through the slotted screen. The sand particle deposition and plugging dynamics on the surface of the sand retaining medium and the micro sand plugging mechanism and blockage pattern are studied. The fractal dimension of formation sand is introduced to characterize different distribution of formation sand. The effects of fluid viscosity, width of the slotted screen, sand production concentration, fluid velocity and particle size distribution on sand production, sand passing rate and particle size distribution of formation sand passing through the slot and plugging behavior are studied. The sand plugging process of slotted screen can be divided into three stages: the beginning of blockage, the intensification of blockage, and the balance of blockage. Under simulated conditions, the initial sand plugging rate is 87%, and as the blockage intensifies, the sand plugging rate gradually increases to 96.5%. Based on the analysis of numerical simulation results, the index of total seepage resistance damage amplitude and velocity, general sand retention ratio and passed-sand size were defined to construct the integrated evaluation method of slotted screen media, which involves the performance of sand retention, anti-plugging and flow ability. A brand new set of ideas on quantifying the integrated evaluation method were introduced to calculate the individual and integrated performance indicators of the slotted screen based on simulated data. The quantitative evaluation of the sand control performance of the slotted screen provides guidance and reference for the parameter design of the slotted screen in the target oil region and the accuracy optimization of the sand control medium.