A new reactive separation process concept termed solid-phase reactive separation system (SPRSS) is proposed which integrates the progressing batch reactor (PBR) and simulated moving bed (SMB) chromatography processes. The key idea of this new process is that both PBR and SMB employ similar principles of the movement of the liquid feed to imitate the countercurrent movement of solid and liquid phases. This concept may be applied to the reactive separation system that involves solid reactants. In this work, SPRSS is applied to the production of sugar from cellulosic materials which contain different amounts of cellulose and hemicellulose in which the kinetics of each hydrolysis reaction path are different. SPRSS enables the variation of these reaction parameters within the reactor system to hydrolyze different portions of the biomass, which allows more flexible acid catalyst concentration profiles. The overarching goal is to improve the total sugar yield and concentration while minimizing the sugar decomposition reaction and undesired product formation. An optimization strategy using a superstructure formulation is applied to find the optimal process design of SPRSS using a continuous moving-bed model. The optimal results show a potential improvement of the sugar yield as well as less byproduct formation by changing the acid concentration using the SPRSS configuration design. The effect of different kinetic parameters is investigated, which could significantly affect the performance of SPRSS. Several observations of the values of these kinetic parameters which could further enhance the advantages of SPRSS design are demonstrated.